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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N(1),N(12)-diethylspermine
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Accession:CHEBI:90282 term browser browse the term
Definition:A substituted spermine that is spermine in which a hydrogen attached to each of the primary amino groups has been replaced by an ethyl group.
Synonyms:exact_synonym: N,N'-bis[3-(ethylamino)propyl]butane-1,4-diamine
 related_synonym: 1,12-Besm;   Be-3-4-3;   Formula=C14H34N4;   InChI=1S/C14H34N4/c1-3-15-11-7-13-17-9-5-6-10-18-14-8-12-16-4-2/h15-18H,3-14H2,1-2H3;   InChIKey=PGMIWVSHZMWSSI-UHFFFAOYSA-N;   N(1),N(12)-bis(ethyl)spermine;   N1,N12-bis(ethyl)spermine;   SMILES=N(CCCNCC)CCCCNCCCNCC
 xref: CAS:61345-84-4
 xref_mesh: MESH:C052614
 xref: PMID:11313919;   PMID:11485561;   PMID:12737625;   PMID:7577929;   PMID:9115288;   Reaxys:6475489


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N(1),N(12)-diethylspermine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sat1 spermidine/spermine N1-acetyl transferase 1 multiple interactions
increases expression
ISO [N(1), N(12)-diethylspermine co-treated with Fluorouracil] results in increased activity of SAT1 protein; [N(1), N(12)-diethylspermine co-treated with stallimycin] results in increased activity of SAT1 protein; stallimycin promotes the reaction [N(1), N(12)-diethylspermine results in increased expression of SAT1 protein] CTD PMID:21814787 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765
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Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      chemical role 19248
        antioxidant 14209
          spermine 66
            substituted spermine 1
              N(1),N(12)-diethylspermine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        polyamine 8104
                                          tetramine 184
                                            spermine 66
                                              substituted spermine 1
                                                N(1),N(12)-diethylspermine 1
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