CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: spiruchostatin B
Accession: CHEBI:90235
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Definition: A spiruchostatin with molecular formula C21H33N3O6S2 originally isolated from a Pseudomonas culture broth.
Synonyms: exact_synonym: (1S,5S,6R,9S,15E,20R)-6-[(2S)-butan-2-yl]-5-hydroxy-20-methyl-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetrone
related_synonym: Formula=C21H33N3O6S2; InChI=1S/C21H33N3O6S2/c1-4-12(2)19-16(25)10-18(27)30-14-7-5-6-8-31-32-11-15(21(29)24-19)23-20(28)13(3)22-17(26)9-14/h5,7,12-16,19,25H,4,6,8-11H2,1-3H3,(H,22,26)(H,23,28)(H,24,29)/b7-5+/t12-,13+,14+,15+,16-,19+/m0/s1; InChIKey=MJHZJODQLYCXHE-WXZCCWHXSA-N; SMILES=C1SSCCC=C[C@@H]2CC(N[C@@](C(N[C@H]1C(N[C@@]([C@H](CC(O2)=O)O)([C@H](CC)C)[H])=O)=O)(C)[H])=O
xref_mesh: MESH:C529984
xref: PMID:18368162; PMID:19333864; PMID:19760730; PMID:21445425; PMID:22211246; PMID:25078973; Reaxys:18598407
G
Bid
BH3 interacting domain death agonist
increases activity
ISO
spiruchostatin B results in increased activity of BID protein
CTD
PMID:25078973
NCBI chr 4:155,785,366...155,808,775
G
Casp3
caspase 3
increases activity
ISO
spiruchostatin B results in increased activity of CASP3 protein
CTD
PMID:25078973
NCBI chr16:52,395,539...52,413,794
G
Casp8
caspase 8
increases activity
ISO
spiruchostatin B results in increased activity of CASP8 protein
CTD
PMID:25078973
NCBI chr 9:67,747,109...67,806,699
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