Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:SB-239063
go back to main search page
Accession:CHEBI:90681 term browser browse the term
Definition:A member of the class of imidazoles carrying 4-hydroxycyclohexyl, 4-fluorophenyl and 2-methoxypyrimidin-4-yl substituents at positions 1, 4 and 5 respectively.
Synonyms:exact_synonym: trans-4-[4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)-1H-imidazol-1-yl]cyclohexan-1-ol
 related_synonym: Formula=C20H21FN4O2;   InChI=1S/C20H21FN4O2/c1-27-20-22-11-10-17(24-20)19-18(13-2-4-14(21)5-3-13)23-12-25(19)15-6-8-16(26)9-7-15/h2-5,10-12,15-16,26H,6-9H2,1H3/t15-,16-;   InChIKey=ZQUSFAUAYSEREK-WKILWMFISA-N;   SB239063;   SMILES=C=1(N(C=NC1C=2C=CC(=CC2)F)[C@H]3CC[C@@H](CC3)O)C4=NC(OC)=NC=C4
 xref: CAS:193551-21-2
 xref_mesh: MESH:C406525
 xref: PDBeChem:SB0;   PMID:23840427;   PMID:24188200;   PMID:24307181;   Reaxys:9010076


show annotations for term's descendants           Sort by:
 
SB-239063 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp4 aquaporin 4 multiple interactions EXP SB 239063 inhibits the reaction [manganese(III) acetate dihydrate results in increased expression of AQP4 protein] CTD PMID:20648640 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO SB 239063 inhibits the reaction [perhexiline maleate results in increased expression of ATF4 protein] CTD PMID:33309543 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP SB 239063 inhibits the reaction [Particulate Matter results in decreased expression of BCL2 protein] CTD PMID:26472149 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO SB 239063 inhibits the reaction [prostaglandin E2 glyceryl ester results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:17539917 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions EXP SB 239063 inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of CYP19A1 protein] CTD PMID:20096755 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO SB 239063 inhibits the reaction [perhexiline maleate results in increased expression of DDIT3 protein] CTD PMID:33309543 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in decreased expression of DNM1L protein CTD PMID:26116440 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP SB 239063 inhibits the reaction [Smoke results in increased expression of EDNRB mRNA]; SB 239063 inhibits the reaction [Smoke results in increased expression of EDNRB protein] CTD PMID:18718921 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased phosphorylation of GSK3B protein CTD PMID:26116440 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased phosphorylation of MAPK1 protein CTD PMID:26116440 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased phosphorylation of MAPK3 protein CTD PMID:26116440 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mff mitochondrial fission factor multiple interactions EXP [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in decreased expression of MFF protein CTD PMID:26116440 NCBI chr 9:88,490,280...88,518,517
Ensembl chr 9:88,493,593...88,517,827
Ensembl chr 9:88,493,593...88,517,827
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased expression of SQSTM1 protein CTD PMID:26116440 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19770
      molecular entity 19768
        polyatomic entity 19686
          heteroatomic molecular entity 19617
            hydroxides 19077
              organic hydroxy compound 18656
                alcohol 15010
                  cyclohexanols 206
                    SB-239063 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic heterocyclic compound 18519
                                  heteroarene 16512
                                    monocyclic heteroarene 13362
                                      azole 12537
                                        diazole 8253
                                          imidazoles 7685
                                            SB-239063 13
paths to the root