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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:homocysteic acid
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Accession:CHEBI:90324 term browser browse the term
Definition:A non-proteinogenic alpha-amino acid that is homocysteine in which the thiol group has benn oxidised to the corresponding sulfonic acid.
Synonyms:exact_synonym: 2-amino-4-sulfobutanoic acid
 related_synonym: 2-Amino-4-sulfobutyric acid;   Formula=C4H9NO5S;   InChI=1S/C4H9NO5S/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H,8,9,10);   InChIKey=VBOQYPQEPHKASR-UHFFFAOYSA-N;   SMILES=OC(C(CCS(O)(=O)=O)N)=O
 xref: CAS:1001-13-4
 xref_mesh: MESH:C007956
 xref: PMID:26335909;   PMID:27225950;   Reaxys:1783391


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homocysteic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP [homocysteic acid co-treated with GW 506033X] results in increased phosphorylation of EIF2S1 protein CTD PMID:19046382 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Hsf1 heat shock transcription factor 1 decreases expression EXP homocysteic acid results in decreased expression of HSF1 protein CTD PMID:24478344 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Sp1 Sp1 transcription factor increases activity
multiple interactions
ISO homocysteic acid results in increased activity of SP1 protein
mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP1 protein]
CTD PMID:11261509 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sp3 Sp3 transcription factor multiple interactions
increases activity
ISO mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP3 protein] CTD PMID:11261509 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            fundamental metabolite 12766
              homocysteine 133
                homocysteic acid 4
                  D-homocysteic acid + 0
                  L-homocysteic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        amino acid 14879
                                          alpha-amino acid 12854
                                            non-proteinogenic alpha-amino acid 1740
                                              homocysteines 407
                                                homocysteine 133
                                                  homocysteic acid 4
                                                    D-homocysteic acid + 0
                                                    L-homocysteic acid + 0
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