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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:secretagogue
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Accession:CHEBI:90414 term browser browse the term
Definition:A substance that causes another substance to be secreted.
Synonyms:related_synonym: secretagogues
 xref: Wikipedia:Secretagogue



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acetohexamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Acetohexamide binds to ALB protein; Acetohexamide binds to ALB protein modified form CTD PMID:20435530 PMID:20829128 PMID:20956006 PMID:20974553 PMID:21612784 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Dhrs3 dehydrogenase/reductase (SDR family) member 3 increases metabolic processing ISO DHRS3 protein results in increased metabolism of Acetohexamide CTD PMID:25451588 NCBI chr 4:144,618,712...144,654,779
Ensembl chr 4:144,619,397...144,654,779
JBrowse link
chlorpropamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Chlorpropamide CTD PMID:22209866 NCBI chr 7:45,753,947...45,829,457
Ensembl chr 7:45,753,947...45,829,457
JBrowse link
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 decreases expression ISO Chlorpropamide results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416
JBrowse link
G Avp arginine vasopressin decreases secretion ISO Chlorpropamide results in decreased secretion of AVP protein modified form CTD PMID:5029389 NCBI chr 2:130,422,540...130,424,508
Ensembl chr 2:130,422,540...130,424,474
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO Chlorpropamide results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Ins2 insulin II decreases expression
increases expression
multiple interactions
ISO Chlorpropamide results in decreased expression of INS protein
Chlorpropamide results in increased expression of INS mRNA
Chlorpropamide inhibits the reaction [Glucose results in decreased secretion of INS protein]
CTD PMID:15642492 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Chlorpropamide CTD PMID:22209866 NCBI chr 7:45,746,547...45,750,376
Ensembl chr 7:45,743,377...45,750,188
JBrowse link
gliclazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in increased susceptibility to Gliclazide CTD PMID:22209866 NCBI chr 7:45,753,947...45,829,457
Ensembl chr 7:45,753,947...45,829,457
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 decreases activity ISO Gliclazide results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653
JBrowse link
G Alb albumin affects binding
multiple interactions
ISO Gliclazide binds to ALB protein
Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in increased secretion of ALB protein]
CTD PMID:14871415 PMID:20974553 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Gliclazide inhibits the reaction [Glucose results in decreased expression of BCL2 protein] CTD PMID:18088078 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO Gliclazide inhibits the reaction [Glucose results in increased expression of CASP3 protein]
Gliclazide results in decreased expression of CASP3 mRNA
Gliclazide inhibits the reaction [Acetic Acid results in increased expression of CASP3 protein]
CTD PMID:18088078 PMID:32045587 PMID:33652124 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cat catalase multiple interactions ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of CAT protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; Gliclazide inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:20307516 PMID:20643114 PMID:21439372 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions EXP Gliclazide inhibits the reaction [Hydrogen Peroxide results in increased expression of CDKN1A mRNA] CTD PMID:12646174 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked multiple interactions ISO Gliclazide inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:28330423 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein] CTD PMID:21439372 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GLO1 protein] CTD PMID:21439372 NCBI chr17:30,811,835...30,831,633
Ensembl chr17:30,803,910...30,845,845
JBrowse link
G Gsr glutathione reductase multiple interactions ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of GSR protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GSR protein] CTD PMID:20307516 PMID:21439372 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GSTM3 mRNA] CTD PMID:21439372 NCBI chr 3:107,803,170...107,806,001
Ensembl chr 3:107,803,137...107,806,002
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP
ISO
Gliclazide inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]
Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of HMOX1 protein]
CTD PMID:12646174 PMID:21439372 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in increased expression of ICAM1 protein]; Gliclazide inhibits the reaction [Acetic Acid results in increased expression of ICAM1 protein] CTD PMID:14871415 PMID:32045587 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in decreased expression of IL10 protein] CTD PMID:32045587 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of IL1B protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of IL1B protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of IL1B protein] CTD PMID:20307516 PMID:20643114 PMID:21439372 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of IL6 protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of IL6 protein]; Gliclazide inhibits the reaction [Acetic Acid results in increased expression of IL6 protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of IL6 protein] CTD PMID:20307516 PMID:20643114 PMID:21439372 PMID:32045587 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in increased susceptibility to Gliclazide CTD PMID:22209866 NCBI chr 7:45,746,547...45,750,376
Ensembl chr 7:45,743,377...45,750,188
JBrowse link
G Keap1 kelch-like ECH-associated protein 1 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein] CTD PMID:21439372 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in increased phosphorylation of MAPK1 protein] CTD PMID:32045587 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in increased phosphorylation of MAPK3 protein] CTD PMID:32045587 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in increased phosphorylation of MAPK8 protein] CTD PMID:32045587 NCBI chr14:33,099,855...33,169,215
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in increased activity of MPO protein] CTD PMID:32045587 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in increased expression of NCF1 protein] CTD PMID:14871415 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of NFE2L2 mRNA]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of NFE2L2 protein] CTD PMID:21439372 NCBI chr 2:75,505,857...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell increases expression ISO Gliclazide results in increased expression of NOS3 protein CTD PMID:14871415 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in decreased expression of PPARG protein] CTD PMID:32045587 NCBI chr 6:115,337,840...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of RELA protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of RELA protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of RELA protein] CTD PMID:20307516 PMID:20643114 PMID:21439372 NCBI chr19:5,687,569...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in decreased expression of SOD2 protein] CTD PMID:14871415 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of TNF protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of TNF protein]
Gliclazide results in decreased expression of TNF protein
CTD PMID:20307516 PMID:20643114 PMID:21439372 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 multiple interactions EXP Gliclazide inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFAIP3 mRNA] CTD PMID:12646174 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405
JBrowse link
G Trp53 transformation related protein 53 increases expression ISO Gliclazide results in increased expression of TP53 mRNA CTD PMID:33652124 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
glimepiride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 decreases activity
multiple interactions
ISO glimepiride results in decreased activity of ABCB11 protein
glimepiride inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:20829430 PMID:23956101 PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,960
JBrowse link
G Abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to glimepiride CTD PMID:22209866 NCBI chr 7:45,753,947...45,829,457
Ensembl chr 7:45,753,947...45,829,457
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 decreases activity ISO glimepiride results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653
JBrowse link
G Capn1 calpain 1 increases expression ISO glimepiride results in increased expression of CAPN1 mRNA CTD PMID:33652124 NCBI chr19:6,038,573...6,065,855
Ensembl chr19:6,038,573...6,065,927
JBrowse link
G Capn10 calpain 10 increases expression ISO glimepiride results in increased expression of CAPN10 mRNA CTD PMID:33652124 NCBI chr 1:92,862,130...92,875,670
Ensembl chr 1:92,862,098...92,875,663
JBrowse link
G Capn2 calpain 2 increases expression ISO glimepiride results in increased expression of CAPN2 mRNA CTD PMID:33652124 NCBI chr 1:182,294,818...182,345,175
Ensembl chr 1:182,294,825...182,345,173
JBrowse link
G Casp3 caspase 3 increases expression
increases activity
ISO glimepiride results in increased expression of CASP3 mRNA
glimepiride results in increased activity of CASP3 protein
CTD PMID:33652124 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G H2-M3 histocompatibility 2, M region locus 3 affects expression ISO glimepiride affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr17:37,581,094...37,585,376
Ensembl chr17:37,581,111...37,585,375
JBrowse link
G Ins2 insulin II decreases expression ISO glimepiride results in decreased expression of INS protein CTD PMID:15642492 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to glimepiride CTD PMID:22209866 NCBI chr 7:45,746,547...45,750,376
Ensembl chr 7:45,743,377...45,750,188
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO glimepiride results in increased activity of NR1I2 protein
[glimepiride results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:25455453 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 multiple interactions ISO glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein] CTD PMID:23121773 NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein] CTD PMID:23121773 NCBI chr 7:99,307,011...99,360,547
Ensembl chr 7:99,307,011...99,360,547
JBrowse link
G Trp53 transformation related protein 53 increases expression ISO glimepiride results in increased expression of TP53 mRNA CTD PMID:33652124 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
glipizide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 multiple interactions
decreases activity
ISO Glipizide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Glipizide results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,960
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 decreases activity ISO Glipizide results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653
JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 decreases activity ISO Glipizide results in decreased activity of AKR1C2 protein CTD PMID:26362498 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases metabolic processing
decreases metabolic processing
ISO CYP2C9 protein results in increased metabolism of Glipizide
CYP2C9 gene polymorphism results in decreased metabolism of Glipizide
CTD PMID:10208645 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 increases metabolic processing
decreases metabolic processing
ISO CYP2C9 protein results in increased metabolism of Glipizide
CYP2C9 gene polymorphism results in decreased metabolism of Glipizide
CTD PMID:10208645 NCBI chr19:39,102,342...39,175,200
Ensembl chr19:39,102,342...39,175,516
JBrowse link
tolbutamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A decreases activity
multiple interactions
ISO Tolbutamide results in decreased activity of ABCB1 protein
Tolbutamide inhibits the reaction [ABCB1 protein results in increased uptake of quinidinium]
CTD PMID:32305507 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Tolbutamide; ABCC8 gene SNP inhibits the reaction [Tolbutamide results in increased secretion of INS protein]; Tolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein] CTD PMID:9568693 PMID:18025464 PMID:22209866 NCBI chr 7:45,753,947...45,829,457
Ensembl chr 7:45,753,947...45,829,457
JBrowse link
G Alb albumin affects binding ISO Tolbutamide binds to ALB protein CTD PMID:19596536 PMID:20435530 PMID:20956006 PMID:20974553 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Tolbutamide results in increased expression of CCND1 protein CTD PMID:16718685 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccnd3 cyclin D3 increases expression ISO Tolbutamide results in increased expression of CCND3 protein CTD PMID:16718685 NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions
increases expression
ISO GJA1 promotes the reaction [Tolbutamide results in increased expression of CDKN1A protein] CTD PMID:16718685 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Tolbutamide results in increased expression of CDKN1B protein CTD PMID:16718685 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
JBrowse link
G Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 increases metabolic processing
multiple interactions
EXP CYP2C23 protein results in increased metabolism of Tolbutamide
[CYP2C23 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CTD PMID:30503582 NCBI chr19:43,993,461...44,017,695
Ensembl chr19:43,993,461...44,017,647
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases hydroxylation ISO CYP2C8 protein results in increased hydroxylation of Tolbutamide CTD PMID:15843491 NCBI chr19:39,275,488...39,319,157
Ensembl chr19:39,257,849...39,319,157
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 increases metabolic processing
multiple interactions
increases hydroxylation
ISO CYP2C19 protein results in increased metabolism of Tolbutamide
[CYP2C19 protein results in increased hydroxylation of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CTD PMID:18511451 PMID:30500380 NCBI chr19:39,378,000...39,451,547
Ensembl chr19:39,378,000...39,451,519
JBrowse link
G Cyp2c39 cytochrome P450, family 2, subfamily c, polypeptide 39 multiple interactions
increases metabolic processing
EXP [CYP2C39 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide CTD PMID:30503582 NCBI chr19:39,335,790...39,558,012
Ensembl chr19:39,499,306...39,556,973
JBrowse link
G Cyp2c40 cytochrome P450, family 2, subfamily c, polypeptide 40 increases metabolic processing
multiple interactions
EXP CYP2C40 protein results in increased metabolism of Tolbutamide
[CYP2C40 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CTD PMID:30503582 NCBI chr19:39,755,517...39,801,258
Ensembl chr19:39,755,515...39,801,258
JBrowse link
G Cyp2c50 cytochrome P450, family 2, subfamily c, polypeptide 50 increases metabolic processing
multiple interactions
EXP CYP2C50 protein results in increased metabolism of Tolbutamide
[CYP2C50 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CTD PMID:30503582 NCBI chr19:40,078,123...40,102,399
Ensembl chr19:40,078,132...40,102,394
JBrowse link
G Cyp2c54 cytochrome P450, family 2, subfamily c, polypeptide 54 increases metabolic processing
multiple interactions
EXP CYP2C54 protein results in increased metabolism of Tolbutamide
[CYP2C54 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CTD PMID:30503582 NCBI chr19:40,026,383...40,062,289
Ensembl chr19:40,026,384...40,062,271
JBrowse link
G Cyp2c55 cytochrome P450, family 2, subfamily c, polypeptide 55 increases metabolic processing
multiple interactions
ISO
EXP
CYP2C18 results in increased metabolism of Tolbutamide
CYP2C55 protein results in increased metabolism of Tolbutamide
[CYP2C55 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CTD PMID:15301741 PMID:30503582 NCBI chr19:38,995,384...39,031,134
Ensembl chr19:38,995,463...39,031,137
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 decreases hydroxylation
increases metabolic processing
multiple interactions
increases hydroxylation
increases hydrolysis
affects hydroxylation
affects metabolic processing
decreases metabolic processing
increases chemical synthesis
ISO
EXP
CYP2C9 gene SNP results in decreased hydroxylation of Tolbutamide
CYP2C65 protein results in increased metabolism of Tolbutamide
[CYP2C65 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CYP2C9 protein results in increased hydroxylation of Tolbutamide
[CYP2C9 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide; Acetone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; acetonitrile promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; CYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; CYP2C9 protein binds to and affects the metabolism of Tolbutamide; Fenitrothion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; Malathion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; phenthoate inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; pranlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; profenofos inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased hydrolysis of Tolbutamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; Ticlopidine inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; Tolbutamide inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; zafirlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]
CYP2C9 protein affects the hydroxylation of Tolbutamide
CYP2C9 gene polymorphism affects the metabolism of Tolbutamide; CYP2C9 gene SNP affects the metabolism of Tolbutamide; CYP2C9 protein affects the metabolism of Tolbutamide
CYP2C9 gene polymorphism results in decreased metabolism of Tolbutamide
CYP2C9 protein results in increased chemical synthesis of Tolbutamide metabolite
CTD PMID:2025243 PMID:9110362 PMID:9170147 PMID:9522436 PMID:10208645 More... NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 decreases hydroxylation
increases metabolic processing
multiple interactions
increases hydroxylation
increases hydrolysis
affects hydroxylation
affects metabolic processing
decreases metabolic processing
increases chemical synthesis
ISO
EXP
CYP2C9 gene SNP results in decreased hydroxylation of Tolbutamide
CYP2C66 protein results in increased metabolism of Tolbutamide
[CYP2C66 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CYP2C9 protein results in increased hydroxylation of Tolbutamide
CYP2C9 protein results in increased metabolism of Tolbutamide
CYP2C9 protein results in increased hydrolysis of Tolbutamide
CYP2C9 protein affects the hydroxylation of Tolbutamide
CYP2C9 gene polymorphism affects the metabolism of Tolbutamide; CYP2C9 gene SNP affects the metabolism of Tolbutamide; CYP2C9 protein affects the metabolism of Tolbutamide
[CYP2C9 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide; Acetone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; acetonitrile promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; CYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; CYP2C9 protein binds to and affects the metabolism of Tolbutamide; Fenitrothion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; Malathion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; phenthoate inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; pranlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; profenofos inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased hydrolysis of Tolbutamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; Ticlopidine inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; Tolbutamide inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; zafirlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]
CYP2C9 gene polymorphism results in decreased metabolism of Tolbutamide
CYP2C9 protein results in increased chemical synthesis of Tolbutamide metabolite
CTD PMID:2025243 PMID:9110362 PMID:9170147 PMID:9522436 PMID:10208645 More... NCBI chr19:39,102,342...39,175,200
Ensembl chr19:39,102,342...39,175,516
JBrowse link
G Cyp2c67 cytochrome P450, family 2, subfamily c, polypeptide 67 increases metabolic processing
multiple interactions
EXP CYP2C67 protein results in increased metabolism of Tolbutamide
[CYP2C67 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CTD PMID:30503582 NCBI chr19:39,597,288...39,637,523
Ensembl chr19:39,597,286...39,637,495
JBrowse link
G Cyp2c68 cytochrome P450, family 2, subfamily c, polypeptide 68 multiple interactions
increases metabolic processing
EXP [CYP2C68 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide CTD PMID:30503582 NCBI chr19:39,677,280...39,729,545
Ensembl chr19:39,677,278...39,729,498
JBrowse link
G Cyp2c69 cytochrome P450, family 2, subfamily c, polypeptide 69 multiple interactions
increases metabolic processing
EXP [CYP2C69 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide CTD PMID:30503582 NCBI chr19:39,831,104...39,875,213
Ensembl chr19:39,831,258...39,875,243
JBrowse link
G Cyp2c70 cytochrome P450, family 2, subfamily c, polypeptide 70 increases metabolic processing
multiple interactions
EXP CYP2C70 protein results in increased metabolism of Tolbutamide
[CYP2C70 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CTD PMID:30503582 NCBI chr19:40,141,805...40,175,730
Ensembl chr19:40,141,797...40,175,777
JBrowse link
G Gcg glucagon increases secretion ISO Tolbutamide results in increased secretion of GCG protein CTD PMID:15919803 NCBI chr 2:62,304,874...62,313,997
Ensembl chr 2:62,304,874...62,313,994
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases expression
ISO GJA1 promotes the reaction [Tolbutamide results in increased expression of CDKN1A protein]; Tolbutamide promotes the reaction [Bucladesine results in increased expression of GJA1 protein]
Tolbutamide results in increased expression of GJA1 protein
CTD PMID:11741589 PMID:16718685 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
JBrowse link
G Hk1 hexokinase 1 increases expression EXP Tolbutamide results in increased expression of HK1 protein CTD PMID:11835228 NCBI chr10:62,104,634...62,215,699
Ensembl chr10:62,104,634...62,215,687
JBrowse link
G Ins1 insulin I affects secretion
multiple interactions
EXP Tolbutamide affects the secretion of INS1 protein
Tolbutamide inhibits the reaction [arsenite inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Tolbutamide inhibits the reaction [dimethylarsinous acid inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Tolbutamide inhibits the reaction [methylarsonite inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Tolbutamide promotes the reaction [Glucose results in increased secretion of INS1 protein]
CTD PMID:9366569 PMID:31332465 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Ins2 insulin II multiple interactions
increases secretion
ISO ABCC8 gene SNP inhibits the reaction [Tolbutamide results in increased secretion of INS protein] CTD PMID:9032110 PMID:9568693 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 multiple interactions
decreases activity
ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Tolbutamide; Tolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein]
Tolbutamide results in decreased activity of KCNJ11 protein
CTD PMID:18025464 PMID:22209866 NCBI chr 7:45,746,547...45,750,376
Ensembl chr 7:45,743,377...45,750,188
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 decreases expression ISO Tolbutamide results in decreased expression of MKI67 protein CTD PMID:16718685 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
JBrowse link
G Pdcd4 programmed cell death 4 decreases expression
increases expression
ISO Tolbutamide results in decreased expression of PDCD4 mRNA
Tolbutamide results in increased expression of PDCD4 mRNA
CTD PMID:21873647 NCBI chr19:53,880,662...53,926,024
Ensembl chr19:53,880,662...53,918,291
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Tolbutamide results in decreased phosphorylation of RB1 protein CTD PMID:16718685 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 increases expression EXP Tolbutamide results in increased expression of SLC2A1 mRNA; Tolbutamide results in increased expression of SLC2A1 protein CTD PMID:2682625 PMID:11835228 NCBI chr 4:118,965,942...118,994,527
Ensembl chr 4:118,965,908...118,995,180
JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 decreases expression ISO Tolbutamide results in decreased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405
JBrowse link
G Tpd52 tumor protein D52 decreases expression
increases expression
ISO Tolbutamide results in decreased expression of TPD52 mRNA
Tolbutamide results in increased expression of TPD52 mRNA
CTD PMID:21873647 NCBI chr 3:8,991,590...9,069,824
Ensembl chr 3:8,990,653...9,069,783
JBrowse link
G Trp53 transformation related protein 53 increases expression ISO Tolbutamide results in increased expression of TP53 mRNA CTD PMID:16426753 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Ugdh UDP-glucose dehydrogenase decreases expression ISO Tolbutamide results in decreased expression of UGDH protein CTD PMID:4270849 NCBI chr 5:65,570,550...65,593,185
Ensembl chr 5:65,570,564...65,593,292
JBrowse link

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  CHEBI ontology 21863
    role 21844
      biological role 21842
        biochemical role 21102
          secretagogue 74
            insulin secretagogue + 74
paths to the root