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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sclareol
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Accession:CHEBI:9053 term browser browse the term
Definition:A labdane diterpenoid that is labd-14-ene substituted by hydroxy groups at positions 8 and 13. It has been isolated from Salvia sclarea.
Synonyms:exact_synonym: (1R,2R,4aS,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-en-1-yl]-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol;   labd-14-ene-8,13-diol
 related_synonym: (13R)-Labd-14-ene-8,13-diol;   Formula=C20H36O2;   InChI=1S/C20H36O2/c1-7-18(4,21)13-9-16-19(5)12-8-11-17(2,3)15(19)10-14-20(16,6)22/h7,15-16,21-22H,1,8-14H2,2-6H3/t15-,16+,18-,19-,20+/m0/s1;   InChIKey=XVULBTBTFGYVRC-HHUCQEJWSA-N;   SMILES=[H][C@@]12CC[C@@](C)(O)[C@H](CC[C@@](C)(O)C=C)[C@@]1(C)CCCC2(C)C
 xref: Beilstein:2054148;   CAS:515-03-7;   HMDB:HMDB0036827;   KEGG:C09183;   KNApSAcK:C00000894
 xref_mesh: MESH:C070760
 xref: PMID:16527443;   PMID:22834731;   PMID:23133579;   PMID:23502334;   Reaxys:2054148;   Wikipedia:Sclareol


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sclareol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant decreases expression
multiple interactions		 ISO sclareol results in decreased expression of ACP5 mRNA; sclareol results in decreased expression of ACP5 protein
sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]		 CTD PMID:33423118 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO sclareol results in decreased phosphorylation of AKT1 protein
sclareol results in decreased expression of and results in decreased phosphorylation of AKT1 protein		 CTD PMID:33164868 PMID:33423118 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 decreases expression
multiple interactions		 ISO sclareol results in decreased expression of ATP6V0D2 mRNA
sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]		 CTD PMID:33423118 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO sclareol results in increased expression of BGLAP mRNA CTD PMID:33423118 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Ccn1 cellular communication network factor 1 increases expression
multiple interactions		 ISO sclareol results in increased expression of CCN1 mRNA; sclareol results in increased expression of CCN1 protein
[sclareol co-treated with SB 203580] results in increased expression of CCN1 protein; sclareol inhibits the reaction [TNFSF11 protein results in decreased expression of CCN1 protein]		 CTD PMID:33423118 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ctsk cathepsin K multiple interactions
decreases expression		 ISO sclareol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]
sclareol results in decreased expression of CTSK mRNA; sclareol results in decreased expression of CTSK protein		 CTD PMID:33423118 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein decreases expression
multiple interactions		 ISO sclareol results in decreased expression of DCSTAMP mRNA
sclareol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]		 CTD PMID:33423118 NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions
decreases expression		 ISO [sclareol co-treated with Cisplatin] results in decreased expression of ERCC1 protein
sclareol results in decreased expression of ERCC1 protein		 CTD PMID:33164868 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions		 ISO sclareol results in decreased expression of FOS mRNA; sclareol results in decreased expression of FOS protein
sclareol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]		 CTD PMID:33164868 PMID:33423118 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO sclareol results in decreased phosphorylation of GSK3B protein CTD PMID:33164868 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO sclareol results in decreased expression of JUN protein CTD PMID:33164868 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions		 ISO sclareol results in decreased phosphorylation of MAPK1 protein
[sclareol co-treated with TNFSF11 protein] results in decreased phosphorylation of MAPK1 protein		 CTD PMID:33423118 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions		 ISO sclareol results in decreased phosphorylation of MAPK3 protein
[sclareol co-treated with TNFSF11 protein] results in decreased phosphorylation of MAPK3 protein		 CTD PMID:33423118 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions
decreases expression		 ISO sclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]
sclareol results in decreased expression of NFATC1 mRNA; sclareol results in decreased expression of NFATC1 protein		 CTD PMID:33423118 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO sclareol results in increased expression of RUNX2 mRNA; sclareol results in increased expression of RUNX2 protein CTD PMID:33423118 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO sclareol results in decreased expression of SNAI1 protein CTD PMID:33164868 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO sclareol results in increased expression of SPP1 mRNA; sclareol results in increased expression of SPP1 protein CTD PMID:33423118 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [sclareol co-treated with TNFSF11 protein] results in decreased phosphorylation of MAPK1 protein; [sclareol co-treated with TNFSF11 protein] results in decreased phosphorylation of MAPK3 protein; sclareol inhibits the reaction [TNFSF11 protein results in decreased expression of CCN1 protein]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] CTD PMID:33423118 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    role 19724
      biological role 19722
        antimicrobial agent 17897
          sclareol 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19751
    subatomic particle 19749
      composite particle 19749
        hadron 19749
          baryon 19749
            nucleon 19749
              atomic nucleus 19749
                atom 19749
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19554
                        hydrogen molecular entity 19546
                          hydrides 19022
                            organic hydride 18635
                              organic fundamental parent 18635
                                hydrocarbon 18377
                                  terpene 13692
                                    terpenoid 13368
                                      diterpenoid 12718
                                        labdane diterpenoid 178
                                          sclareol 18
paths to the root