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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:GSK690693
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Accession:CHEBI:90677 term browser browse the term
Definition:A member of the class of imidazopyridines that is 4-(1-ethylimidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol carrying additional 2-(4-amino-1,2,5-oxadiazol-3-yl and [(3S)-piperidin-3-yl]methoxy substituents at positions 4 and 7 respectively.
Synonyms:exact_synonym: 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-piperidin-3-yl]methoxy}-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol
 related_synonym: Formula=C21H27N7O3;   GSK 690693;   InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1;   InChIKey=KGPGFQWBCSZGEL-ZDUSSCGKSA-N;   SMILES=C=1(C(N)=NON1)C2=NC3=C(C#CC(O)(C)C)N=CC(=C3N2CC)OC[C@@H]4CNCCC4
 xref: CAS:937174-76-0
 xref_mesh: MESH:C528328
 xref: PDBeChem:G93;   PMID:18800763;   PMID:23892718;   PMID:24394624;   PMID:24715717;   PMID:25757752;   PMID:25788264;   PMID:26181325;   Reaxys:18301457


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GSK690693 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of AKT1 protein]; GSK690693 results in decreased expression of and results in increased phosphorylation of AKT1 protein
GSK690693 results in decreased phosphorylation of AKT1 protein
CTD PMID:30871965, PMID:31445927, PMID:31962201 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased expression of BCL2 protein] CTD PMID:30871965 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein] CTD PMID:30871965 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions
ISO GSK690693 results in decreased phosphorylation of EIF4EBP1 protein
[sunitinib co-treated with GSK690693] results in decreased phosphorylation of EIF4EBP1 protein
CTD PMID:22532600 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO GSK690693 affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO GSK690693 results in decreased expression of and results in decreased phosphorylation of GSK3B protein CTD PMID:31962201 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO dabrafenib inhibits the reaction [GSK690693 results in increased phosphorylation of MAPK1 protein] CTD PMID:31962201 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO GSK690693 results in increased phosphorylation of MAPK3 protein
dabrafenib inhibits the reaction [GSK690693 results in increased phosphorylation of MAPK3 protein]
CTD PMID:31962201 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in increased cleavage of PARP1 protein] CTD PMID:30871965 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Srsf4 serine and arginine rich splicing factor 4 multiple interactions ISO [SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF4 protein CTD PMID:31962201 NCBI chr 5:150,032,999...150,060,769
Ensembl chr 5:150,032,999...150,060,765
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 multiple interactions ISO [SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF5 protein CTD PMID:31962201 NCBI chr 6:104,611,026...104,640,033
Ensembl chr 6:104,611,026...104,615,302
JBrowse link
G Srsf6 serine and arginine rich splicing factor 6 multiple interactions ISO [SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF6 protein CTD PMID:31962201 NCBI chr 3:159,305,345...159,310,668
Ensembl chr 3:159,305,345...159,310,668
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein] CTD PMID:30871965 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tnf tumor necrosis factor increases response to substance ISO GSK690693 results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tsc2 TSC complex subunit 2 multiple interactions
decreases phosphorylation
ISO [sunitinib co-treated with GSK690693] results in decreased phosphorylation of TSC2 protein
GSK690693 results in decreased phosphorylation of TSC2 protein
CTD PMID:22532600 NCBI chr10:13,962,006...13,996,684
Ensembl chr10:13,961,947...13,996,584
JBrowse link

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Path 1
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  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            antineoplastic agent 16985
              GSK690693 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        primary amino compound 7860
                                          GSK690693 15
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.