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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tiazofurine
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Accession:CHEBI:90239 term browser browse the term
Definition:A C-glycosyl compound that is 1,3-thiazole-4-carboxamide in which the hydrogen at position 2 has been replaced by a beta-D-ribofuranosyl group. It is metabolised to thiazole-4-carboxamide adenine dinucleotide (TAD), a selective inhibitor of inosine monophosphate dehydrogenase (IMP dehydrogenase).
Synonyms:exact_synonym: (1R)-1,4-anhydro-1-(4-carbamoyl-1,3-thiazol-2-yl)-D-ribitol
 related_synonym: 2-beta-D-ribofuranosyl-4-thiazolecarboxamide;   CI-909;   Formula=C9H12N2O5S;   InChI=1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1;   InChIKey=FVRDYQYEVDDKCR-DBRKOABJSA-N;   SMILES=O1[C@@H](C=2SC=C(N2)C(N)=O)[C@H](O)[C@H](O)[C@H]1CO;   TCAR;   riboxamide;   tiazofurin;   tiazofurina;   tiazofurinum
 xref: CAS:60084-10-8;   KEGG:D06130
 xref_mesh: MESH:C033706
 xref: PDBeChem:TIZ;   PMID:11249583;   PMID:23764899;   PMID:2712550;   PMID:8667040;   Reaxys:1084555;   Wikipedia:Tiazofurin



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tiazofurine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kras KRAS proto-oncogene, GTPase multiple interactions
decreases expression
ISO Guanosine inhibits the reaction [tiazofurin results in decreased expression of KRAS] CTD PMID:9381980 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions
ISO tiazofurin results in decreased expression of MYC
Guanosine inhibits the reaction [tiazofurin results in decreased expression of MYC]
CTD PMID:9381980 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link

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  CHEBI ontology 19860
    role 19832
      application 19675
        pro-agent 11550
          prodrug 11310
            tiazofurine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19860
    subatomic particle 19858
      composite particle 19858
        hadron 19858
          baryon 19858
            nucleon 19858
              atomic nucleus 19858
                atom 19858
                  main group element atom 19804
                    p-block element atom 19804
                      carbon group element atom 19745
                        carbon atom 19741
                          organic molecular entity 19741
                            heteroorganic entity 19494
                              organochalcogen compound 19257
                                organooxygen compound 19173
                                  carbohydrates and carbohydrate derivatives 15291
                                    carbohydrate 15291
                                      monosaccharide 4811
                                        aldose 3227
                                          aldopentose 762
                                            ribose 760
                                              D-ribose 758
                                                D-ribofuranose 758
                                                  beta-D-ribose 408
                                                    tiazofurine 2
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