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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:90282 term browser browse the term
Definition:A substituted spermine that is spermine in which a hydrogen attached to each of the primary amino groups has been replaced by an ethyl group.
Synonyms:exact_synonym: N,N'-bis[3-(ethylamino)propyl]butane-1,4-diamine
 related_synonym: 1,12-Besm;   Be-3-4-3;   Formula=C14H34N4;   InChI=1S/C14H34N4/c1-3-15-11-7-13-17-9-5-6-10-18-14-8-12-16-4-2/h15-18H,3-14H2,1-2H3;   InChIKey=PGMIWVSHZMWSSI-UHFFFAOYSA-N;   N(1),N(12)-bis(ethyl)spermine;   N1,N12-bis(ethyl)spermine;   SMILES=N(CCCNCC)CCCCNCCCNCC
 xref: CAS:61345-84-4
 xref_mesh: MESH:C052614
 xref: PMID:11313919;   PMID:11485561;   PMID:12737625;   PMID:7577929;   PMID:9115288;   Reaxys:6475489

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N(1),N(12)-diethylspermine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sat1 spermidine/spermine N1-acetyl transferase 1 multiple interactions
increases expression
ISO [N(1), N(12)-diethylspermine co-treated with Fluorouracil] results in increased activity of SAT1 protein; [N(1), N(12)-diethylspermine co-treated with stallimycin] results in increased activity of SAT1 protein; stallimycin promotes the reaction [N(1), N(12)-diethylspermine results in increased expression of SAT1 protein] CTD PMID:21814787 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      chemical role 19589
        antioxidant 15678
          spermine 66
            substituted spermine 1
              N(1),N(12)-diethylspermine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    main group molecular entity 19960
                      s-block molecular entity 19784
                        hydrogen molecular entity 19777
                          hydrides 19115
                            inorganic hydride 17901
                              pnictogen hydride 17884
                                nitrogen hydride 17773
                                  azane 17503
                                    ammonia 17521
                                      organic amino compound 17521
                                        polyamine 8322
                                          tetramine 185
                                            spermine 66
                                              substituted spermine 1
                                                N(1),N(12)-diethylspermine 1
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