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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:quizartinib
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Accession:CHEBI:90217 term browser browse the term
Definition:A member of the class of phenylureas that is urea in which one of the amino groups has been substituted by a 5-tert-butyl-1,2-oxazol-3-yl group while the other has been substituted by a phenyl group substituted at the para- position by an imidazo[2,1-b][1,3]benzothiazol-2-yl group that, in turn, is substituted at position 7 by a 2-(morpholin-4-yl)ethoxy group.
Synonyms:exact_synonym: 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea
 related_synonym: AC 010220;   AC 220;   AC010220;   AC220;   Formula=C29H32N6O4S;   InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36);   InChIKey=CVWXJKQAOSCOAB-UHFFFAOYSA-N;   N-(5-(1,1-Dimethylethyl)isoxazol-3-yl)-N'-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1-b)benzothiazol-2-yl)phenyl)urea;   SMILES=S1C2=C(N3C1=NC(=C3)C4=CC=C(NC(=O)NC5=NOC(C(C)(C)C)=C5)C=C4)C=CC(OCCN6CCOCC6)=C2;   quizartinibum
 alt_id: MESH:C544967
 xref: CAS:950769-58-1;   KEGG:D09955;   LINCS:LSM-1037
 xref_mesh: MESH:C544967
 xref: PDBeChem:P30;   PMID:19654408;   PMID:22875611;   PMID:23412931;   PMID:23497317;   PMID:23967177;   PMID:24070241;   PMID:24518522;   PMID:24883179;   PMID:25145428;   PMID:25775444;   PMID:25837374;   PMID:25847190;   Reaxys:12981016;   Wikipedia:Quizartinib


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quizartinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased phosphorylation of AKT1 protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of AKT1 protein] CTD PMID:25053825 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased expression of BCL2 protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased expression of BCL2 protein] CTD PMID:25053825 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression
ISO (+)-JQ1 compound promotes the reaction [quizartinib results in increased expression of BCL2L11 protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in increased expression of BCL2L11 protein] CTD PMID:25053825 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased expression of CDK4 protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK4 protein] CTD PMID:25053825 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased expression of CDK6 protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK6 protein] CTD PMID:25053825 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO (+)-JQ1 compound promotes the reaction [quizartinib results in increased expression of CDKN1A protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in increased expression of CDKN1A protein] CTD PMID:25053825 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Hexim1 HEXIM P-TEFb complex subunit 1 multiple interactions ISO quizartinib inhibits the reaction [(+)-JQ1 compound results in increased expression of HEXIM1 protein] CTD PMID:25053825 NCBI chr10:91,200,874...91,202,986
Ensembl chr10:91,200,874...91,202,984
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased phosphorylation of MAPK1 protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of MAPK1 protein] CTD PMID:25053825 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased phosphorylation of MAPK3 protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of MAPK3 protein] CTD PMID:25053825 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased expression of MYC protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased expression of MYC protein] CTD PMID:25053825 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO (+)-JQ1 compound promotes the reaction [quizartinib results in increased cleavage of PARP1 protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in increased cleavage of PARP1 protein] CTD PMID:25053825 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions
decreases phosphorylation
ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased phosphorylation of STAT5A protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5A protein] CTD PMID:25053825 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions
decreases phosphorylation
ISO (+)-JQ1 compound promotes the reaction [quizartinib results in decreased phosphorylation of STAT5B protein]; quizartinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5B protein] CTD PMID:25053825 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        pharmaceutical 19293
          drug 19293
            antineoplastic agent 17004
              quizartinib 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            carbamoyl group 17156
                                              carboxamide 17156
                                                monocarboxylic acid amide 14573
                                                  urea 4990
                                                    ureas 4987
                                                      phenylureas 1979
                                                        quizartinib 13
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