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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-[3-(aminomethyl)benzyl]acetamidine
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Accession:CHEBI:90721 term browser browse the term
Definition:An aralkylamine that is Nbenzylacetamidine substituted at position 3 on the benzene ring by an aminomethyl group. An inhibitor of nitric oxide synthase.
Synonyms:exact_synonym: N-{[3-(aminomethyl)phenyl]methyl}ethanimidamide
 related_synonym: 1400 W;   1400W;   Formula=C10H15N3;   InChI=1S/C10H15N3/c1-8(12)13-7-10-4-2-3-9(5-10)6-11/h2-5H,6-7,11H2,1H3,(H2,12,13);   InChIKey=RODUKNYOEVZQPR-UHFFFAOYSA-N;   SMILES=C(=N)(NCC1=CC(=CC=C1)CN)C;   W1400
 xref: DrugBank:DB02044
 xref_mesh: MESH:C104820
 xref: PDBeChem:14W;   PMID:11459438;   PMID:25619924;   PMID:26362773;   PMID:26526764;   Reaxys:8054187


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N-[3-(aminomethyl)benzyl]acetamidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT2 AKT serine/threonine kinase 2 affects response to substance ISO AKT2 protein affects the susceptibility to N-(3-(aminomethyl)benzyl)acetamidine CTD PMID:21964073 NCBI chr19:40,230,317...40,285,531
Ensembl chr19:40,230,317...40,285,536
JBrowse link
G BNIP3 BCL2 interacting protein 3 multiple interactions ISO [N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein] CTD PMID:19442826 NCBI chr10:131,967,683...131,982,013
Ensembl chr10:131,966,455...131,982,013
JBrowse link
G CAV1 caveolin 1 multiple interactions EXP N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Oxygen deficiency results in increased expression of CAV1 protein] CTD PMID:18717816 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,525,001...116,561,184
Ensembl chr 7:116,525,001...116,561,184
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein] CTD PMID:15542068 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein] CTD PMID:15542068 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions EXP N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA] CTD PMID:18206661 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Oxidopamine results in increased expression of HMOX1 protein] CTD PMID:21397656 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G IFNG interferon gamma multiple interactions EXP N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein] CTD PMID:11076874 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein] CTD PMID:11076874 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G ITGB2 integrin subunit beta 2 multiple interactions EXP N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP2A protein] CTD PMID:16963453 NCBI chr21:44,885,949...44,928,815
Ensembl chr21:44,885,953...44,931,989
JBrowse link
G LEPR leptin receptor increases response to substance ISO LEPR gene mutant form results in increased susceptibility to N-(3-(aminomethyl)benzyl)acetamidine CTD PMID:30689673 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G MPO myeloperoxidase multiple interactions ISO N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:11504810 PMID:11713966 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
decreases activity
EXP
ISO
[N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [fluvastatin results in increased abundance of Nitric Oxide]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]
[N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] which results in increased susceptibility to endothelium-dependent hyperpolarization factor; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Potassium Cyanide results in increased expression of NOS2 protein]
[N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased chemical synthesis of Reactive Oxygen Species]; [N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]
CTD PMID:11076874 PMID:11134894 PMID:16461118 PMID:16933320 PMID:19442826 PMID:19951519 PMID:20035746 PMID:20497644 PMID:20549418 PMID:23061969 PMID:24964743 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G RAP1A RAP1A, member of RAS oncogene family multiple interactions EXP N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein] CTD PMID:16963453 NCBI chr 1:111,542,009...111,716,695
Ensembl chr 1:111,542,218...111,716,691
JBrowse link
G RAP2A RAP2A, member of RAS oncogene family multiple interactions EXP N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP2A protein] CTD PMID:16963453 NCBI chr13:97,434,169...97,469,128
Ensembl chr13:97,434,169...97,469,128
JBrowse link
G TFRC transferrin receptor multiple interactions EXP N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [GGTI 298 results in decreased expression of TFRC protein] CTD PMID:24964743 NCBI chr 3:196,018,694...196,082,123
Ensembl chr 3:196,027,183...196,082,096
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein] CTD PMID:11076874 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 24381
    role 24291
      application 23783
        refrigerant 19183
          ammonia 18689
            organic amino compound 18688
              primary amino compound 8463
                N-[3-(aminomethyl)benzyl]acetamidine 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 24381
    subatomic particle 24338
      composite particle 24338
        hadron 24338
          baryon 24338
            nucleon 24338
              atomic nucleus 24338
                atom 24338
                  main group element atom 24185
                    main group molecular entity 24185
                      s-block molecular entity 23449
                        hydrogen molecular entity 23279
                          hydrides 21914
                            inorganic hydride 19157
                              pnictogen hydride 19129
                                nitrogen hydride 18808
                                  azane 18690
                                    ammonia 18689
                                      organic amino compound 18688
                                        amine 7928
                                          alkylamines 182
                                            aralkylamine 162
                                              N-[3-(aminomethyl)benzyl]acetamidine 17
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