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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:spiruchostatin B
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Accession:CHEBI:90235 term browser browse the term
Definition:A spiruchostatin with molecular formula C21H33N3O6S2 originally isolated from a Pseudomonas culture broth.
Synonyms:exact_synonym: (1S,5S,6R,9S,15E,20R)-6-[(2S)-butan-2-yl]-5-hydroxy-20-methyl-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetrone
 related_synonym: Formula=C21H33N3O6S2;   InChI=1S/C21H33N3O6S2/c1-4-12(2)19-16(25)10-18(27)30-14-7-5-6-8-31-32-11-15(21(29)24-19)23-20(28)13(3)22-17(26)9-14/h5,7,12-16,19,25H,4,6,8-11H2,1-3H3,(H,22,26)(H,23,28)(H,24,29)/b7-5+/t12-,13+,14+,15+,16-,19+/m0/s1;   InChIKey=MJHZJODQLYCXHE-WXZCCWHXSA-N;   SMILES=C1SSCCC=C[C@@H]2CC(N[C@@](C(N[C@H]1C(N[C@@]([C@H](CC(O2)=O)O)([C@H](CC)C)[H])=O)=O)(C)[H])=O
 xref_mesh: MESH:C529984
 xref: PMID:18368162;   PMID:19333864;   PMID:19760730;   PMID:21445425;   PMID:22211246;   PMID:25078973;   Reaxys:18598407



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spiruchostatin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist increases activity ISO spiruchostatin B results in increased activity of BID protein CTD PMID:25078973 NCBI chr 4:155,785,366...155,808,775 JBrowse link
G Casp3 caspase 3 increases activity ISO spiruchostatin B results in increased activity of CASP3 protein CTD PMID:25078973 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp8 caspase 8 increases activity ISO spiruchostatin B results in increased activity of CASP8 protein CTD PMID:25078973 NCBI chr 9:67,747,109...67,806,699 JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      application 19715
        pharmaceutical 19551
          drug 19551
            antineoplastic agent 17840
              spiruchostatin B 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organochalcogen compound 19296
                                organooxygen compound 19213
                                  carbon oxoacid 18682
                                    carboxylic acid 18679
                                      carboacyl group 17726
                                        univalent carboacyl group 17726
                                          carbamoyl group 17570
                                            carboxamide 17570
                                              peptide 11451
                                                depsipeptide 4573
                                                  cyclodepsipeptide 4561
                                                    spiruchostatin 3
                                                      spiruchostatin B 3
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