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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:S-methyl-L-thiocitrulline
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Accession:CHEBI:90712 term browser browse the term
Definition:An L-arginine derivative in which the guanidino NH2 group of L-arginine is replaced by a methylsufanyl group.
Synonyms:exact_synonym: N(5)-[imino(methylsulfanyl)methyl]-L-ornithine
 related_synonym: Formula=C7H15N3O2S;   InChI=1S/C7H15N3O2S/c1-13-7(9)10-4-2-3-5(8)6(11)12/h5H,2-4,8H2,1H3,(H2,9,10)(H,11,12)/t5-/m0/s1;   InChIKey=NGVMVBQRKZPFLB-YFKPBYRVSA-N;   L-S-Methylthiocitrulline;   N(delta)-(S-Methylisothioureido)norvaline;   N5-(Imino(methylthio)methyl)-L-ornithine;   S-Methylthiocitrulline;   SMILES=C(O)([C@@H](N)CCCNC(=N)SC)=O
 xref: CAS:156719-41-4
 xref_mesh: MESH:C086717
 xref: PMID:24429483;   PMID:24726981;   PMID:24961237;   PMID:25571988;   PMID:25733243;   PMID:7523410;   Reaxys:6845151


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S-methyl-L-thiocitrulline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 multiple interactions ISO S-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide] CTD PMID:16380457 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G NOS1 nitric oxide synthase 1 multiple interactions
decreases activity		 ISO [S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the susceptibility to Methamphetamine
[S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the abundance of Sodium		 CTD PMID:11006970 PMID:12511180 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170 		JBrowse link
G SLC18A2 solute carrier family 18 member A2 multiple interactions ISO S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased activity of SLC18A2 protein]; S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein] CTD PMID:17683483 NCBI chr10:117,241,114...117,279,430
Ensembl chr10:117,241,093...117,279,430 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      application 25172
        pharmaceutical 24558
          drug 24544
            protective agent 20758
              neuroprotective agent 17678
                S-methyl-L-thiocitrulline 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    main group molecular entity 25834
                      s-block molecular entity 25166
                        hydrogen molecular entity 24765
                          hydrides 22965
                            inorganic hydride 20483
                              pnictogen hydride 20424
                                nitrogen hydride 20200
                                  azane 19942
                                    ammonia 19941
                                      organic amino compound 19941
                                        amino acid 17170
                                          alpha-amino acid 14690
                                            non-proteinogenic alpha-amino acid 4512
                                              ornithine 7
                                                L-ornithine 6
                                                  L-ornithine derivative 4
                                                    S-methyl-L-thiocitrulline 3
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