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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N(1),N(12)-diethylspermine
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Accession:CHEBI:90282 term browser browse the term
Definition:A substituted spermine that is spermine in which a hydrogen attached to each of the primary amino groups has been replaced by an ethyl group.
Synonyms:exact_synonym: N,N'-bis[3-(ethylamino)propyl]butane-1,4-diamine
 related_synonym: 1,12-Besm;   Be-3-4-3;   Formula=C14H34N4;   InChI=1S/C14H34N4/c1-3-15-11-7-13-17-9-5-6-10-18-14-8-12-16-4-2/h15-18H,3-14H2,1-2H3;   InChIKey=PGMIWVSHZMWSSI-UHFFFAOYSA-N;   N(1),N(12)-bis(ethyl)spermine;   N1,N12-bis(ethyl)spermine;   SMILES=N(CCCNCC)CCCCNCCCNCC
 xref: CAS:61345-84-4
 xref_mesh: MESH:C052614
 xref: PMID:11313919;   PMID:11485561;   PMID:12737625;   PMID:7577929;   PMID:9115288;   Reaxys:6475489


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N(1),N(12)-diethylspermine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sat1 spermidine/spermine N1-acetyl transferase 1 multiple interactions
increases expression
ISO [N(1), N(12)-diethylspermine co-treated with Fluorouracil] results in increased activity of SAT1 protein; [N(1), N(12)-diethylspermine co-treated with stallimycin] results in increased activity of SAT1 protein; stallimycin promotes the reaction [N(1), N(12)-diethylspermine results in increased expression of SAT1 protein] CTD PMID:21814787 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813
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  CHEBI ontology 19821
    role 19769
      chemical role 19345
        antioxidant 14443
          spermine 65
            substituted spermine 1
              N(1),N(12)-diethylspermine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        polyamine 8267
                                          tetramine 184
                                            spermine 65
                                              substituted spermine 1
                                                N(1),N(12)-diethylspermine 1
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