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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tiazofurine
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Accession:CHEBI:90239 term browser browse the term
Definition:A C-glycosyl compound that is 1,3-thiazole-4-carboxamide in which the hydrogen at position 2 has been replaced by a beta-D-ribofuranosyl group. It is metabolised to thiazole-4-carboxamide adenine dinucleotide (TAD), a selective inhibitor of inosine monophosphate dehydrogenase (IMP dehydrogenase).
Synonyms:exact_synonym: (1R)-1,4-anhydro-1-(4-carbamoyl-1,3-thiazol-2-yl)-D-ribitol
 related_synonym: 2-beta-D-ribofuranosyl-4-thiazolecarboxamide;   CI-909;   Formula=C9H12N2O5S;   InChI=1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1;   InChIKey=FVRDYQYEVDDKCR-DBRKOABJSA-N;   SMILES=O1[C@@H](C=2SC=C(N2)C(N)=O)[C@H](O)[C@H](O)[C@H]1CO;   TCAR;   riboxamide;   tiazofurin;   tiazofurina;   tiazofurinum
 xref: CAS:60084-10-8;   KEGG:D06130
 xref_mesh: MESH:C033706
 xref: PDBeChem:TIZ;   PMID:11249583;   PMID:23764899;   PMID:2712550;   PMID:8667040;   Reaxys:1084555;   Wikipedia:Tiazofurin



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tiazofurine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kras KRAS proto-oncogene, GTPase multiple interactions
decreases expression
ISO Guanosine inhibits the reaction [tiazofurin results in decreased expression of KRAS] CTD PMID:9381980 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions
ISO tiazofurin results in decreased expression of MYC
Guanosine inhibits the reaction [tiazofurin results in decreased expression of MYC]
CTD PMID:9381980 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link

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  CHEBI ontology 19808
    role 19757
      application 19467
        pro-agent 10095
          prodrug 9899
            tiazofurine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            heteroorganic entity 19280
                              organochalcogen compound 19051
                                organooxygen compound 19001
                                  carbohydrates and carbohydrate derivatives 12344
                                    carbohydrate 12344
                                      monosaccharide 4297
                                        aldose 2673
                                          aldopentose 699
                                            ribose 697
                                              D-ribose 696
                                                D-ribofuranose 696
                                                  beta-D-ribose 392
                                                    tiazofurine 2
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