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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:PLX-4720
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Accession:CHEBI:90295 term browser browse the term
Definition:A pyrrolopyridine that is vemurafenib in which the p-chlorophenyl group has been replaced by chlorine. It is a potent and selective inhibitor of the Raf kinase B-Raf(V600E).
Synonyms:exact_synonym: N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide
 related_synonym: Formula=C17H14ClF2N3O3S;   InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22);   InChIKey=YZDJQTHVDDOVHR-UHFFFAOYSA-N;   N-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide;   PLX4720;   SMILES=C(CC)S(NC1=CC=C(C(=C1F)C(C=2C3=C(N=CC(=C3)Cl)NC2)=O)F)(=O)=O
 xref: CAS:918505-84-7;   LINCS:LSM-1049
 xref_mesh: MESH:C528407
 xref: PDBeChem:324;   PMID:20818433;   PMID:21088259;   PMID:21134546;   PMID:21355020;   PMID:21738740;   PMID:22858545;   PMID:22941213;   PMID:24735766;   PMID:25544599;   PMID:26347528;   PMID:26456124;   Reaxys:12833018


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PLX-4720 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSF1 heat shock transcription factor 1 decreases activity EXP PLX 4720 results in decreased activity of HSF1 protein CTD PMID:34170685 NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      application 25179
        pharmaceutical 24553
          drug 24550
            antineoplastic agent 20858
              PLX-4720 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      chalcogen 24924
                        oxygen atom 24814
                          oxygen molecular entity 24814
                            hydroxides 24056
                              oxoacid 22984
                                chalcogen oxoacid 14522
                                  sulfur oxoacid 14271
                                    sulfonic acid 11978
                                      sulfonic acid derivative 11978
                                        sulfonamide 5312
                                          PLX-4720 1
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