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ONTOLOGY REPORT - ANNOTATIONS


Term:O-(chloroacetylcarbamoyl)fumagillol
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Accession:CHEBI:90748 term browser browse the term
Definition:A carbamate ester that is fumagillol in which the hydroxy group has been converted to the corresponding N-(chloroacetyl)carbamate derivative.
Synonyms:exact_synonym: (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl (chloroacetyl)carbamate
 related_synonym: (CHLOROACETYL)CARBAMIC ACID (3R,4S,5S,5R)-5-METHOXY-4-[(2R,3R)-2-METHYL-3-(3-METHYL-2-BUTENYL)OXIRANYL]-1-OXASPIRO[2.5]OCT-6-YL ESTER;   Agm 1470;   DRG-0148;   Formula=C19H28ClNO6;   InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1;   InChIKey=MSHZHSPISPJWHW-PVDLLORBSA-N;   O-chloroacetylcarbamoylfumagillol;   SMILES=[C@]1([C@]2(O[C@@]2(CC=C(C)C)[H])C)([H])[C@H](OC)[C@@H](CC[C@]13CO3)OC(=O)NC(=O)CCl;   TNP-470
 alt_id: CHEBI:47708
 xref: CAS:129298-91-5 "ChemIDplus";   DrugBank:DB08633;   LINCS:LSM-37119
 xref_mesh: MESH:C066515
 xref: PDBeChem:TN4;   PMID:11291554 "Europe PMC";   PMID:12114444 "Europe PMC";   PMID:15736572 "Europe PMC";   PMID:22510957 "Europe PMC";   PMID:25652463 "Europe PMC";   PMID:26254366 "Europe PMC";   PMID:26369821 "Europe PMC";   PMID:8616900 "Europe PMC";   PMID:8806471 "Europe PMC";   PMID:9059342 "Europe PMC";   PMID:9876375 "Europe PMC";   Reaxys:5358869 "Reaxys"


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O-(chloroacetylcarbamoyl)fumagillol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        antimicrobial agent 17151
          fumagillol 15
            O-(chloroacetylcarbamoyl)fumagillol 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  organic heteromonocyclic compound 16249
                                    saturated organic heteromonocyclic parent 5298
                                      oxirane 5259
                                        epoxide 5257
                                          spiro-epoxide 15
                                            fumagillol 15
                                              O-(chloroacetylcarbamoyl)fumagillol 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.