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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of AKT1 protein] IC 87114 results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:16179367 PMID:19176369 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Csf2 |
colony stimulating factor 2 |
multiple interactions |
ISO |
IC 87114 inhibits the reaction [PTPN11 protein mutant form results in increased susceptibility to CSF2 protein] |
CTD |
PMID:22315502 |
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NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
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G |
Foxo3 |
forkhead box O3 |
multiple interactions decreases phosphorylation |
ISO |
IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3 protein] IC 87114 results in decreased phosphorylation of FOXO3 protein |
CTD |
PMID:16179367 |
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NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
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G |
Gsk3a |
glycogen synthase kinase 3 alpha |
decreases phosphorylation |
ISO |
IC 87114 results in decreased phosphorylation of GSK3A protein |
CTD |
PMID:16179367 |
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NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases phosphorylation |
ISO |
IC 87114 results in decreased phosphorylation of GSK3B protein |
CTD |
PMID:16179367 |
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NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of AKT1 protein]; IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3 protein]; IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK1 protein]; IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:16179367 |
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NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK1 protein] IC 87114 results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:16179367 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation |
ISO |
IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK3 protein] IC 87114 results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:16179367 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Pik3cd |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta |
decreases activity |
ISO |
IC 87114 results in decreased activity of PIK3CD protein |
CTD |
PMID:16179367 |
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NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
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G |
Ptpn11 |
protein tyrosine phosphatase, non-receptor type 11 |
multiple interactions increases response to substance |
ISO |
IC 87114 inhibits the reaction [PTPN11 protein mutant form results in increased susceptibility to CSF2 protein] PTPN11 protein mutant form results in increased susceptibility to IC 87114 |
CTD |
PMID:22315502 |
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NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases phosphorylation |
ISO |
IC 87114 results in decreased phosphorylation of RPS6KB1 protein |
CTD |
PMID:16179367 |
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NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
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