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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-[3-(aminomethyl)benzyl]acetamidine
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Accession:CHEBI:90721 term browser browse the term
Definition:An aralkylamine that is Nbenzylacetamidine substituted at position 3 on the benzene ring by an aminomethyl group. An inhibitor of nitric oxide synthase.
Synonyms:exact_synonym: N-{[3-(aminomethyl)phenyl]methyl}ethanimidamide
 related_synonym: 1400 W;   1400W;   Formula=C10H15N3;   InChI=1S/C10H15N3/c1-8(12)13-7-10-4-2-3-9(5-10)6-11/h2-5H,6-7,11H2,1H3,(H2,12,13);   InChIKey=RODUKNYOEVZQPR-UHFFFAOYSA-N;   SMILES=C(=N)(NCC1=CC(=CC=C1)CN)C;   W1400
 xref: DrugBank:DB02044
 xref_mesh: MESH:C104820
 xref: PDBeChem:14W;   PMID:11459438;   PMID:25619924;   PMID:26362773;   PMID:26526764;   Reaxys:8054187


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N-[3-(aminomethyl)benzyl]acetamidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt2 thymoma viral proto-oncogene 2 affects response to substance EXP AKT2 protein affects the susceptibility to N-(3-(aminomethyl)benzyl)acetamidine CTD PMID:21964073 NCBI chr 7:27,591,552...27,640,826
Ensembl chr 7:27,591,552...27,640,826
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 multiple interactions EXP [N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein] CTD PMID:19442826 NCBI chr 7:138,890,836...138,909,506
Ensembl chr 7:138,890,836...138,909,519
JBrowse link
G Cav1 caveolin 1, caveolae protein multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Oxygen deficiency results in increased expression of CAV1 protein] CTD PMID:18717816 NCBI chr 6:17,306,335...17,341,328
Ensembl chr 6:17,306,335...17,341,452
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein] CTD PMID:15542068 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein] CTD PMID:15542068 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA] CTD PMID:18206661 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Oxidopamine results in increased expression of HMOX1 protein] CTD PMID:21397656 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Ifng interferon gamma multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein] CTD PMID:11076874 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein] CTD PMID:11076874 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Ins1 insulin I increases response to substance EXP N-(3-(aminomethyl)benzyl)acetamidine results in increased susceptibility to INS1 protein CTD PMID:21964073 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476
JBrowse link
G Itgb2 integrin beta 2 multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP2A protein] CTD PMID:16963453 NCBI chr10:77,530,329...77,565,708
Ensembl chr10:77,530,252...77,565,708
JBrowse link
G Lepr leptin receptor increases response to substance ISO LEPR gene mutant form results in increased susceptibility to N-(3-(aminomethyl)benzyl)acetamidine CTD PMID:30689673 NCBI chr 4:101,717,137...101,815,352
Ensembl chr 4:101,717,404...101,815,352
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:11504810 PMID:11713966 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
decreases activity
ISO
EXP
[N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [fluvastatin results in increased abundance of Nitric Oxide]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]
[N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] which results in increased susceptibility to endothelium-dependent hyperpolarization factor; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Potassium Cyanide results in increased expression of NOS2 protein]
[N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased chemical synthesis of Reactive Oxygen Species]; [N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]
CTD PMID:11076874 PMID:11134894 PMID:16461118 PMID:16933320 PMID:19442826 PMID:19951519 PMID:20035746 PMID:20497644 PMID:20549418 PMID:23061969 PMID:24964743 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Rap1a RAS-related protein 1a multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein] CTD PMID:16963453 NCBI chr 3:105,727,260...105,801,394
Ensembl chr 3:105,727,267...105,801,336
JBrowse link
G Rap2a RAS related protein 2a multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP2A protein] CTD PMID:16963453 NCBI chr14:120,478,461...120,507,194
Ensembl chr14:120,478,444...120,507,194
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [GGTI 298 results in decreased expression of TFRC protein] CTD PMID:24964743 NCBI chr16:32,608,896...32,632,794
Ensembl chr16:32,608,920...32,632,794
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein] CTD PMID:11076874 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link

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  CHEBI ontology 21552
    role 21530
      application 21016
        refrigerant 18607
          ammonia 17722
            organic amino compound 17721
              primary amino compound 7930
                N-[3-(aminomethyl)benzyl]acetamidine 18
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  CHEBI ontology 21552
    subatomic particle 21537
      composite particle 21537
        hadron 21537
          baryon 21537
            nucleon 21537
              atomic nucleus 21537
                atom 21537
                  main group element atom 21442
                    main group molecular entity 21442
                      s-block molecular entity 20953
                        hydrogen molecular entity 20879
                          hydrides 20094
                            inorganic hydride 18047
                              pnictogen hydride 18009
                                nitrogen hydride 17829
                                  azane 17723
                                    ammonia 17722
                                      organic amino compound 17721
                                        amine 7825
                                          alkylamines 185
                                            aralkylamine 164
                                              N-[3-(aminomethyl)benzyl]acetamidine 18
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