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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tacedinaline
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Accession:CHEBI:90195 term browser browse the term
Definition:A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Also used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers.
Synonyms:exact_synonym: 4-acetamido-N-(2-aminophenyl)benzamide
 related_synonym: 4-(Acetylamino)-N-(2-aminophenyl)benzamide;   Acetyldinaline;   C.I. 994;   CI 994;   Formula=C15H15N3O2;   InChI=1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20);   InChIKey=VAZAPHZUAVEOMC-UHFFFAOYSA-N;   N-acetyldinaline;   SMILES=C1=C(C=CC(=C1)C(NC2=C(C=CC=C2)N)=O)NC(C)=O;   tacedinalina
 xref: CAS:112522-64-2;   KEGG:D05988;   LINCS:LSM-19036
 xref_mesh: MESH:C081895
 xref: PMID:25827403;   PMID:26365427;   Reaxys:8422586


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tacedinaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp8 caspase 8 multiple interactions ISO tacedinaline promotes the reaction [Decitabine results in increased expression of CASP8 protein] CTD PMID:21771726 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      chemical role 19250
        environmental contaminant 18575
          benzene 5593
            1,2-phenylenediamine 2540
              tacedinaline 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                monocarboxylic acid amide 14553
                                                  arenecarboxamide 6508
                                                    benzamides 6508
                                                      tacedinaline 1
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