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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diaziquone
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Accession:CHEBI:90185 term browser browse the term
Definition:A 1,4-benzoquinone that is substituted at positions 2 and 5 have been replaced by aziridin-1-yl groups and at positions 3 and 6 by (ethoxycarbonyl)amino groups.
Synonyms:exact_synonym: diethyl [2,5-bis(aziridin-1-yl)-3,6-dioxocyclohexa-1,4-diene-1,4-diyl]biscarbamate
 related_synonym: 2,5-diaziridinyl-3,6-bis(carboethoxyamino)-1,4-benzoquinone;   3,6-bis(carboxyamino)-2,5-diaziridinyl-1,4-benzoquinone;   3,6-diaziridinyl-2,5-bis(ethoxycarbonylamino)-1,4-benzoquinone;   AZQ;   CI 904;   Formula=C16H20N4O6;   InChI=1S/C16H20N4O6/c1-3-25-15(23)17-9-11(19-5-6-19)14(22)10(18-16(24)26-4-2)12(13(9)21)20-7-8-20/h3-8H2,1-2H3,(H,17,23)(H,18,24);   InChIKey=WVYXNIXAMZOZFK-UHFFFAOYSA-N;   NSC 182968;   SMILES=C1(=C(C(C(=C(C1=O)N2CC2)NC(=O)OCC)=O)N3CC3)NC(=O)OCC;   aziridinylbenzoquinone;   diazicuona;   diaziquonum
 xref: CAS:57998-68-2;   Drug_Central:853;   KEGG:D03774
 xref_mesh: MESH:C029108
 xref: PMID:1301071;   PMID:1874603;   PMID:2651223;   PMID:2987424;   PMID:3440875;   PMID:6299094;   PMID:6381377;   PMID:6681775;   PMID:7180832;   Patent:US2913453;   Patent:US4146622;   Reaxys:1333277



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diaziquone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO diaziquone results in increased expression of CDKN1A mRNA
[NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; Acetylcysteine inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]; Dicumarol inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]
CTD PMID:8943236 PMID:9343371 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO diaziquone results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases activity
increases metabolic processing
multiple interactions
ISO [Dicumarol results in decreased activity of NQO1 protein] which results in decreased activity of diaziquone
NQO1 protein results in increased metabolism of diaziquone
[NQO1 protein results in increased metabolism of diaziquone] which results in increased abundance of Hydrogen Peroxide; [NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; NQO1 protein results in increased reduction of and results in increased activity of diaziquone
CTD PMID:2113030 PMID:9343371 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link

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  CHEBI ontology 19918
    role 19894
      application 19729
        pharmaceutical 19565
          drug 19565
            antineoplastic agent 17770
              diaziquone 3
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  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      ketone 17210
                                        cyclic ketone 15715
                                          quinone 8655
                                            benzoquinones 784
                                              1,4-benzoquinones 780
                                                diaziquone 3
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