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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sclareol
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Accession:CHEBI:9053 term browser browse the term
Definition:A labdane diterpenoid that is labd-14-ene substituted by hydroxy groups at positions 8 and 13. It has been isolated from Salvia sclarea.
Synonyms:exact_synonym: (1R,2R,4aS,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-en-1-yl]-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol;   labd-14-ene-8,13-diol
 related_synonym: (13R)-Labd-14-ene-8,13-diol;   Formula=C20H36O2;   InChI=1S/C20H36O2/c1-7-18(4,21)13-9-16-19(5)12-8-11-17(2,3)15(19)10-14-20(16,6)22/h7,15-16,21-22H,1,8-14H2,2-6H3/t15-,16+,18-,19-,20+/m0/s1;   InChIKey=XVULBTBTFGYVRC-HHUCQEJWSA-N;   SMILES=[H][C@@]12CC[C@@](C)(O)[C@H](CC[C@@](C)(O)C=C)[C@@]1(C)CCCC2(C)C
 xref: Beilstein:2054148;   CAS:515-03-7;   HMDB:HMDB0036827;   KEGG:C09183;   KNApSAcK:C00000894
 xref_mesh: MESH:C070760
 xref: PMID:16527443;   PMID:22834731;   PMID:23133579;   PMID:23502334;   Reaxys:2054148;   Wikipedia:Sclareol



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sclareol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions
decreases expression
ISO sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]
sclareol results in decreased expression of ACP5 mRNA; sclareol results in decreased expression of ACP5 protein
CTD PMID:33423118 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO sclareol results in decreased expression of and results in decreased phosphorylation of AKT1 protein
sclareol results in decreased phosphorylation of AKT1 protein
CTD PMID:33164868 PMID:33423118 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 decreases expression
multiple interactions
ISO sclareol results in decreased expression of ATP6V0D2 mRNA
sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]
CTD PMID:33423118 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO sclareol results in increased expression of BGLAP mRNA CTD PMID:33423118 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression
multiple interactions
ISO sclareol results in increased expression of CCN1 mRNA; sclareol results in increased expression of CCN1 protein
[sclareol co-treated with SB 203580] results in increased expression of CCN1 protein; sclareol inhibits the reaction [TNFSF11 protein results in decreased expression of CCN1 protein]
CTD PMID:33423118 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ctsk cathepsin K decreases expression
multiple interactions
ISO sclareol results in decreased expression of CTSK mRNA; sclareol results in decreased expression of CTSK protein
sclareol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]
CTD PMID:33423118 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein decreases expression
multiple interactions
ISO sclareol results in decreased expression of DCSTAMP mRNA
sclareol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]
CTD PMID:33423118 NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions
decreases expression
ISO [sclareol co-treated with Cisplatin] results in decreased expression of ERCC1 protein
sclareol results in decreased expression of ERCC1 protein
CTD PMID:33164868 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
ISO sclareol results in decreased expression of FOS protein
sclareol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]
sclareol results in decreased expression of FOS mRNA; sclareol results in decreased expression of FOS protein
CTD PMID:33164868 PMID:33423118 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO sclareol results in decreased phosphorylation of GSK3B protein CTD PMID:33164868 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO sclareol results in decreased expression of JUN protein CTD PMID:33164868 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO [sclareol co-treated with TNFSF11 protein] results in decreased phosphorylation of MAPK1 protein
sclareol results in decreased phosphorylation of MAPK1 protein
CTD PMID:33423118 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO sclareol results in decreased phosphorylation of MAPK3 protein
[sclareol co-treated with TNFSF11 protein] results in decreased phosphorylation of MAPK3 protein
CTD PMID:33423118 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 decreases expression
multiple interactions
ISO sclareol results in decreased expression of NFATC1 mRNA; sclareol results in decreased expression of NFATC1 protein
sclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]
CTD PMID:33423118 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO sclareol results in increased expression of RUNX2 mRNA; sclareol results in increased expression of RUNX2 protein CTD PMID:33423118 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO sclareol results in decreased expression of SNAI1 protein CTD PMID:33164868 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO sclareol results in increased expression of SPP1 mRNA; sclareol results in increased expression of SPP1 protein CTD PMID:33423118 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [sclareol co-treated with TNFSF11 protein] results in decreased phosphorylation of MAPK1 protein; [sclareol co-treated with TNFSF11 protein] results in decreased phosphorylation of MAPK3 protein; sclareol inhibits the reaction [TNFSF11 protein results in decreased expression of CCN1 protein]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] CTD PMID:33423118 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 20059
    role 20009
      biological role 20008
        antimicrobial agent 17758
          sclareol 18
Path 2
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  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19744
                        hydrogen molecular entity 19736
                          hydrides 19102
                            organic hydride 18616
                              organic fundamental parent 18616
                                hydrocarbon 18367
                                  terpene 12740
                                    terpenoid 12309
                                      diterpenoid 11528
                                        labdane diterpenoid 152
                                          sclareol 18
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