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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tiazofurine
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Accession:CHEBI:90239 term browser browse the term
Definition:A C-glycosyl compound that is 1,3-thiazole-4-carboxamide in which the hydrogen at position 2 has been replaced by a beta-D-ribofuranosyl group. It is metabolised to thiazole-4-carboxamide adenine dinucleotide (TAD), a selective inhibitor of inosine monophosphate dehydrogenase (IMP dehydrogenase).
Synonyms:exact_synonym: (1R)-1,4-anhydro-1-(4-carbamoyl-1,3-thiazol-2-yl)-D-ribitol
 related_synonym: 2-beta-D-ribofuranosyl-4-thiazolecarboxamide;   CI-909;   Formula=C9H12N2O5S;   InChI=1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1;   InChIKey=FVRDYQYEVDDKCR-DBRKOABJSA-N;   SMILES=O1[C@@H](C=2SC=C(N2)C(N)=O)[C@H](O)[C@H](O)[C@H]1CO;   TCAR;   riboxamide;   tiazofurin;   tiazofurina;   tiazofurinum
 xref: CAS:60084-10-8;   KEGG:D06130
 xref_mesh: MESH:C033706
 xref: PDBeChem:TIZ;   PMID:11249583;   PMID:23764899;   PMID:2712550;   PMID:8667040;   Reaxys:1084555;   Wikipedia:Tiazofurin


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tiazofurine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kras KRAS proto-oncogene, GTPase multiple interactions
decreases expression
ISO Guanosine inhibits the reaction [tiazofurin results in decreased expression of KRAS] CTD PMID:9381980 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions
ISO tiazofurin results in decreased expression of MYC
Guanosine inhibits the reaction [tiazofurin results in decreased expression of MYC]
CTD PMID:9381980 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pro-agent 8830
          prodrug 8610
            tiazofurine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            heteroorganic entity 19148
                              organochalcogen compound 18856
                                organooxygen compound 18778
                                  carbohydrates and carbohydrate derivatives 12180
                                    carbohydrate 12180
                                      monosaccharide 4023
                                        aldose 2537
                                          aldopentose 672
                                            ribose 670
                                              D-ribose 668
                                                D-ribofuranose 668
                                                  beta-D-ribose 387
                                                    tiazofurine 2
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