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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:9-(tetrahydrofuryl)adenine
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Accession:CHEBI:90232 term browser browse the term
Definition:A nucleoside analogue that is adenine in which the nitrogen at position 9 has been substituted by a tetrahydrofuran-2-yl group. It is an adenylate cyclase inhibitor.
Synonyms:exact_synonym: 9-(tetrahydrofuran-2-yl)-9H-purin-6-amine
 related_synonym: 6-amino-9-(tetrahydro-2-furyl)-9H-purine;   9-(tetrahydro-2-furanyl)-9H-purin-6-amine;   9-(tetrahydro-2-furyl)-adenine;   Formula=C9H11N5O;   InChI=1S/C9H11N5O/c10-8-7-9(12-4-11-8)14(5-13-7)6-2-1-3-15-6/h4-6H,1-3H2,(H2,10,11,12);   InChIKey=UKHMZCMKHPHFOT-UHFFFAOYSA-N;   SMILES=C12=C(N=CN1C3OCCC3)C(=NC=N2)N;   SQ 22,536;   SQ-22536;   SQ22536
 xref: CAS:17318-31-9;   LINCS:LSM-1656
 xref_mesh: MESH:C017759
 xref: PMID:10193763;   PMID:11334872;   PMID:11858802;   PMID:1669444;   PMID:1711430;   PMID:26350463;   PMID:6326343;   Reaxys:534250


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9-(tetrahydrofuryl)adenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gcg glucagon multiple interactions ISO 9-(tetrahydro-2-furyl)-adenine inhibits the reaction [geraniol results in increased secretion of GCG protein] CTD PMID:29070885 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases expression ISO 9-(tetrahydro-2-furyl)-adenine results in decreased expression of PNPLA6 mRNA; 9-(tetrahydro-2-furyl)-adenine results in decreased expression of PNPLA6 protein CTD PMID:20380879 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 9-(tetrahydro-2-furyl)-adenine inhibits the reaction [methylmercuric chloride results in increased expression of PTGS2 protein] CTD PMID:28958600 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        inhibitor 18895
          enzyme inhibitor 18723
            EC 4.* (lyase) inhibitor 7387
              EC 4.6.* (P-O lyase) inhibitor 75
                EC 4.6.1.1 (adenylate cyclase) inhibitor 5
                  9-(tetrahydrofuryl)adenine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic heterocyclic compound 18852
                                  organic heteropolycyclic compound 18295
                                    organic heterobicyclic compound 17240
                                      imidazopyrimidine 7717
                                        purines 7716
                                          aminopurine 6717
                                            6-aminopurines 1018
                                              adenine 1015
                                                9-(tetrahydrofuryl)adenine 3
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