Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:GSK690693
go back to main search page
Accession:CHEBI:90677 term browser browse the term
Definition:A member of the class of imidazopyridines that is 4-(1-ethylimidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol carrying additional 2-(4-amino-1,2,5-oxadiazol-3-yl and [(3S)-piperidin-3-yl]methoxy substituents at positions 4 and 7 respectively.
Synonyms:exact_synonym: 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-piperidin-3-yl]methoxy}-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol
 related_synonym: Formula=C21H27N7O3;   GSK 690693;   InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1;   InChIKey=KGPGFQWBCSZGEL-ZDUSSCGKSA-N;   SMILES=C=1(C(N)=NON1)C2=NC3=C(C#CC(O)(C)C)N=CC(=C3N2CC)OC[C@@H]4CNCCC4
 xref: CAS:937174-76-0
 xref_mesh: MESH:C528328
 xref: PDBeChem:G93;   PMID:18800763;   PMID:23892718;   PMID:24394624;   PMID:24715717;   PMID:25757752;   PMID:25788264;   PMID:26181325;   Reaxys:18301457


show annotations for term's descendants           Sort by:
 
GSK690693 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation
ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of AKT1 protein]
GSK690693 results in increased phosphorylation of AKT1 protein
GSK690693 results in decreased phosphorylation of AKT1 protein
CTD PMID:30871965 PMID:31445927 PMID:31962201 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased expression of BCL2 protein] CTD PMID:30871965 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein] CTD PMID:30871965 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions
ISO GSK690693 results in decreased phosphorylation of EIF4EBP1 protein
[sunitinib co-treated with GSK690693] results in decreased phosphorylation of EIF4EBP1 protein
CTD PMID:22532600 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO GSK690693 affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO GSK690693 results in decreased phosphorylation of GSK3B protein CTD PMID:31962201 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in increased cleavage of PARP1 protein] CTD PMID:30871965 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Srsf4 serine and arginine rich splicing factor 4 multiple interactions ISO [SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF4 protein CTD PMID:31962201 NCBI chr 5:144,060,981...144,090,798
Ensembl chr 5:144,061,463...144,089,229
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 multiple interactions ISO [SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF5 protein CTD PMID:31962201 NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
JBrowse link
G Srsf6 serine and arginine rich splicing factor 6 multiple interactions ISO [SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF6 protein CTD PMID:31962201 NCBI chr 3:151,589,546...151,594,869
Ensembl chr 3:151,589,535...151,594,860
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein] CTD PMID:30871965 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor increases response to substance ISO GSK690693 results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tsc2 TSC complex subunit 2 multiple interactions
decreases phosphorylation
ISO [sunitinib co-treated with GSK690693] results in decreased phosphorylation of TSC2 protein
GSK690693 results in decreased phosphorylation of TSC2 protein
CTD PMID:22532600 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            antineoplastic agent 17317
              GSK690693 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        primary amino compound 7952
                                          GSK690693 13
paths to the root