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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sclareol
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Accession:CHEBI:9053 term browser browse the term
Definition:A labdane diterpenoid that is labd-14-ene substituted by hydroxy groups at positions 8 and 13. It has been isolated from Salvia sclarea.
Synonyms:exact_synonym: (1R,2R,4aS,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-en-1-yl]-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol;   labd-14-ene-8,13-diol
 related_synonym: (13R)-Labd-14-ene-8,13-diol;   Formula=C20H36O2;   InChI=1S/C20H36O2/c1-7-18(4,21)13-9-16-19(5)12-8-11-17(2,3)15(19)10-14-20(16,6)22/h7,15-16,21-22H,1,8-14H2,2-6H3/t15-,16+,18-,19-,20+/m0/s1;   InChIKey=XVULBTBTFGYVRC-HHUCQEJWSA-N;   SMILES=[H][C@@]12CC[C@@](C)(O)[C@H](CC[C@@](C)(O)C=C)[C@@]1(C)CCCC2(C)C
 xref: Beilstein:2054148;   CAS:515-03-7;   HMDB:HMDB0036827;   KEGG:C09183;   KNApSAcK:C00000894
 xref_mesh: MESH:C070760
 xref: PMID:16527443;   PMID:22834731;   PMID:23133579;   PMID:23502334;   Reaxys:2054148;   Wikipedia:Sclareol


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sclareol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO sclareol results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:33164868 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions
decreases expression
ISO [sclareol co-treated with Cisplatin] results in decreased expression of ERCC1 protein
sclareol results in decreased expression of ERCC1 protein
CTD PMID:33164868 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO sclareol results in decreased expression of FOS protein CTD PMID:33164868 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO sclareol results in decreased phosphorylation of GSK3B protein CTD PMID:33164868 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO sclareol results in decreased expression of JUN protein CTD PMID:33164868 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO sclareol results in decreased expression of SNAI1 protein CTD PMID:33164868 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      biological role 19723
        antimicrobial agent 17374
          sclareol 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    main group molecular entity 19665
                      s-block molecular entity 19430
                        hydrogen molecular entity 19424
                          hydrides 18758
                            organic hydride 18356
                              organic fundamental parent 18356
                                hydrocarbon 18076
                                  terpene 12597
                                    terpenoid 12160
                                      diterpenoid 11398
                                        labdane diterpenoid 143
                                          sclareol 6
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