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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:retinoic acid receptor alpha antagonist
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Accession:CHEBI:90713 term browser browse the term
Definition:A retinoic acid receptor antagonist that antagonises retinoic acid receptor alpha.
Synonyms:related_synonym: RAR alpha antagonist;   RAR alpha antagonists;   RARalpha antagonist;   RARalpha antagonists;   retinoic acid receptor alpha antagonists

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O-(chloroacetylcarbamoyl)fumagillol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 increases expression ISO O-(chloroacetylcarbamoyl)fumagillol results in increased expression of CCND1 protein CTD PMID:15276080 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO O-(chloroacetylcarbamoyl)fumagillol results in increased expression of CDKN1A protein CTD PMID:15276080 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
decreases expression		 ISO [O-(chloroacetylcarbamoyl)fumagillol co-treated with docetaxel] results in decreased expression of FGF2 protein
O-(chloroacetylcarbamoyl)fumagillol results in decreased expression of FGF2 protein		 CTD PMID:12576464 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [O-(chloroacetylcarbamoyl)fumagillol co-treated with docetaxel] results in decreased expression of MMP9 protein CTD PMID:12576464 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:16061884 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of NOS2 protein] CTD PMID:16061884 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO O-(chloroacetylcarbamoyl)fumagillol results in decreased phosphorylation of RB1 protein CTD PMID:15276080 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:16061884 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP O-(chloroacetylcarbamoyl)fumagillol inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein] CTD PMID:17761372 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO O-(chloroacetylcarbamoyl)fumagillol results in increased expression of TP53 protein CTD PMID:15276080 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
Ro 41-5253 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bco1 beta-carotene oxygenase 1 increases expression ISO Ro 41-5253 results in increased expression of BCO1 mRNA; Ro 41-5253 results in increased expression of BCO1 protein CTD PMID:16186334 NCBI chr19:49,637,059...49,673,577
Ensembl chr19:49,637,016...49,673,808 		JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]] CTD PMID:17209053 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943 		JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCNE1 protein]] CTD PMID:12421932 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980 		JBrowse link
G Cd1d1 CD1d1 molecule multiple interactions ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CD1D mRNA]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of CD1D mRNA] CTD PMID:17392484 NCBI chr 2:186,330,298...186,333,805
Ensembl chr 2:186,330,298...186,333,805 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDKN1B protein]] CTD PMID:12421932 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions ISO Ro 41-5253 inhibits the reaction [4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid results in increased expression of CYP26A1 mRNA]; Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CYP26A1 mRNA] CTD PMID:10953040 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO Ro 41-5253 results in increased expression of FABP4 mRNA CTD PMID:17290005 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions EXP Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of FTH1 mRNA] CTD PMID:22154532 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO Ro 41-5253 inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]; Ro 41-5253 inhibits the reaction [beta Carotene results in increased expression of GJA1 protein] CTD PMID:16091010 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Ro 41-5253 inhibits the reaction [IFNG protein promotes the reaction [Tretinoin results in increased expression of MUC4 protein]]; Ro 41-5253 inhibits the reaction [IFNG protein results in increased expression of MUC4 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of IFNG protein] CTD PMID:16007204 PMID:16872382 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Ifngr1 interferon gamma receptor 1 multiple interactions ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IFNGR1 protein] CTD PMID:16085646 NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin results in increased secretion of IL10 protein] CTD PMID:16872382 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:16872382 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:16872382 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin results in increased secretion of IL4 protein] CTD PMID:16872382 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Dexamethasone co-treated with INS protein co-treated with Ro 41-5253] results in increased expression of PPARG protein CTD PMID:17290005 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Ireb2 iron responsive element binding protein 2 multiple interactions EXP Ro 41-5253 inhibits the reaction [Tretinoin results in decreased expression of IREB2 mRNA] CTD PMID:22154532 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118 		JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IRF1 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of IRF1 protein] CTD PMID:16085646 PMID:16636311 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531 		JBrowse link
G Muc4 mucin 4, cell surface associated multiple interactions ISO Ro 41-5253 inhibits the reaction [IFNG protein promotes the reaction [Tretinoin results in increased expression of MUC4 protein]]; Ro 41-5253 inhibits the reaction [IFNG protein results in increased expression of MUC4 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of MUC4 protein] CTD PMID:16007204 NCBI chr11:71,242,973...71,285,217
Ensembl chr11:71,243,334...71,284,939 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]] CTD PMID:17291456 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690 		JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 multiple interactions ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of OAS2 mRNA]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of OAS2 mRNA] CTD PMID:16636311 NCBI chr12:41,341,417...41,363,124
Ensembl chr12:41,340,815...41,363,161 		JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO Ro 41-5253 inhibits the reaction [Retinoids results in increased expression of PLAT] CTD PMID:7556191 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects binding
multiple interactions		 ISO Ro 41-5253 binds to PPARD protein
Ro 41-5253 inhibits the reaction [GW 2433 binds to PPARD protein]		 CTD PMID:17290005 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [Dexamethasone co-treated with INS protein co-treated with Ro 41-5253] results in increased expression of PPARG protein; Ro 41-5253 binds to and results in increased activity of PPARG protein; Ro 41-5253 inhibits the reaction [pioglitazone results in increased activity of PPARG protein]; Ro 41-5253 inhibits the reaction [rosiglitazone binds to PPARG protein]
[Dexamethasone co-treated with INS protein co-treated with Ro 41-5253] results in increased expression of PPARG protein; Ro 41-5253 results in increased activity of and results in decreased expression of PPARG protein		 CTD PMID:17290005 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions
decreases activity
increases response to substance		 ISO Am 580 inhibits the reaction [Ro 41-5253 results in decreased activity of RARA protein]; Ro 41-5253 binds to and results in decreased activity of RARA protein; Ro 41-5253 inhibits the reaction [[RARA protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of RARA mRNA]
RARA protein results in increased susceptibility to Ro 41-5253		 CTD PMID:7556191 PMID:8838863 PMID:10779427 PMID:17216566 PMID:17290005 PMID:25550158 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210 		JBrowse link
G Rarb retinoic acid receptor, beta multiple interactions ISO Ro 41-5253 inhibits the reaction [[RARB protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA] CTD PMID:25550158 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599 		JBrowse link
G Rarg retinoic acid receptor, gamma multiple interactions ISO Ro 41-5253 inhibits the reaction [[RARG protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA] CTD PMID:25550158 NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RB1 protein]] CTD PMID:12421932 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Ro 41-5253 inhibits the reaction [[RARA protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARB protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARG protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA] CTD PMID:25550158 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions
increases response to substance
decreases expression		 ISO Ro 41-5253 inhibits the reaction [[RARA protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARB protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARG protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]
SLC10A1 protein results in increased susceptibility to Ro 41-5253
Ro 41-5253 results in decreased expression of SLC10A1 mRNA; Ro 41-5253 results in decreased expression of SLC10A1 protein		 CTD PMID:25550158 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions
decreases expression		 ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of STAT1 protein]
Ro 41-5253 results in decreased expression of STAT1 protein		 CTD PMID:16007204 PMID:16085646 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Tfrc transferrin receptor multiple interactions EXP Ro 41-5253 inhibits the reaction [Tretinoin results in decreased expression of TFRC mRNA] CTD PMID:22154532 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]] CTD PMID:17291456 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      biological role 19825
        pharmacological role 18870
          antagonist 16306
            retinoic acid receptor antagonist 43
              retinoic acid receptor alpha antagonist 42
                BMS 195614 0
                BMS-453 0
                O-(chloroacetylcarbamoyl)fumagillol 10
                Ro 41-5253 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      application 19494
        pharmaceutical 19364
          drug 19364
            receptor modulator 18906
              nuclear receptor modulator 7474
                retinoic acid receptor modulator 7474
                  retinoic acid receptor antagonist 43
                    retinoic acid receptor alpha antagonist 42
                      BMS 195614 0
                      BMS-453 0
                      O-(chloroacetylcarbamoyl)fumagillol 10
                      Ro 41-5253 33
paths to the root