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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrimidopyridazine
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Accession:CHEBI:90614 term browser browse the term
Definition:Any organic heterobicyclic compound containing ortho-fused pyrimidine and pyridazine rings.
Synonyms:related_synonym: pyrimidopyridazines



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VX-745 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO VX-745 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:28629242 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases secretion
multiple interactions
ISO VX-745 results in decreased secretion of IL6 protein
VX-745 inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
CTD PMID:12393542 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases activity ISO VX-745 results in decreased activity of MAPK14 protein CTD PMID:28629242 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO VX-745 inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO VX-745 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; VX-745 inhibits the reaction [TNF protein results in increased secretion of IL6 protein] CTD PMID:12393542 PMID:28629242 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A decreases secretion ISO VX-745 results in decreased secretion of VEGFA protein CTD PMID:12393542 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19803
    chemical entity 19830
      atom 19801
        nonmetal atom 19739
          nitrogen atom 18931
            nitrogen molecular entity 18931
              organonitrogen compound 18806
                organonitrogen heterocyclic compound 18148
                  pyrimidopyridazine 6
                    VX-745 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19803
    subatomic particle 19801
      composite particle 19801
        hadron 19830
          baryon 19830
            nucleon 19830
              atomic nucleus 19830
                atom 19801
                  main group element atom 19780
                    p-block element atom 19780
                      p-block molecular entity 19780
                        carbon group molecular entity 19728
                          organic molecular entity 19725
                            organic molecule 19678
                              organic cyclic compound 19491
                                organic heterocyclic compound 18855
                                  organic heteropolycyclic compound 18262
                                    organic heterobicyclic compound 17228
                                      pyrimidopyridazine 6
                                        VX-745 6
paths to the root