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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:spiruchostatin B
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Accession:CHEBI:90235 term browser browse the term
Definition:A spiruchostatin with molecular formula C21H33N3O6S2 originally isolated from a Pseudomonas culture broth.
Synonyms:exact_synonym: (1S,5S,6R,9S,15E,20R)-6-[(2S)-butan-2-yl]-5-hydroxy-20-methyl-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetrone
 related_synonym: Formula=C21H33N3O6S2;   InChI=1S/C21H33N3O6S2/c1-4-12(2)19-16(25)10-18(27)30-14-7-5-6-8-31-32-11-15(21(29)24-19)23-20(28)13(3)22-17(26)9-14/h5,7,12-16,19,25H,4,6,8-11H2,1-3H3,(H,22,26)(H,23,28)(H,24,29)/b7-5+/t12-,13+,14+,15+,16-,19+/m0/s1;   InChIKey=MJHZJODQLYCXHE-WXZCCWHXSA-N;   SMILES=C1SSCCC=C[C@@H]2CC(N[C@@](C(N[C@H]1C(N[C@@]([C@H](CC(O2)=O)O)([C@H](CC)C)[H])=O)=O)(C)[H])=O
 xref_mesh: MESH:C529984
 xref: PMID:18368162;   PMID:19333864;   PMID:19760730;   PMID:21445425;   PMID:22211246;   PMID:25078973;   Reaxys:18598407



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spiruchostatin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist increases activity ISO spiruchostatin B results in increased activity of BID protein CTD PMID:25078973 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp3 caspase 3 increases activity ISO spiruchostatin B results in increased activity of CASP3 protein CTD PMID:25078973 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO spiruchostatin B results in increased activity of CASP8 protein CTD PMID:25078973 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      application 19486
        pharmaceutical 19335
          drug 19335
            antineoplastic agent 17378
              spiruchostatin B 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        carboacyl group 17490
                                          univalent carboacyl group 17490
                                            carbamoyl group 17304
                                              carboxamide 17304
                                                peptide 9461
                                                  depsipeptide 357
                                                    cyclodepsipeptide 338
                                                      spiruchostatin 3
                                                        spiruchostatin B 3
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