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G |
Cd68 |
Cd68 molecule |
increases expression |
ISO |
retinoic acid receptor antagonist LE135 increases expression of CD68 protein in colonic lamina propria of DSS-induced colitis mice |
RGD |
PMID:25004394 |
RGD:40925931 |
NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
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G |
Ccnd1 |
cyclin D1 |
increases expression |
ISO |
O-(chloroacetylcarbamoyl)fumagillol results in increased expression of CCND1 protein |
CTD |
PMID:15276080 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
O-(chloroacetylcarbamoyl)fumagillol results in increased expression of CDKN1A protein |
CTD |
PMID:15276080 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Fgf2 |
fibroblast growth factor 2 |
multiple interactions decreases expression |
ISO |
[O-(chloroacetylcarbamoyl)fumagillol co-treated with docetaxel] results in decreased expression of FGF2 protein O-(chloroacetylcarbamoyl)fumagillol results in decreased expression of FGF2 protein |
CTD |
PMID:12576464 |
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NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
[O-(chloroacetylcarbamoyl)fumagillol co-treated with docetaxel] results in decreased expression of MMP9 protein |
CTD |
PMID:12576464 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
EXP |
O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:16061884 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of NOS2 protein] |
CTD |
PMID:16061884 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Rb1 |
RB transcriptional corepressor 1 |
decreases phosphorylation |
ISO |
O-(chloroacetylcarbamoyl)fumagillol results in decreased phosphorylation of RB1 protein |
CTD |
PMID:15276080 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:16061884 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein] |
CTD |
PMID:17761372 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
O-(chloroacetylcarbamoyl)fumagillol results in increased expression of TP53 protein |
CTD |
PMID:15276080 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Bco1 |
beta-carotene oxygenase 1 |
increases expression |
ISO |
Ro 41-5253 results in increased expression of BCO1 mRNA; Ro 41-5253 results in increased expression of BCO1 protein |
CTD |
PMID:16186334 |
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NCBI chr19:45,149,250...45,186,102
Ensembl chr19:45,149,265...45,186,101
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G |
Ccnd3 |
cyclin D3 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]] |
CTD |
PMID:17209053 |
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NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Ccne1 |
cyclin E1 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCNE1 protein]] |
CTD |
PMID:12421932 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Cd1d1 |
CD1d1 molecule |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CD1D mRNA]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of CD1D mRNA] |
CTD |
PMID:17392484 |
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NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDKN1B protein]] |
CTD |
PMID:12421932 |
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cyp26a1 |
cytochrome P450, family 26, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid results in increased expression of CYP26A1 mRNA]; Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CYP26A1 mRNA] |
CTD |
PMID:10953040 |
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NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
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G |
Fabp4 |
fatty acid binding protein 4 |
increases expression |
ISO |
Ro 41-5253 results in increased expression of FABP4 mRNA |
CTD |
PMID:17290005 |
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NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Fth1 |
ferritin heavy chain 1 |
multiple interactions |
EXP |
Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of FTH1 mRNA] |
CTD |
PMID:22154532 |
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NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]; Ro 41-5253 inhibits the reaction [beta Carotene results in increased expression of GJA1 protein] |
CTD |
PMID:16091010 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [IFNG protein promotes the reaction [Tretinoin results in increased expression of MUC4 protein]]; Ro 41-5253 inhibits the reaction [IFNG protein results in increased expression of MUC4 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of IFNG protein] |
CTD |
PMID:16007204 PMID:16872382 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Ifngr1 |
interferon gamma receptor 1 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IFNGR1 protein] |
CTD |
PMID:16085646 |
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NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin results in increased secretion of IL10 protein] |
CTD |
PMID:16872382 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12a |
interleukin 12A |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:16872382 |
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NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:16872382 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin results in increased secretion of IL4 protein] |
CTD |
PMID:16872382 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
[Dexamethasone co-treated with INS protein co-treated with Ro 41-5253] results in increased expression of PPARG protein |
CTD |
PMID:17290005 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Ireb2 |
iron responsive element binding protein 2 |
multiple interactions |
EXP |
Ro 41-5253 inhibits the reaction [Tretinoin results in decreased expression of IREB2 mRNA] |
CTD |
PMID:22154532 |
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NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611
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G |
Irf1 |
interferon regulatory factor 1 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IRF1 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of IRF1 protein] |
CTD |
PMID:16085646 PMID:16636311 |
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NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
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G |
Muc4 |
mucin 4, cell surface associated |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [IFNG protein promotes the reaction [Tretinoin results in increased expression of MUC4 protein]]; Ro 41-5253 inhibits the reaction [IFNG protein results in increased expression of MUC4 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of MUC4 protein] |
CTD |
PMID:16007204 |
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NCBI chr11:68,008,245...68,053,242
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G |
Nfatc1 |
nuclear factor of activated T-cells 1 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]] |
CTD |
PMID:17291456 |
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NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
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G |
Oas2 |
2'-5' oligoadenylate synthetase 2 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of OAS2 mRNA]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of OAS2 mRNA] |
CTD |
PMID:16636311 |
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NCBI chr12:35,802,824...35,830,778
Ensembl chr12:35,806,759...35,829,371
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G |
Plat |
plasminogen activator, tissue type |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Retinoids results in increased expression of PLAT] |
CTD |
PMID:7556191 |
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NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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G |
Ppard |
peroxisome proliferator-activated receptor delta |
affects binding multiple interactions |
ISO |
Ro 41-5253 binds to PPARD protein Ro 41-5253 inhibits the reaction [GW 2433 binds to PPARD protein] |
CTD |
PMID:17290005 |
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NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
[Dexamethasone co-treated with INS protein co-treated with Ro 41-5253] results in increased expression of PPARG protein; Ro 41-5253 binds to and results in increased activity of PPARG protein; Ro 41-5253 inhibits the reaction [pioglitazone results in increased activity of PPARG protein]; Ro 41-5253 inhibits the reaction [rosiglitazone binds to PPARG protein] [Dexamethasone co-treated with INS protein co-treated with Ro 41-5253] results in increased expression of PPARG protein; Ro 41-5253 results in increased activity of and results in decreased expression of PPARG protein |
CTD |
PMID:17290005 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Rara |
retinoic acid receptor, alpha |
multiple interactions decreases activity increases response to substance |
ISO |
Am 580 inhibits the reaction [Ro 41-5253 results in decreased activity of RARA protein]; Ro 41-5253 binds to and results in decreased activity of RARA protein; Ro 41-5253 inhibits the reaction [[RARA protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of RARA mRNA] RARA protein results in increased susceptibility to Ro 41-5253 |
CTD |
PMID:7556191 PMID:8838863 PMID:10779427 PMID:17216566 PMID:17290005 PMID:25550158 More...
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NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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G |
Rarb |
retinoic acid receptor, beta |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [[RARB protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA] |
CTD |
PMID:25550158 |
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NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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G |
Rarg |
retinoic acid receptor, gamma |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [[RARG protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA] |
CTD |
PMID:25550158 |
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NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
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G |
Rb1 |
RB transcriptional corepressor 1 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RB1 protein]] |
CTD |
PMID:12421932 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Rxra |
retinoid X receptor alpha |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [[RARA protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARB protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARG protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA] |
CTD |
PMID:25550158 |
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NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Slc10a1 |
solute carrier family 10 member 1 |
multiple interactions increases response to substance decreases expression |
ISO |
Ro 41-5253 inhibits the reaction [[RARA protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARB protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARG protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA] SLC10A1 protein results in increased susceptibility to Ro 41-5253 Ro 41-5253 results in decreased expression of SLC10A1 mRNA; Ro 41-5253 results in decreased expression of SLC10A1 protein |
CTD |
PMID:25550158 |
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NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions decreases expression |
ISO |
Ro 41-5253 inhibits the reaction [Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of STAT1 protein] Ro 41-5253 results in decreased expression of STAT1 protein |
CTD |
PMID:16007204 PMID:16085646 |
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NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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G |
Tfrc |
transferrin receptor |
multiple interactions |
EXP |
Ro 41-5253 inhibits the reaction [Tretinoin results in decreased expression of TFRC mRNA] |
CTD |
PMID:22154532 |
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NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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G |
Tnfsf11 |
TNF superfamily member 11 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]] |
CTD |
PMID:17291456 |
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NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
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