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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:scoparone
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Accession:CHEBI:9055 term browser browse the term
Definition:A member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities.
Synonyms:exact_synonym: 6,7-dimethoxy-2H-chromen-2-one
 related_synonym: 6,7-Dimethoxycoumarin;   6,7-dimethoxy-2H-1-benzopyran-2-one;   6,7-dimethoxybenzopyran-2-one;   6,7-dimethylesculetin;   Formula=C11H10O4;   InChI=1S/C11H10O4/c1-13-9-5-7-3-4-11(12)15-8(7)6-10(9)14-2/h3-6H,1-2H3;   InChIKey=GUAFOGOEJLSQBT-UHFFFAOYSA-N;   O,O-dimethylesculetin;   O-methylisoscopoletin;   O-methylscopoletin;   SMILES=COC1=C(OC)C=C2C=CC(=O)OC2=C1;   aesculetin dimethyl ether;   escoparone;   esculetin 6,7-dimethyl ether;   esculetin dimethyl ether;   scoparon;   scopoletin methyl ether;   scopoletin monomethyl ether
 xref: CAS:120-08-1;   Chemspider:8110;   FooDB:FDB002774;   HMDB:HMDB0030818;   KEGG:C09311;   KNApSAcK:C00002498
 xref_mesh: MESH:C018145
 xref: MetaCyc:CPD-14452;   PMID:157008;   PMID:1830846;   PMID:22068685;   PMID:23086487;   PMID:23930012;   PMID:27188970;   PMID:27306123;   PMID:27869223;   PMID:27929444;   PMID:27983636;   PMID:28623783;   PMID:28950382;   PMID:28970015;   PMID:29164835;   PMID:29793313;   PMID:29901189;   PMID:29921497;   PMID:30119184;   PMID:30360359;   PMID:30736072;   PMID:30861122;   PMID:30934718;   PMID:31421545;   PMID:32000066;   PMID:32521698;   PMID:32877694;   PMID:32961278;   PMID:33090488;   PMID:33560596;   PMID:33894369;   PMID:34410946;   PMID:544448;   PMID:700833;   Reaxys:169572;   Wikipedia:Scoparone



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scoparone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased phosphorylation of AKT1 protein] CTD PMID:37436232 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Alb albumin multiple interactions ISO scoparone inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in decreased expression of ALB protein] CTD PMID:37436232 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO scoparone results in increased expression of BAX protein CTD PMID:37449671 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO scoparone results in decreased expression of BCL2 protein CTD PMID:37449671 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Casp3 caspase 3 increases cleavage ISO scoparone results in increased cleavage of CASP3 protein CTD PMID:37449671 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA]; scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of CCL2 protein]
scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of CCL2 mRNA]]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of CCL2 protein]]
CTD PMID:16376386 PMID:37436232 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Cdc42 cell division cycle 42 decreases expression ISO scoparone results in decreased expression of CDC42 mRNA CTD PMID:37449671 NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:154,839,631...154,876,627
JBrowse link
G Dct dopachrome tautomerase increases expression ISO scoparone results in increased expression of DCT mRNA CTD PMID:17049123 NCBI chr15:101,469,159...101,508,029
Ensembl chr15:101,469,159...101,508,029
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Dietary Sugars co-treated with Dietary Fats co-treated with scoparone] results in increased expression of GPT protein; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Sugars co-treated with Dietary Fats] results in increased expression of GPT protein]] CTD PMID:37436232 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO scoparone inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased expression of IFNB1 protein] CTD PMID:23535186 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased metabolism of IL1B protein] CTD PMID:37436232 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL6 protein]
scoparone inhibits the reaction [Bleomycin results in increased secretion of IL6 protein]
CTD PMID:23535186 PMID:28299617 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO scoparone inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactose] results in increased phosphorylation of IRF3 protein] CTD PMID:23535186 NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:104,616,469...104,621,401
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] affects the localization of and results in increased expression of JUN protein modified form] CTD PMID:23535186 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased phosphorylation of MAPK14 protein] CTD PMID:37436232 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO scoparone results in decreased expression of MMP2 mRNA CTD PMID:37449671 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO scoparone results in decreased expression of MMP9 mRNA
scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased expression of MMP9 protein]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of MMP9 mRNA]]
CTD PMID:37436232 PMID:37449671 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of MYD88 protein] CTD PMID:23535186 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230
JBrowse link
G Myl1 myosin, light chain 1 decreases phosphorylation ISO scoparone results in decreased phosphorylation of MYL1 protein CTD PMID:37449671 Ensembl chr 9:75,887,227...75,907,971 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO scoparone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NFKB1 protein] CTD PMID:16376386 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of NFKBIA protein] CTD PMID:16376386 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of NOS2 mRNA]] CTD PMID:37436232 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression
increases activity
ISO scoparone results in increased expression of NR1H4 mRNA
scoparone results in increased activity of NR1H4 protein
CTD PMID:36542898 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO scoparone results in increased cleavage of PARP1 protein CTD PMID:37449671 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
JBrowse link
G Pfkp phosphofructokinase, platelet decreases expression ISO scoparone results in decreased expression of PFKP mRNA CTD PMID:37449671 NCBI chr17:68,639,749...68,704,055
Ensembl chr17:68,639,481...68,705,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of PTGS2 mRNA]] CTD PMID:37436232 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO scoparone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of REL protein] CTD PMID:16376386 NCBI chr14:101,891,238...101,922,324
Ensembl chr14:101,891,243...101,921,938
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased phosphorylation of RELA protein]; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] affects the localization of and results in increased expression of RELA protein]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of RELA mRNA]]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of RELA protein]]
scoparone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of RELA protein]; scoparone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]
CTD PMID:16376386 PMID:23535186 PMID:37436232 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO scoparone results in decreased expression of RHOA mRNA; scoparone results in decreased expression of RHOA protein CTD PMID:37449671 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO scoparone results in decreased expression of ROCK1 mRNA; scoparone results in decreased expression of ROCK1 protein CTD PMID:37449671 NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,387,360...1,509,147
JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TICAM1 protein] CTD PMID:23535186 NCBI chr 9:1,189,717...1,197,730
Ensembl chr 9:1,172,963...1,196,892
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein] CTD PMID:23535186 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of TNF mRNA]]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of TNF protein]] CTD PMID:23535186 PMID:37436232 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tyr tyrosinase multiple interactions
increases expression
ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [scoparone results in increased expression of TYR protein]; scoparone results in increased expression of and results in increased activity of TYR protein
scoparone results in increased expression of TYR mRNA
CTD PMID:17049123 NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857
JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases expression ISO scoparone results in increased expression of TYRP1 mRNA CTD PMID:17049123 NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:100,327,125...100,345,657
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20841
    role 20801
      application 20602
        anti-inflammatory agent 16819
          scoparone 35
Path 2
Term Annotations click to browse term
  CHEBI ontology 20841
    subatomic particle 20839
      composite particle 20839
        hadron 20839
          baryon 20839
            nucleon 20839
              atomic nucleus 20839
                atom 20839
                  main group element atom 20762
                    p-block element atom 20786
                      carbon group element atom 20695
                        carbon atom 20690
                          organic molecular entity 20690
                            organic molecule 20634
                              organic cyclic compound 20385
                                organic heterocyclic compound 19373
                                  oxacycle 18281
                                    benzopyran 12065
                                      1-benzopyran 11812
                                        chromenes 4450
                                          chromenone 4391
                                            coumarins 4153
                                              hydroxycoumarin 358
                                                esculetin 76
                                                  scoparone 35
paths to the root