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ONTOLOGY REPORT - ANNOTATIONS


Term:tacedinaline
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Accession:CHEBI:90195 term browser browse the term
Definition:A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Also used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers.
Synonyms:exact_synonym: 4-acetamido-N-(2-aminophenyl)benzamide
 related_synonym: 4-(Acetylamino)-N-(2-aminophenyl)benzamide;   Acetyldinaline;   C.I. 994;   CI 994;   Formula=C15H15N3O2;   InChI=1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20);   InChIKey=VAZAPHZUAVEOMC-UHFFFAOYSA-N;   N-acetyldinaline;   SMILES=C1=C(C=CC(=C1)C(NC2=C(C=CC=C2)N)=O)NC(C)=O;   tacedinalina
 xref: CAS:112522-64-2 "ChemIDplus";   CAS:112522-64-2 "KEGG COMPOUND";   KEGG:D05988;   LINCS:LSM-19036
 xref_mesh: MESH:C081895
 xref: PMID:25827403 "Europe PMC";   PMID:26365427 "SUBMITTER";   Reaxys:8422586 "Reaxys"


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tacedinaline term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      chemical role 19128
        environmental contaminant 18394
          benzene 5447
            1,2-phenylenediamine 2530
              tacedinaline 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                monocarboxylic acid amide 13180
                                                  arenecarboxamide 6406
                                                    benzamides 6406
                                                      tacedinaline 1
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