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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:AM-251
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Accession:CHEBI:90724 term browser browse the term
Definition:A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Synonyms:exact_synonym: 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide
 related_synonym: AM251;   Formula=C22H21Cl2IN4O;   InChI=1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30);   InChIKey=BUZAJRPLUGXRAB-UHFFFAOYSA-N;   SMILES=N=1N(C(=C(C1C(=O)NN2CCCCC2)C)C3=CC=C(C=C3)I)C4=CC=C(C=C4Cl)Cl
 xref: CAS:183232-66-8;   KEGG:C20220;   LINCS:LSM-4057
 xref_mesh: MESH:C103505
 xref: PMID:25445359;   PMID:25446756;   PMID:25447325;   PMID:25550281;   PMID:25575795;   PMID:25645684;   PMID:25656689;   PMID:25728242;   PMID:25769371;   PMID:25804605;   PMID:25843798;   PMID:25894754;   PMID:25974027;   PMID:26098470;   PMID:26126926;   PMID:26157003;   PMID:26292188;   PMID:26311003;   PMID:26363193;   PMID:26609670;   Reaxys:7780333;   Wikipedia:AM251



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AM-251 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases expression
ISO 4'-methoxy-1-naphthylfenoterol inhibits the reaction [AM 251 results in increased expression of ABCG2 protein]; 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [AM 251 results in increased expression of ABCG2 protein] CTD PMID:27423937 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO AM 251 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA] CTD PMID:27936102 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Agrp agouti related neuropeptide multiple interactions
increases expression
EXP AM 251 promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of AGRP mRNA]
AM 251 results in increased expression of AGRP mRNA
CTD PMID:26468265 NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO AM 251 inhibits the reaction [Cannabidiol results in increased phosphorylation of AKT1 protein]; AM 251 inhibits the reaction [Dronabinol results in decreased phosphorylation of and results in decreased activity of AKT1 protein]
AM 251 inhibits the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; AM 251 inhibits the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; AM 251 inhibits the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; AM 251 inhibits the reaction [Dietary Fats results in decreased expression of AKT1 protein]
CTD PMID:17583570 PMID:26847930 PMID:27543109 PMID:33817834 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Arpc4 actin related protein 2/3 complex, subunit 4 decreases expression ISO AM 251 results in decreased expression of ARPC4 mRNA CTD PMID:16500647 NCBI chr 4:146,522,255...146,532,784
Ensembl chr 4:146,522,176...146,532,785
JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 increases expression ISO AM 251 results in increased expression of ARPP21 mRNA CTD PMID:16500647 NCBI chr 8:112,034,636...112,199,273
Ensembl chr 8:112,034,642...112,194,297
JBrowse link
G Ass1 argininosuccinate synthase 1 increases expression ISO AM 251 results in increased expression of ASS1 mRNA CTD PMID:16500647 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Atf5 activating transcription factor 5 increases expression ISO AM 251 results in increased expression of ATF5 mRNA CTD PMID:16500647 NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707
JBrowse link
G Avp arginine vasopressin multiple interactions
increases expression
EXP AM 251 promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of AVP mRNA]
AM 251 results in increased expression of AVP mRNA
CTD PMID:26468265 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
ISO AM 251 results in increased expression of BCL2 protein
AM 251 inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]
CTD PMID:26967640 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions ISO AM 251 inhibits the reaction [anandamide results in decreased activity of BDKRB1 protein] CTD PMID:19022239 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO AM 251 inhibits the reaction [Morphine results in increased expression of BDNF protein] CTD PMID:27461790 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Btg2 BTG anti-proliferation factor 2 multiple interactions ISO AM 251 inhibits the reaction [Ethanol results in increased expression of BTG2 mRNA] CTD PMID:28095641 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G Cap2 cyclase associated actin cytoskeleton regulatory protein 2 decreases expression ISO AM 251 results in decreased expression of CAP2 mRNA CTD PMID:16500647 NCBI chr17:18,054,234...18,203,453
Ensembl chr17:18,054,431...18,203,373
JBrowse link
G Cars1 cysteinyl-tRNA synthetase 1 increases expression ISO AM 251 results in increased expression of CARS1 mRNA CTD PMID:16500647 NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941
JBrowse link
G Cartpt CART prepropeptide increases expression
multiple interactions
EXP AM 251 results in increased expression of CARTPT mRNA
[AM 251 co-treated with Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of CARTPT mRNA
CTD PMID:26468265 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
JBrowse link
G Casp1 caspase 1 multiple interactions ISO AM 251 inhibits the reaction [Cannabidiol inhibits the reaction [Lipopolysaccharides results in increased expression of CASP1 protein]] CTD PMID:34269108 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Cavin2 caveolae associated protein 2 decreases expression ISO AM 251 results in decreased expression of CAVIN2 mRNA CTD PMID:16500647 NCBI chr 9:50,302,079...50,314,096
Ensembl chr 9:50,301,206...50,314,147
JBrowse link
G Ccdc86 coiled-coil domain containing 86 decreases expression ISO AM 251 results in decreased expression of CCDC86 mRNA CTD PMID:16500647 NCBI chr 1:207,590,167...207,596,547
Ensembl chr 1:207,590,168...207,596,544
JBrowse link
G Ccnd2 cyclin D2 increases expression
multiple interactions
ISO AM 251 results in increased expression of CCND2 protein
AM 251 inhibits the reaction [Streptozocin results in decreased expression of CCND2 protein]
CTD PMID:26967640 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression ISO AM 251 results in increased expression of CD55 mRNA CTD PMID:16500647 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions
ISO AM 251 results in increased expression of CDH1 protein
AM 251 inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]
CTD PMID:27936102 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma increases expression ISO AM 251 results in increased expression of CEBPG mRNA CTD PMID:16500647 NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569
JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit increases expression ISO AM 251 results in increased expression of CHRNB3 mRNA CTD PMID:16500647 NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360
JBrowse link
G Cklf chemokine-like factor increases expression ISO AM 251 results in increased expression of CKLF mRNA CTD PMID:16500647 NCBI chr19:698,097...706,570
Ensembl chr19:698,033...706,570
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
decreases activity
increases methylation
ISO
EXP
[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 1-(5-fluoropentyl)-3-(1-naphthoyl)indole; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 1-pentyl-3-(1-naphthoyl)indole; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to CP 47497; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to CP 47497 analog; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to HU 211; AM 251 inhibits the reaction [Dietary Fats results in increased expression of CNR1 protein]; AM 251 inhibits the reaction [Ethanol results in increased expression of CNR1 mRNA]
[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased activity of nimesulide; AM 251 binds to and results in decreased activity of CNR1 protein; AM 251 inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in decreased expression of CNR1 mRNA]; AM 251 inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in decreased expression of CNR1 protein]; AM 251 inhibits the reaction [1-(cyclohexylmethyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester binds to and results in increased activity of CNR1 protein]; AM 251 inhibits the reaction [1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester binds to and results in increased activity of CNR1 protein]; AM 251 inhibits the reaction [Dietary Carbohydrates results in decreased expression of CNR1 protein]; AM 251 inhibits the reaction [HU 211 results in decreased expression of CNR1 protein]; AM 251 inhibits the reaction [Methylazoxymethanol Acetate results in increased expression of CNR1 mRNA]; AM 251 inhibits the reaction [N-(1-adamantyl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide binds to and results in increased activity of CNR1 protein]; AM 251 inhibits the reaction [N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide binds to and results in increased activity of CNR1 protein]
AM 251 results in decreased activity of CNR1 protein
AM 251 results in increased methylation of CNR1 promoter
AM 251 inhibits the reaction [Cannabidiol results in increased expression of CNR1 protein]
CTD PMID:12509806 PMID:17596442 PMID:20590570 PMID:21907772 PMID:24211273 More... NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO AM 251 inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] CTD PMID:27936102 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO AM 251 inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] CTD PMID:27936102 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions ISO AM 251 inhibits the reaction [TGFB1 protein results in increased expression of COL4A1 mRNA] CTD PMID:27936102 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions EXP AM 251 inhibits the reaction [Dietary Carbohydrates results in decreased expression of COX4I1 mRNA]; AM 251 inhibits the reaction [Dietary Fats results in decreased expression of COX4I1 mRNA] CTD PMID:26671069 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO AM 251 inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:26847930 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO AM 251 inhibits the reaction [Morphine results in increased phosphorylation of CREB1 protein] CTD PMID:27461790 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 multiple interactions
decreases expression
ISO AM 251 inhibits the reaction [Ethanol results in increased cleavage of and results in increased activity of CREB3L3 protein]; AM 251 inhibits the reaction [Ethanol results in increased expression of CREB3L3 mRNA]
AM 251 results in decreased expression of CREB3L3 mRNA
CTD PMID:23894352 NCBI chr 7:8,622,614...8,631,053
Ensembl chr 7:8,622,614...8,631,048
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases expression
EXP [AM 251 co-treated with Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of CRH mRNA
AM 251 results in increased expression of CRH mRNA
CTD PMID:26468265 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Cs citrate synthase multiple interactions ISO AM 251 inhibits the reaction [Dietary Fats results in decreased expression of CS mRNA] CTD PMID:26847930 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO AM 251 results in increased expression of CTH mRNA CTD PMID:16500647 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; AM 251 promotes the reaction [iodopravadoline inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]]; iodopravadoline promotes the reaction [AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]] CTD PMID:17484889 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions ISO AM 251 inhibits the reaction [Ethanol results in increased expression of CYP27A1 mRNA] CTD PMID:23894352 PMID:28095641 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO AM 251 inhibits the reaction [Ethanol results in increased expression of CYP7A1 mRNA] CTD PMID:23894352 PMID:28095641 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression
multiple interactions
ISO AM 251 results in decreased expression of CYP7B1 mRNA
AM 251 inhibits the reaction [Ethanol results in increased expression of CYP7B1 mRNA]
CTD PMID:23894352 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO AM 251 inhibits the reaction [Ethanol results in increased expression of CYP8B1 mRNA] CTD PMID:23894352 PMID:28095641 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO AM 251 results in increased expression of DDIT3 mRNA CTD PMID:16500647 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO AM 251 results in increased expression of DDIT4 mRNA CTD PMID:16500647 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Dhx9 DExH-box helicase 9 decreases expression ISO AM 251 results in decreased expression of DHX9 mRNA CTD PMID:16500647 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions
increases activity
decreases expression
EXP
ISO
AM 251 inhibits the reaction [Dietary Carbohydrates results in decreased expression of DLD mRNA]; AM 251 inhibits the reaction [Dietary Carbohydrates results in decreased expression of DLD protein]
AM 251 results in increased activity of DLD protein
AM 251 results in decreased expression of DLD mRNA
AM 251 promotes the reaction [INS1 protein results in increased activity of DLD protein]
CTD PMID:26671069 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795
JBrowse link
G Eftud2 elongation factor Tu GTP binding domain containing 2 decreases expression ISO AM 251 results in decreased expression of EFTUD2 mRNA CTD PMID:16500647 NCBI chr10:87,804,893...87,852,181
Ensembl chr10:87,804,892...87,846,079
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases expression
ISO 4'-methoxy-1-naphthylfenoterol inhibits the reaction [AM 251 results in increased expression of EGFR protein]; 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [AM 251 results in increased expression of EGFR protein] CTD PMID:27423937 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eno3 enolase 3 multiple interactions EXP AM 251 inhibits the reaction [Dietary Carbohydrates results in increased expression of ENO3 protein] CTD PMID:26671069 NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
JBrowse link
G Ervfrd-1 endogenous retrovirus group FRD member 1, envelope multiple interactions ISO AM 251 affects the reaction [Dronabinol results in decreased expression of ERVFRD-1 mRNA] CTD PMID:26070387 NCBI chr12:22,151,211...22,158,264
Ensembl chr12:22,151,211...22,158,264
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO [AM 251 co-treated with iodopravadoline] promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]; [AM 251 co-treated with iodopravadoline] promotes the reaction [methanandamide promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]] CTD PMID:27556861 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fen1 flap structure-specific endonuclease 1 decreases expression ISO AM 251 results in decreased expression of FEN1 mRNA CTD PMID:16500647 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO AM 251 inhibits the reaction [Dietary Fats results in increased expression of FOS protein]; AM 251 inhibits the reaction [LEP gene mutant form results in increased expression of FOS protein] CTD PMID:27071101 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO AM 251 inhibits the reaction [TGFB1 protein results in increased expression of FOSB mRNA]
AM 251 results in increased expression of FOSB mRNA
CTD PMID:27936102 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO AM 251 inhibits the reaction [Dietary Fats results in decreased phosphorylation of FOXO1 protein] CTD PMID:26847930 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Fra10ac1 FRA10A associated CGG repeat 1 increases expression ISO AM 251 results in increased expression of FRA10AC1 mRNA CTD PMID:16500647 NCBI chr 1:235,969,071...236,001,074
Ensembl chr 1:235,969,112...236,001,210
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO AM 251 inhibits the reaction [Dietary Fats results in increased expression of G6PC1 protein] CTD PMID:26847930 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G Glo1 glyoxalase 1 decreases expression
multiple interactions
EXP AM 251 results in decreased expression of GLO1 protein
AM 251 inhibits the reaction [Dietary Carbohydrates results in decreased expression of GLO1 protein]; AM 251 inhibits the reaction [Dietary Fats results in decreased expression of GLO1 protein]
CTD PMID:26671069 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Gpi glucose-6-phosphate isomerase multiple interactions
decreases expression
EXP AM 251 inhibits the reaction [Dietary Carbohydrates results in increased expression of GPI protein]
AM 251 results in decreased expression of GPI protein
CTD PMID:26671069 NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086
JBrowse link
G Gpr55 G protein-coupled receptor 55 multiple interactions
increases activity
ISO 4'-methoxy-1-naphthylfenoterol inhibits the reaction [AM 251 results in increased activity of GPR55 protein]; 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [AM 251 results in increased activity of GPR55 protein] CTD PMID:27423937 NCBI chr 9:86,584,906...86,640,601
Ensembl chr 9:86,590,885...86,640,613
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO AM 251 results in increased expression of GPX1 mRNA CTD PMID:16500647 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO AM 251 promotes the reaction [INS1 protein results in increased activity of GSR protein] CTD PMID:26671069 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gtf3c5 general transcription factor IIIC subunit 5 decreases expression ISO AM 251 results in decreased expression of GTF3C5 mRNA CTD PMID:16500647 NCBI chr 3:11,893,867...11,914,187
Ensembl chr 3:11,893,875...11,914,180
JBrowse link
G Hax1 HCLS1 associated protein X-1 increases expression ISO AM 251 results in increased expression of HAX1 mRNA CTD PMID:16500647 NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714
JBrowse link
G Hcrt hypocretin neuropeptide precursor multiple interactions EXP
ISO
AM 251 inhibits the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of HCRT mRNA]
AM 251 inhibits the reaction [Dietary Fats results in increased expression of HCRT protein modified form]; AM 251 inhibits the reaction [HCRT protein modified form results in increased expression of POMC mRNA]; AM 251 inhibits the reaction [HCRT protein modified form results in increased expression of POMC protein modified form]; AM 251 inhibits the reaction [HCRT protein modified form results in increased expression of POMC protein]; AM 251 inhibits the reaction [HCRT protein modified form results in increased phosphorylation of and results in increased activity of STAT3 protein]; AM 251 inhibits the reaction [HCRT protein modified form results in increased phosphorylation of MAPK1 protein]; AM 251 inhibits the reaction [HCRT protein modified form results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [LEP gene mutant form results in increased expression of HCRT protein modified form]
CTD PMID:26468265 PMID:27071101 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210
JBrowse link
G Hist1h2al1 histone cluster 1 H2A family like 1 increases expression ISO AM 251 results in increased expression of H2AC6 mRNA CTD PMID:16500647 NCBI chr17:42,707,954...42,708,420 JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO AM 251 results in increased expression of HMOX1 mRNA CTD PMID:16500647 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnmt histamine N-methyltransferase increases expression ISO AM 251 results in increased expression of HNMT mRNA CTD PMID:16500647 NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression ISO AM 251 results in decreased expression of HSPA1B mRNA CTD PMID:16500647 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO AM 251 results in decreased expression of HSPA8 mRNA CTD PMID:16500647 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO AM 251 inhibits the reaction [Cannabidiol results in increased expression of ICAM1 mRNA] CTD PMID:22198381 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [AM 251 co-treated with iodopravadoline] promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]; [AM 251 co-treated with iodopravadoline] promotes the reaction [methanandamide promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]] CTD PMID:27556861 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il33 interleukin 33 multiple interactions EXP AM 251 inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL33 protein]] CTD PMID:31732924 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Immp2l inner mitochondrial membrane peptidase subunit 2 increases expression ISO AM 251 results in increased expression of IMMP2L mRNA CTD PMID:16500647 NCBI chr 6:58,070,035...58,970,165
Ensembl chr 6:58,070,283...58,969,840
JBrowse link
G Ins1 insulin 1 multiple interactions ISO AM 251 inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; AM 251 promotes the reaction [INS1 protein results in increased activity of DLD protein]; AM 251 promotes the reaction [INS1 protein results in increased activity of GSR protein] CTD PMID:26671069 PMID:26967640 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Irf2bpl interferon regulatory factor 2 binding protein-like increases expression ISO AM 251 results in increased expression of IRF2BPL mRNA CTD PMID:16500647 NCBI chr 6:106,527,179...106,531,294
Ensembl chr 6:106,528,053...106,530,401
JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO AM 251 inhibits the reaction [Dietary Fats results in decreased phosphorylation of IRS2 protein] CTD PMID:26847930 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO AM 251 inhibits the reaction [TGFB1 protein results in increased expression of JUNB mRNA] CTD PMID:27936102 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP AM 251 inhibits the reaction [Dietary Carbohydrates results in increased expression of LDHA protein] CTD PMID:26671069 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Lep leptin multiple interactions ISO AM 251 inhibits the reaction [LEP gene mutant form results in decreased expression of POMC mRNA]; AM 251 inhibits the reaction [LEP gene mutant form results in decreased expression of POMC protein]; AM 251 inhibits the reaction [LEP gene mutant form results in decreased secretion of POMC protein modified form]; AM 251 inhibits the reaction [LEP gene mutant form results in increased expression of FOS protein]; AM 251 inhibits the reaction [LEP gene mutant form results in increased expression of HCRT protein modified form] CTD PMID:27071101 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lmnb2 lamin B2 decreases expression ISO AM 251 results in decreased expression of LMNB2 mRNA CTD PMID:16500647 NCBI chr 7:8,792,628...8,808,665
Ensembl chr 7:8,789,314...8,808,665
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 decreases expression ISO AM 251 results in decreased expression of MAP2K3 mRNA CTD PMID:16500647 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO AM 251 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; AM 251 inhibits the reaction [Dronabinol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; AM 251 inhibits the reaction [Dronabinol results in increased phosphorylation of MAPK1 protein]; AM 251 inhibits the reaction [methanandamide results in increased phosphorylation of MAPK1 protein]
AM 251 results in increased phosphorylation of MAPK1 protein
AM 251 inhibits the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; AM 251 inhibits the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; AM 251 inhibits the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; AM 251 inhibits the reaction [HCRT protein modified form results in increased phosphorylation of MAPK1 protein]; AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
CTD PMID:17583570 PMID:17596442 PMID:18159069 PMID:19477951 PMID:27071101 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO AM 251 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; AM 251 inhibits the reaction [Dronabinol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; AM 251 inhibits the reaction [Dronabinol results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [methanandamide results in increased phosphorylation of MAPK3 protein]
AM 251 results in increased phosphorylation of MAPK3 protein
AM 251 inhibits the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [HCRT protein modified form results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
CTD PMID:17583570 PMID:17596442 PMID:18159069 PMID:19477951 PMID:27071101 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO AM 251 results in decreased expression of MCM3 mRNA CTD PMID:16500647 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 decreases expression ISO AM 251 results in decreased expression of MCM5 mRNA CTD PMID:16500647 NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389
JBrowse link
G Mfn2 mitofusin 2 decreases expression ISO AM 251 results in decreased expression of MFN2 mRNA CTD PMID:16500647 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression
ISO AM 251 inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]
AM 251 results in increased expression of MMP2 protein
CTD PMID:27936102 PMID:29883990 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Ncapd3 non-SMC condensin II complex, subunit D3 decreases expression ISO AM 251 results in decreased expression of NCAPD3 mRNA CTD PMID:16500647 NCBI chr 8:25,437,067...25,506,375
Ensembl chr 8:25,437,123...25,506,373
JBrowse link
G Ncoa7 nuclear receptor coactivator 7 increases expression ISO AM 251 results in increased expression of NCOA7 mRNA CTD PMID:16500647 NCBI chr 1:26,856,228...27,016,950
Ensembl chr 1:26,856,530...27,015,871
JBrowse link
G Npy neuropeptide Y multiple interactions EXP [AM 251 co-treated with Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of NPY mRNA CTD PMID:26468265 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions ISO AM 251 inhibits the reaction [Dietary Fats results in decreased expression of NRF1 mRNA] CTD PMID:26847930 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 multiple interactions ISO AM 251 inhibits the reaction [Dronabinol results in decreased expression of OPRL1 mRNA]; AM 251 inhibits the reaction [Dronabinol results in decreased expression of OPRL1 protein] CTD PMID:21603976 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide multiple interactions
increases expression
increases secretion
EXP AM 251 promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of OXT mRNA]
AM 251 results in increased expression of OXT mRNA
AM 251 results in increased secretion of OXT protein
CTD PMID:26468265 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
JBrowse link
G Papola poly (A) polymerase alpha decreases expression ISO AM 251 results in decreased expression of PAPOLA mRNA CTD PMID:16500647 NCBI chr 6:124,682,015...124,734,706
Ensembl chr 6:124,682,105...124,734,468
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO AM 251 inhibits the reaction [HU 211 results in increased cleavage of PARP1 protein] CTD PMID:19509271 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO AM 251 inhibits the reaction [Dietary Fats results in increased expression of PCK1 mRNA]; AM 251 inhibits the reaction [Dietary Fats results in increased expression of PCK1 protein] CTD PMID:26847930 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 increases expression ISO AM 251 results in increased expression of PEA15 mRNA CTD PMID:16500647 NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases expression
EXP
ISO
AM 251 promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of POMC mRNA]
AM 251 results in increased expression of POMC mRNA
AM 251 inhibits the reaction [Dietary Fats results in decreased expression of POMC mRNA]; AM 251 inhibits the reaction [Dietary Fats results in decreased expression of POMC protein]; AM 251 inhibits the reaction [Dietary Fats results in decreased secretion of POMC protein modified form]; AM 251 inhibits the reaction [HCRT protein modified form results in increased expression of POMC mRNA]; AM 251 inhibits the reaction [HCRT protein modified form results in increased expression of POMC protein modified form]; AM 251 inhibits the reaction [HCRT protein modified form results in increased expression of POMC protein]; AM 251 inhibits the reaction [LEP gene mutant form results in decreased expression of POMC mRNA]; AM 251 inhibits the reaction [LEP gene mutant form results in decreased expression of POMC protein]; AM 251 inhibits the reaction [LEP gene mutant form results in decreased secretion of POMC protein modified form]
CTD PMID:26468265 PMID:27071101 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ppif peptidylprolyl isomerase F decreases expression ISO AM 251 results in decreased expression of PPIF mRNA CTD PMID:16500647 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913
JBrowse link
G Ptbp1 polypyrimidine tract binding protein 1 decreases expression ISO AM 251 results in decreased expression of PTBP1 mRNA CTD PMID:16500647 NCBI chr 7:9,842,574...9,852,332
Ensembl chr 7:9,842,574...9,852,397
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO [AM 251 co-treated with iodopravadoline] inhibits the reaction [Dronabinol results in increased phosphorylation of PTK2 protein] CTD PMID:31461164 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 decreases expression ISO AM 251 results in decreased expression of RACGAP1 mRNA CTD PMID:16500647 NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831
JBrowse link
G Rad54l RAD54 like decreases expression ISO AM 251 results in decreased expression of RAD54L mRNA CTD PMID:16500647 NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070
JBrowse link
G Rcc1 regulator of chromosome condensation 1 decreases expression ISO AM 251 results in decreased expression of RCC1 mRNA CTD PMID:16500647 NCBI chr 5:144,526,025...144,544,445
Ensembl chr 5:144,526,025...144,544,577
JBrowse link
G Rcc1l RCC1 like decreases expression ISO AM 251 results in decreased expression of RCC1L mRNA CTD PMID:16500647 NCBI chr12:22,543,125...22,574,042
Ensembl chr12:22,543,734...22,574,036
JBrowse link
G Rfc5 replication factor C subunit 5 decreases expression ISO AM 251 results in decreased expression of RFC5 mRNA CTD PMID:16500647 NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312
JBrowse link
G Rnaseh1 ribonuclease H1 increases expression ISO AM 251 results in increased expression of RNASEH1 mRNA CTD PMID:16500647 NCBI chr 6:45,282,849...45,292,258
Ensembl chr 6:45,282,854...45,292,236
JBrowse link
G Rpa1 replication protein A1 decreases expression ISO AM 251 results in decreased expression of RPA1 mRNA CTD PMID:16500647 NCBI chr10:60,148,869...60,199,970
Ensembl chr10:60,148,793...60,199,949
JBrowse link
G Rwdd1 RWD domain containing 1 increases expression ISO AM 251 results in increased expression of RWDD1 mRNA CTD PMID:16500647 NCBI chr20:25,949,723...25,967,147
Ensembl chr20:25,941,966...25,967,193
JBrowse link
G S100a2 S100 calcium binding protein A2 increases expression ISO AM 251 results in increased expression of S100A2 mRNA CTD PMID:16500647 NCBI chr 2:176,077,081...176,078,325 JBrowse link
G Sars1 seryl-tRNA synthetase 1 increases expression ISO AM 251 results in increased expression of SARS1 mRNA CTD PMID:16500647 NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277
JBrowse link
G Sesn2 sestrin 2 increases expression ISO AM 251 results in increased expression of SESN2 mRNA CTD PMID:16500647 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Slc18b1 solute carrier family 18 member B1 decreases expression ISO AM 251 results in decreased expression of SLC18B1 mRNA CTD PMID:16500647 NCBI chr 1:21,628,235...21,670,807
Ensembl chr 1:21,628,237...21,670,684
JBrowse link
G Slc1a4 solute carrier family 1 member 4 increases expression ISO AM 251 results in increased expression of SLC1A4 mRNA CTD PMID:16500647 NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418
JBrowse link
G Slc30a1 solute carrier family 30 member 1 increases expression ISO AM 251 results in increased expression of SLC30A1 mRNA CTD PMID:16500647 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
JBrowse link
G Slc46a1 solute carrier family 46 member 1 increases expression ISO AM 251 results in increased expression of SLC46A1 mRNA CTD PMID:19145103 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions EXP AM 251 affects the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone affects the expression of SLC6A3 mRNA] CTD PMID:29113897 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO AM 251 results in increased expression of SLC7A5 mRNA CTD PMID:16500647 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO AM 251 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:27936102 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression
multiple interactions
ISO AM 251 results in decreased expression of SNAI1 mRNA
AM 251 inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]
CTD PMID:27936102 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO AM 251 inhibits the reaction [TGFB1 protein results in increased expression of SNAI2 mRNA] CTD PMID:27936102 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 decreases expression ISO AM 251 results in decreased expression of SPTBN1 mRNA CTD PMID:16500647 NCBI chr14:103,841,713...104,016,900
Ensembl chr14:103,842,684...104,008,507
JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 decreases expression ISO AM 251 results in decreased expression of SRSF1 mRNA CTD PMID:16500647 NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336
JBrowse link
G Stam signal transducing adaptor molecule decreases expression ISO AM 251 results in decreased expression of STAM mRNA CTD PMID:16500647 NCBI chr17:77,120,235...77,166,173
Ensembl chr17:77,120,158...77,166,467
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression
multiple interactions
ISO AM 251 results in decreased expression of STAT3 mRNA
AM 251 inhibits the reaction [HCRT protein modified form results in increased phosphorylation of and results in increased activity of STAT3 protein]
AM 251 inhibits the reaction [Cannabidiol results in increased phosphorylation of STAT3 protein]
CTD PMID:16500647 PMID:27071101 PMID:33817834 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Sugp2 SURP and G patch domain containing 2 decreases expression ISO AM 251 results in decreased expression of SUGP2 mRNA CTD PMID:16500647 NCBI chr16:19,159,951...19,191,412
Ensembl chr16:19,164,767...19,191,340
JBrowse link
G Sun1 Sad1 and UNC84 domain containing 1 decreases expression ISO AM 251 results in decreased expression of SUN1 mRNA CTD PMID:16500647 NCBI chr12:15,396,378...15,441,277
Ensembl chr12:15,396,381...15,441,571
JBrowse link
G Tacc3 transforming, acidic coiled-coil containing protein 3 decreases expression ISO AM 251 results in decreased expression of TACC3 mRNA CTD PMID:16500647 NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219
JBrowse link
G Tbl1x transducin (beta)-like 1 X-linked increases expression ISO AM 251 results in increased expression of TBL1X mRNA CTD PMID:16500647 NCBI chr  X:41,574,558...41,731,117
Ensembl chr  X:41,576,047...41,731,101
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions ISO AM 251 inhibits the reaction [Dietary Fats results in decreased expression of TFAM mRNA] CTD PMID:26847930 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO AM 251 inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of COL4A1 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of FOSB mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of JUNB mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of SNAI2 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of TGFB2 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of TGFB3 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of TGFBR1 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:27936102 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO AM 251 inhibits the reaction [TGFB1 protein results in increased expression of TGFB2 mRNA] CTD PMID:27936102 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions ISO AM 251 inhibits the reaction [TGFB1 protein results in increased expression of TGFB3 mRNA] CTD PMID:27936102 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions ISO AM 251 inhibits the reaction [TGFB1 protein results in increased expression of TGFBR1 mRNA] CTD PMID:27936102 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP AM 251 affects the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone affects the expression of TH mRNA] CTD PMID:29113897 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO [iodopravadoline co-treated with AM 251] inhibits the reaction [Dronabinol results in increased expression of TIMP1 protein]; [iodopravadoline co-treated with AM 251] inhibits the reaction [methanandamide results in increased expression of TIMP1 protein]; AM 251 inhibits the reaction [Dronabinol results in increased expression of TIMP1 protein]; AM 251 inhibits the reaction [methanandamide results in increased expression of TIMP1 protein] CTD PMID:18159069 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tmem126a transmembrane protein 126A increases expression ISO AM 251 results in increased expression of TMEM126A mRNA CTD PMID:16500647 NCBI chr 1:144,424,481...144,430,730
Ensembl chr 1:144,422,703...144,430,628
JBrowse link
G Tnf tumor necrosis factor decreases response to substance ISO AM 251 results in decreased susceptibility to TNF protein CTD PMID:20626112 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO AM 251 results in increased expression of TRIB3 mRNA CTD PMID:16500647 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
JBrowse link
G Tspan10 tetraspanin 10 increases expression ISO AM 251 results in increased expression of TSPAN10 mRNA CTD PMID:16500647 NCBI chr10:105,715,803...105,721,503
Ensembl chr10:105,715,961...105,719,813
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO AM 251 results in increased expression of TXNIP mRNA CTD PMID:16500647 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase decreases expression ISO AM 251 results in decreased expression of UGCG mRNA CTD PMID:16500647 NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393
JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 decreases expression ISO AM 251 results in decreased expression of UHRF1 mRNA CTD PMID:16500647 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO AM 251 inhibits the reaction [arachidonyl-2-chloroethylamide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of VEGFA protein]] CTD PMID:26467187 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vegfc vascular endothelial growth factor C multiple interactions ISO AM 251 inhibits the reaction [arachidonyl-2-chloroethylamide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of VEGFC protein]] CTD PMID:26467187 NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848
JBrowse link
G Vldlr very low density lipoprotein receptor increases expression ISO AM 251 results in increased expression of VLDLR mRNA CTD PMID:16500647 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression ISO AM 251 results in increased expression of WARS1 mRNA CTD PMID:16500647 NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269
JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO AM 251 results in increased expression of XBP1 mRNA CTD PMID:16500647 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 increases expression ISO AM 251 results in increased expression of YARS1 mRNA CTD PMID:16500647 NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833
JBrowse link
G Yy1 YY1 transcription factor multiple interactions ISO AM 251 inhibits the reaction [Ethanol results in increased expression of YY1 mRNA] CTD PMID:28095641 NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747
JBrowse link
G Zfp142 zinc finger protein 142 decreases expression ISO AM 251 results in decreased expression of ZNF142 mRNA CTD PMID:16500647 NCBI chr 9:76,141,053...76,164,784
Ensembl chr 9:76,142,227...76,164,856
JBrowse link
G Zmym6 zinc finger MYM-type containing 6 increases expression ISO AM 251 results in increased expression of ZMYM6 mRNA CTD PMID:16500647 NCBI chr 5:139,396,374...139,444,357
Ensembl chr 5:139,396,727...139,444,279
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        biochemical role 19588
          apoptosis inducer 13641
            AM-251 152
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        carboacyl group 17727
                                          univalent carboacyl group 17727
                                            carbamoyl group 17575
                                              carboxamide 17575
                                                monocarboxylic acid amide 15699
                                                  amidopiperidine 444
                                                    AM-251 152
paths to the root