The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A racemate comprising equimolar amounts of (R)- and (S)-selisistat. It is a potent sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) and is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. The active isomer (EX-243) gives similar results and potency; the enantiomer (EX-242) is inactive.