retinoic acid receptor antagonist - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	retinoic acid receptor antagonist	go back to main search page
Accession:	CHEBI:90714	browse the term
Definition:	An antagonist that acts at the retinoic acid receptor.
Synonyms:	related_synonym:	RAR antagonist; RAR antagonists; retinoic acid receptor antagonists

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Rat (43) Mouse (43) Human (43) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) All
Genes (43)

retinoic acid receptor antagonist

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Cd68 molecule

increases expression

retinoic acid receptor antagonist LE135 increases expression of CD68 protein in colonic lamina propria of DSS-induced colitis mice

RGD

NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640

O-(chloroacetylcarbamoyl)fumagillol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin D1

increases expression

O-(chloroacetylcarbamoyl)fumagillol results in increased expression of CCND1 protein

NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325

G

cyclin-dependent kinase inhibitor 1A

increases expression

O-(chloroacetylcarbamoyl)fumagillol results in increased expression of CDKN1A protein

NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864

G

fibroblast growth factor 2

multiple interactions
decreases expression

[O-(chloroacetylcarbamoyl)fumagillol co-treated with docetaxel] results in decreased expression of FGF2 protein
O-(chloroacetylcarbamoyl)fumagillol results in decreased expression of FGF2 protein

NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681

G

matrix metallopeptidase 9

multiple interactions

[O-(chloroacetylcarbamoyl)fumagillol co-treated with docetaxel] results in decreased expression of MMP9 protein

NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520

G

nuclear factor kappa B subunit 1

multiple interactions

O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]]

NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689

G

nitric oxide synthase 2

multiple interactions

O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of NOS2 protein]

NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190

G

RB transcriptional corepressor 1

decreases phosphorylation

O-(chloroacetylcarbamoyl)fumagillol results in decreased phosphorylation of RB1 protein

NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]]

NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249

G

superoxide dismutase 2

multiple interactions

O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein]

NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587

G

tumor protein p53

increases expression

O-(chloroacetylcarbamoyl)fumagillol results in increased expression of TP53 protein

NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449

Ro 41-5253

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

beta-carotene oxygenase 1

increases expression

Ro 41-5253 results in increased expression of BCO1 mRNA; Ro 41-5253 results in increased expression of BCO1 protein

NCBI chr19:49,637,059...49,673,577
Ensembl chr19:49,637,016...49,673,808

G

cyclin D3

multiple interactions

Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]]

NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943

G

cyclin E1

multiple interactions

Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCNE1 protein]]

NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980

G

CD1d1 molecule

multiple interactions

Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CD1D mRNA]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of CD1D mRNA]

NCBI chr 2:186,330,298...186,333,805
Ensembl chr 2:186,330,298...186,333,805

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDKN1B protein]]

NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964

G

cytochrome P450, family 26, subfamily a, polypeptide 1

multiple interactions

Ro 41-5253 inhibits the reaction [4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid results in increased expression of CYP26A1 mRNA]; Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CYP26A1 mRNA]

NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729

G

fatty acid binding protein 4

increases expression

Ro 41-5253 results in increased expression of FABP4 mRNA

NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305

G

ferritin heavy chain 1

multiple interactions

Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of FTH1 mRNA]

NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228

G

gap junction protein, alpha 1

multiple interactions

Ro 41-5253 inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]; Ro 41-5253 inhibits the reaction [beta Carotene results in increased expression of GJA1 protein]

NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089

G

interferon gamma

multiple interactions

Ro 41-5253 inhibits the reaction [IFNG protein promotes the reaction [Tretinoin results in increased expression of MUC4 protein]]; Ro 41-5253 inhibits the reaction [IFNG protein results in increased expression of MUC4 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of IFNG protein]

PMID:16007204 PMID:16872382

NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419

G

interferon gamma receptor 1

multiple interactions

Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IFNGR1 protein]

NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907

G

interleukin 10

multiple interactions

Ro 41-5253 inhibits the reaction [Tretinoin results in increased secretion of IL10 protein]

NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392

G

interleukin 12A

multiple interactions

Ro 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of [IL12A protein binds to IL12B protein]]

NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318

G

interleukin 12B

multiple interactions

Ro 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of [IL12A protein binds to IL12B protein]]

NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085

G

interleukin 4

multiple interactions

Ro 41-5253 inhibits the reaction [Tretinoin results in increased secretion of IL4 protein]

NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531

G

insulin 2

multiple interactions

[Dexamethasone co-treated with INS protein co-treated with Ro 41-5253] results in increased expression of PPARG protein

NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034

G

iron responsive element binding protein 2

multiple interactions

Ro 41-5253 inhibits the reaction [Tretinoin results in decreased expression of IREB2 mRNA]

NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118

G

interferon regulatory factor 1

multiple interactions

Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IRF1 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of IRF1 protein]

PMID:16085646 PMID:16636311

NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531

G

mucin 4, cell surface associated

multiple interactions

Ro 41-5253 inhibits the reaction [IFNG protein promotes the reaction [Tretinoin results in increased expression of MUC4 protein]]; Ro 41-5253 inhibits the reaction [IFNG protein results in increased expression of MUC4 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of MUC4 protein]

NCBI chr11:71,242,973...71,285,217
Ensembl chr11:71,243,334...71,284,939

G

nuclear factor of activated T-cells 1

multiple interactions

Ro 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]

NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690

G

2'-5' oligoadenylate synthetase 2

multiple interactions

Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of OAS2 mRNA]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of OAS2 mRNA]

NCBI chr12:41,341,417...41,363,124
Ensembl chr12:41,340,815...41,363,161

G

plasminogen activator, tissue type

multiple interactions

Ro 41-5253 inhibits the reaction [Retinoids results in increased expression of PLAT]

NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889

G

peroxisome proliferator-activated receptor delta

affects binding
multiple interactions

Ro 41-5253 binds to PPARD protein
Ro 41-5253 inhibits the reaction [GW 2433 binds to PPARD protein]

NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333

G

peroxisome proliferator-activated receptor gamma

multiple interactions

[Dexamethasone co-treated with INS protein co-treated with Ro 41-5253] results in increased expression of PPARG protein; Ro 41-5253 binds to and results in increased activity of PPARG protein; Ro 41-5253 inhibits the reaction [pioglitazone results in increased activity of PPARG protein]; Ro 41-5253 inhibits the reaction [rosiglitazone binds to PPARG protein]
[Dexamethasone co-treated with INS protein co-treated with Ro 41-5253] results in increased expression of PPARG protein; Ro 41-5253 results in increased activity of and results in decreased expression of PPARG protein

NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380

G

retinoic acid receptor, alpha

multiple interactions
decreases activity
increases response to substance

Am 580 inhibits the reaction [Ro 41-5253 results in decreased activity of RARA protein]; Ro 41-5253 binds to and results in decreased activity of RARA protein; Ro 41-5253 inhibits the reaction [[RARA protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of RARA mRNA]
RARA protein results in increased susceptibility to Ro 41-5253

PMID:7556191 PMID:8838863 PMID:10779427 PMID:17216566 PMID:17290005 PMID:25550158

NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210

G

retinoic acid receptor, beta

multiple interactions

Ro 41-5253 inhibits the reaction [[RARB protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]

NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599

G

retinoic acid receptor, gamma

multiple interactions

Ro 41-5253 inhibits the reaction [[RARG protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]

NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186

G

RB transcriptional corepressor 1

multiple interactions

Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RB1 protein]]

NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342

G

retinoid X receptor alpha

multiple interactions

Ro 41-5253 inhibits the reaction [[RARA protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARB protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARG protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]

NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908

G

solute carrier family 10 member 1

multiple interactions
increases response to substance
decreases expression

Ro 41-5253 inhibits the reaction [[RARA protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARB protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARG protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]
SLC10A1 protein results in increased susceptibility to Ro 41-5253
Ro 41-5253 results in decreased expression of SLC10A1 mRNA; Ro 41-5253 results in decreased expression of SLC10A1 protein

NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355

G

signal transducer and activator of transcription 1

multiple interactions
decreases expression

Ro 41-5253 inhibits the reaction [Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of STAT1 protein]
Ro 41-5253 results in decreased expression of STAT1 protein

PMID:16007204 PMID:16085646

NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533

G

transferrin receptor

multiple interactions

Ro 41-5253 inhibits the reaction [Tretinoin results in decreased expression of TFRC mRNA]

NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223

G

TNF superfamily member 11

multiple interactions

Ro 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]

NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19770
role	19720
biological role	19720
pharmacological role	18830
antagonist	16277
retinoic acid receptor antagonist	43
BMS-493	0
retinoic acid receptor alpha antagonist +	42
retinoic acid receptor gamma antagonist +	0
Path 2
Term	Annotations
CHEBI ontology	19770
role	19720
application	19411
pharmaceutical	19299
drug	19299
receptor modulator	18869
nuclear receptor modulator	7471
retinoic acid receptor modulator	7471
retinoic acid receptor antagonist	43
BMS-493	0
retinoic acid receptor alpha antagonist +	42
retinoic acid receptor gamma antagonist +	0

paths to the root