Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:S-methyl-L-thiocitrulline
go back to main search page
Accession:CHEBI:90712 term browser browse the term
Definition:An L-arginine derivative in which the guanidino NH2 group of L-arginine is replaced by a methylsufanyl group.
Synonyms:exact_synonym: N(5)-[imino(methylsulfanyl)methyl]-L-ornithine
 related_synonym: Formula=C7H15N3O2S;   InChI=1S/C7H15N3O2S/c1-13-7(9)10-4-2-3-5(8)6(11)12/h5H,2-4,8H2,1H3,(H2,9,10)(H,11,12)/t5-/m0/s1;   InChIKey=NGVMVBQRKZPFLB-YFKPBYRVSA-N;   L-S-Methylthiocitrulline;   N(delta)-(S-Methylisothioureido)norvaline;   N5-(Imino(methylthio)methyl)-L-ornithine;   S-Methylthiocitrulline;   SMILES=C(O)([C@@H](N)CCCNC(=N)SC)=O
 xref: CAS:156719-41-4
 xref_mesh: MESH:C086717
 xref: PMID:24429483;   PMID:24726981;   PMID:24961237;   PMID:25571988;   PMID:25733243;   PMID:7523410;   Reaxys:6845151



show annotations for term's descendants           Sort by:
 
S-methyl-L-thiocitrulline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 multiple interactions EXP S-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide] CTD PMID:16380457 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases activity
EXP
ISO
[S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the abundance of Sodium
[S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the susceptibility to Methamphetamine
CTD PMID:11006970 PMID:12511180 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased activity of SLC18A2 protein]; S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein] CTD PMID:17683483 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      application 19747
        pharmaceutical 19619
          drug 19619
            protective agent 17994
              neuroprotective agent 15604
                S-methyl-L-thiocitrulline 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      carboxylic acid 18565
                                        amino acid 14936
                                          alpha-amino acid 12944
                                            non-proteinogenic alpha-amino acid 1760
                                              ornithine 7
                                                L-ornithine 6
                                                  L-ornithine derivative 4
                                                    S-methyl-L-thiocitrulline 3
paths to the root