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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:GSK690693
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Accession:CHEBI:90677 term browser browse the term
Definition:A member of the class of imidazopyridines that is 4-(1-ethylimidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol carrying additional 2-(4-amino-1,2,5-oxadiazol-3-yl and [(3S)-piperidin-3-yl]methoxy substituents at positions 4 and 7 respectively.
Synonyms:exact_synonym: 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-piperidin-3-yl]methoxy}-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol
 related_synonym: Formula=C21H27N7O3;   GSK 690693;   InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1;   InChIKey=KGPGFQWBCSZGEL-ZDUSSCGKSA-N;   SMILES=C=1(C(N)=NON1)C2=NC3=C(C#CC(O)(C)C)N=CC(=C3N2CC)OC[C@@H]4CNCCC4
 xref: CAS:937174-76-0
 xref_mesh: MESH:C528328
 xref: PDBeChem:G93;   PMID:18800763;   PMID:23892718;   PMID:24394624;   PMID:24715717;   PMID:25757752;   PMID:25788264;   PMID:26181325;   Reaxys:18301457



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GSK690693 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation
ISO GSK690693 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of AKT1 protein]; GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of AKT1 protein]
GSK690693 results in increased phosphorylation of AKT1 protein
GSK690693 results in decreased phosphorylation of AKT1 protein
CTD PMID:30871965 PMID:31445927 PMID:31962201 PMID:34784199 PMID:35259468 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO GSK690693 results in increased expression of BBC3 protein CTD PMID:35259468 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased expression of BCL2 protein] CTD PMID:30871965 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein] CTD PMID:30871965 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions
ISO GSK690693 results in decreased phosphorylation of EIF4EBP1 protein
[sunitinib co-treated with GSK690693] results in decreased phosphorylation of EIF4EBP1 protein
CTD PMID:22532600 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO GSK690693 affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Foxo3 forkhead box O3 decreases phosphorylation ISO GSK690693 results in decreased phosphorylation of FOXO3 protein CTD PMID:35259468 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO GSK690693 results in decreased phosphorylation of GSK3B protein CTD PMID:31962201 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO GSK690693 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein] CTD PMID:34784199 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in increased cleavage of PARP1 protein] CTD PMID:30871965 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Srsf4 serine and arginine rich splicing factor 4 multiple interactions ISO [SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF4 protein CTD PMID:31962201 NCBI chr 5:144,060,981...144,090,798
Ensembl chr 5:144,061,463...144,089,229
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 multiple interactions ISO [SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF5 protein CTD PMID:31962201 NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
JBrowse link
G Srsf6 serine and arginine rich splicing factor 6 multiple interactions ISO [SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF6 protein CTD PMID:31962201 NCBI chr 3:151,589,546...151,594,869
Ensembl chr 3:151,589,535...151,594,860
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein] CTD PMID:30871965 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor increases response to substance ISO GSK690693 results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tsc2 TSC complex subunit 2 multiple interactions
decreases phosphorylation
ISO [sunitinib co-treated with GSK690693] results in decreased phosphorylation of TSC2 protein
GSK690693 results in decreased phosphorylation of TSC2 protein
CTD PMID:22532600 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
JBrowse link

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  CHEBI ontology 19659
    role 19634
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          drug 19355
            antineoplastic agent 17598
              GSK690693 16
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  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    main group molecular entity 19649
                      s-block molecular entity 19457
                        hydrogen molecular entity 19450
                          hydrides 18928
                            inorganic hydride 17765
                              pnictogen hydride 17748
                                nitrogen hydride 17633
                                  azane 17403
                                    ammonia 17402
                                      organic amino compound 17402
                                        primary amino compound 8283
                                          GSK690693 16
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