Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:antidote to opioid poisoning
go back to main search page
Accession:CHEBI:90755 term browser browse the term
Definition:A role borne by a molecule that acts to counteract or neutralise the deleterious effects of opioids.
Synonyms:related_synonym: antidote to opioid overdose
 xref: PMID:24510187;   PMID:24868924


show annotations for term's descendants           Sort by:
 
naloxone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
EXP Naloxone results in increased expression of ABCB1 mRNA
[Morphine co-treated with Naloxone] results in increased expression of ABCB1A mRNA
CTD PMID:17522070, PMID:26554626 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Naloxone results in increased expression of ABCC3 mRNA CTD PMID:17522070 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions EXP [Morphine co-treated with Naloxone] results in increased expression of ABCG2 mRNA CTD PMID:26554626 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acly ATP citrate lyase decreases expression EXP Naloxone results in decreased expression of ACLY mRNA CTD PMID:17522070 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Naloxone inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein] CTD PMID:17989109 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of AKT1 protein modified form] CTD PMID:20600172 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression EXP Naloxone results in decreased expression of APEX1 mRNA CTD PMID:17522070 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Avp arginine vasopressin decreases secretion ISO Naloxone results in decreased secretion of AVP protein CTD PMID:6850280 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]] CTD PMID:12927789 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO
EXP
Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]
Naloxone results in increased expression of BCL2 protein
CTD PMID:12927789, PMID:16004788 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Calca calcitonin-related polypeptide alpha affects activity
multiple interactions
EXP Naloxone affects the activity of CALCA protein
Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]]; Naloxone inhibits the reaction [Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]]
CTD PMID:7906887, PMID:10075105, PMID:27030709 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of CASP3 protein alternative form] CTD PMID:20600172 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase increases expression EXP Naloxone results in increased expression of CAT mRNA CTD PMID:17522070 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cck cholecystokinin multiple interactions EXP Naloxone inhibits the reaction [CCK protein results in decreased activity of Apomorphine] CTD PMID:3561887 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Naloxone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:17084265 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in decreased expression of CCL5 protein] CTD PMID:11106302 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
affects binding
ISO CES1 protein binds to and results in increased metabolism of Naloxone
Naloxone binds to CES1 protein
CTD PMID:12679808, PMID:12773168 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Crh corticotropin releasing hormone decreases expression EXP Naloxone results in decreased expression of CRH mRNA CTD PMID:12431775 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 multiple interactions
increases response to substance
EXP
ISO
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased secretion of POMC protein modified form]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Naloxone
CRHR1 gene mutant form results in increased susceptibility to Naloxone
CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
CTD PMID:24398105, PMID:25582704, PMID:28434951 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Ctsl cathepsin L increases expression EXP Naloxone results in increased expression of CTSL mRNA CTD PMID:17522070 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Ddb2 damage specific DNA binding protein 2 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of DDB2] CTD PMID:19397953 NCBI chr 3:80,030,437...80,052,984
Ensembl chr 3:80,030,437...80,052,953
JBrowse link
G Drd4 dopamine receptor D4 multiple interactions ISO [3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 protein] inhibits the reaction [Naloxone results in increased abundance of Cyclic AMP] CTD PMID:15542745 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO Naloxone inhibits the reaction [Oxycodone results in increased phosphorylation of EIF2S1 protein] CTD PMID:26377394 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Fasn fatty acid synthase decreases expression EXP Naloxone results in decreased expression of FASN mRNA CTD PMID:17522070 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in decreased secretion of FGF2 protein] CTD PMID:20564181 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
[Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]
1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea inhibits the reaction [[Morphine co-treated with Naloxone] results in increased expression of FOS protein]; [Morphine co-treated with Naloxone] results in increased expression of FOS protein; [Naloxone co-treated with Morphine] results in increased expression of FOS protein; Pentobarbital promotes the reaction [Naloxone results in increased expression of FOS protein]; SL 327 inhibits the reaction [Naloxone results in increased expression of FOS protein]
CTD PMID:9041360, PMID:15196794, PMID:16935424, PMID:17549049, PMID:22590628, PMID:25308750 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Naloxone results in increased expression of GADD45A mRNA CTD PMID:17522070 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of GSK3B protein modified form] CTD PMID:20600172 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Naloxone results in decreased expression of GSTM3 mRNA CTD PMID:17522070 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions EXP Naloxone inhibits the reaction [Morphine results in increased expression of HSPA1A mRNA] CTD PMID:15497504 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Naloxone results in increased expression of HSPA5 protein CTD PMID:26377394 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Naloxone inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form] CTD PMID:10070497 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Naloxone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]] CTD PMID:12182845 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta increases response to substance ISO Naloxone results in increased susceptibility to IL1B protein CTD PMID:19458216 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions
decreases response to substance
ISO Freund's Adjuvant inhibits the reaction [Naloxone results in decreased susceptibility to IL2 protein] CTD PMID:12421473 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Naloxone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:17084265 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Klf7 Kruppel like factor 7 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of KLF7 mRNA] CTD PMID:14644156 NCBI chr 9:70,740,480...70,787,913
Ensembl chr 9:70,740,480...70,787,913
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Naloxone results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464
JBrowse link
G Lgals3 galectin 3 increases expression EXP Naloxone results in increased expression of LGALS3 mRNA CTD PMID:17522070 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression
affects expression
multiple interactions
ISO
EXP
Naloxone results in increased expression of LHB protein
Naloxone affects the expression of LHB protein
Naloxone affects the expression of and affects the secretion of LHB protein
CTD PMID:1794335, PMID:2745936, PMID:2880862, PMID:7629406, PMID:15905218 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lipc lipase C, hepatic type decreases expression EXP Naloxone results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G LOC100909485 spindlin-2-like decreases expression EXP Naloxone results in decreased expression of SPIN2B mRNA CTD PMID:17522070 NCBI chr  X:18,340,413...18,342,492
Ensembl chr  X:18,340,688...18,341,467
JBrowse link
G Ltf lactotransferrin decreases activity EXP Naloxone results in decreased activity of LTF protein CTD PMID:14563657 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
Naloxone results in increased phosphorylation of and results in increased activity of MAPK1 protein
Naloxone results in increased phosphorylation of MAPK1 protein
Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:17549049, PMID:21483469, PMID:24398105 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
Naloxone results in increased phosphorylation of and results in increased activity of MAPK3 protein
Naloxone results in increased phosphorylation of MAPK3 protein
Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:17549049, PMID:21483469, PMID:24398105 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mir16 microRNA 16 increases expression EXP Naloxone results in increased expression of MIR16 mRNA CTD PMID:17522070 NCBI chr 2:165,606,072...165,606,166
Ensembl chr 2:165,606,072...165,606,166
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions EXP Naloxone inhibits the reaction [Morphine results in increased activity of MME protein] CTD PMID:10070497 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]; [Morphine co-treated with Naloxone] results in increased activity of MMP9 protein CTD PMID:20519536 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mug1 murinoglobulin 1 decreases expression EXP Naloxone results in decreased expression of MUG1 mRNA CTD PMID:17522070 NCBI chr 4:154,676,382...154,729,288
Ensembl chr 4:154,391,647...154,729,310
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Naloxone results in increased expression of MYC mRNA CTD PMID:17522070 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein] CTD PMID:20519536 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Naloxone results in decreased expression of NPPA protein CTD PMID:11311734 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Naloxone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Naloxone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
ISO
EXP
[[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]]
Naloxone inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]
Naloxone binds to OPRM1 protein
[Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine; [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to N(6)-cyclopentyladenosine; Cannabidiol promotes the reaction [Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]]; Dronabinol promotes the reaction [Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]]; Naloxone binds to and results in decreased activity of OPRM1 protein; Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]
CTD PMID:1528399, PMID:1654493, PMID:7562497, PMID:8383026, PMID:8987795, PMID:9162281, PMID:11413242, PMID:16489449, PMID:21957251, PMID:23608241, PMID:27192616 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Otc ornithine carbamoyltransferase decreases expression EXP Naloxone results in decreased expression of OTC mRNA CTD PMID:17522070 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069
JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP Naloxone results in decreased expression of PKLR mRNA CTD PMID:17522070 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion
increases expression
ISO
EXP
[Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone; Naloxone binds to and results in increased activity of POMC protein alternative form
Naloxone results in increased secretion of POMC protein modified form
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased secretion of POMC protein modified form]; [Morphine co-treated with Naloxone] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Capsaicin inhibits the reaction [[Morphine co-treated with Naloxone] results in increased secretion of POMC protein]
Naloxone results in increased expression of POMC protein alternative form
CTD PMID:2255747, PMID:2846107, PMID:3157294, PMID:6089027, PMID:24398105 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Prl prolactin affects expression
decreases expression
ISO
EXP
Naloxone affects the expression of PRL protein
Naloxone results in decreased expression of PRL protein
CTD PMID:1794335, PMID:7629406 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ptma prothymosin alpha decreases expression EXP Naloxone results in decreased expression of PTMA mRNA CTD PMID:17522070 NCBI chr 9:93,545,396...93,549,436
Ensembl chr 9:93,545,396...93,549,436
JBrowse link
G Ren renin increases activity ISO Naloxone results in increased activity of REN protein CTD PMID:3157294 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Sell selectin L multiple interactions EXP Naloxone inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form] CTD PMID:10070497 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]] CTD PMID:11723065 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Naloxone inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Naloxone inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of SMPD1 protein] CTD PMID:22825003 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP Naloxone results in decreased expression of SREBF1 mRNA CTD PMID:17522070 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Naloxone inhibits the reaction [Morphine results in increased expression of TAC1 protein] CTD PMID:11976266 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases phosphorylation
EXP
ISO
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein]; [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein
[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein; CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
CTD PMID:24398105, PMID:25308750, PMID:25582704 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Naloxone results in decreased expression of THRSP mRNA CTD PMID:17522070 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Naloxone results in increased expression of TIMP1 mRNA CTD PMID:17522070 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Naloxone affects the reaction [Methadone binds to TLR4 protein]; Naloxone affects the reaction [Morphine binds to TLR4 protein] CTD PMID:20178837 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Naloxone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Naloxone results in decreased expression of TNF protein
CTD PMID:16004788, PMID:17084265 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression EXP Naloxone results in decreased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases expression
ISO
EXP
Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]]; Naloxone inhibits the reaction [Morphine results in increased expression of TP53]; Naloxone inhibits the reaction [Morphine results in increased phosphorylation of TP53 protein]
Naloxone results in decreased expression of TP53 mRNA
CTD PMID:12927789, PMID:17522070, PMID:19397953 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txn1 thioredoxin 1 increases expression EXP Naloxone results in increased expression of TXN mRNA CTD PMID:17522070 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 affects metabolic processing
increases glucuronidation
ISO UGT2B7 protein affects the metabolism of Naloxone
UGT2B7 protein results in increased glucuronidation of Naloxone
CTD PMID:15286053, PMID:28762043 NCBI chr14:22,597,103...22,619,968 JBrowse link
naltrexone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased cleavage of ATF6 protein] CTD PMID:27323860 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases secretion
EXP Naltrexone affects the reaction [Dynorphins results in decreased secretion of CRH protein]; Naltrexone inhibits the reaction [beta-Endorphin results in decreased secretion of CRH protein]
Naltrexone results in increased secretion of CRH protein
CTD PMID:3031743 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]; Naltrexone inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein] CTD PMID:27323860 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Drd2 dopamine receptor D2 affects response to substance ISO DRD2 affects the susceptibility to Naltrexone CTD PMID:19523047 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO Naltrexone promotes the reaction [Ethanol results in increased expression of EGR1 mRNA]
Naltrexone results in increased expression of EGR1 mRNA
CTD PMID:18427989 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2AK3 protein] CTD PMID:27323860 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased phosphorylation of ERN1 protein] CTD PMID:27323860 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases secretion
increases expression
ISO Naltrexone results in increased secretion of FSHB protein
Naltrexone results in increased expression of FSHB protein
CTD PMID:6323369, PMID:7745028 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 affects response to substance ISO GABRA6 affects the susceptibility to Naltrexone CTD PMID:19523047 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 affects response to substance ISO GABRB2 affects the susceptibility to Naltrexone CTD PMID:19523047 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased expression of HSPA5 mRNA] CTD PMID:27323860 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression
increases secretion
ISO Naltrexone results in increased expression of LHB protein
Naltrexone results in increased secretion of LHB protein
CTD PMID:6323369, PMID:7745028 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Nos2 nitric oxide synthase 2 decreases activity ISO Naltrexone results in decreased activity of NOS2 protein CTD PMID:15694688 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ogfr opioid growth factor receptor increases expression ISO Naltrexone results in increased expression of OGFR CTD PMID:21685240 NCBI chr 3:176,093,662...176,099,949
Ensembl chr 3:175,930,505...176,099,987
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Naltrexone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Naltrexone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
affects response to substance
ISO
EXP
[[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP
Naltrexone binds to OPRM1 protein
OPRM1 affects the susceptibility to Naltrexone
CTD PMID:7562497, PMID:11413242, PMID:18250251 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
affects response to substance
ISO Naltrexone inhibits the reaction [Enkephalin, Leucine-2-Alanine inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]]
SLC6A3 gene polymorphism affects the susceptibility to Naltrexone
CTD PMID:9765353, PMID:18552399 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Naltrexone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:15917999 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19718
      application 19363
        pharmaceutical 19235
          drug 19235
            protective agent 16342
              antidote 7622
                antidote to opioid poisoning 89
                  naloxone + 77
                  naloxone hydrochloride 0
                  naltrexone 19
                  naltrexone hydrochloride + 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.