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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diaziquone
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Accession:CHEBI:90185 term browser browse the term
Definition:A 1,4-benzoquinone that is substituted at positions 2 and 5 have been replaced by aziridin-1-yl groups and at positions 3 and 6 by (ethoxycarbonyl)amino groups.
Synonyms:exact_synonym: diethyl [2,5-bis(aziridin-1-yl)-3,6-dioxocyclohexa-1,4-diene-1,4-diyl]biscarbamate
 related_synonym: 2,5-diaziridinyl-3,6-bis(carboethoxyamino)-1,4-benzoquinone;   3,6-bis(carboxyamino)-2,5-diaziridinyl-1,4-benzoquinone;   3,6-diaziridinyl-2,5-bis(ethoxycarbonylamino)-1,4-benzoquinone;   AZQ;   CI 904;   Formula=C16H20N4O6;   InChI=1S/C16H20N4O6/c1-3-25-15(23)17-9-11(19-5-6-19)14(22)10(18-16(24)26-4-2)12(13(9)21)20-7-8-20/h3-8H2,1-2H3,(H,17,23)(H,18,24);   InChIKey=WVYXNIXAMZOZFK-UHFFFAOYSA-N;   NSC 182968;   SMILES=C1(=C(C(C(=C(C1=O)N2CC2)NC(=O)OCC)=O)N3CC3)NC(=O)OCC;   aziridinylbenzoquinone;   diazicuona;   diaziquonum
 xref: CAS:57998-68-2;   Drug_Central:853;   KEGG:D03774
 xref_mesh: MESH:C029108
 xref: PMID:1301071;   PMID:1874603;   PMID:2651223;   PMID:2987424;   PMID:3440875;   PMID:6299094;   PMID:6381377;   PMID:6681775;   PMID:7180832;   Patent:US2913453;   Patent:US4146622;   Reaxys:1333277


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diaziquone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO diaziquone results in increased expression of CDKN1A mRNA
[NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; Acetylcysteine inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]; Dicumarol inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]		 CTD PMID:8943236 PMID:9343371 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO diaziquone results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases activity
multiple interactions
increases metabolic processing		 ISO [Dicumarol results in decreased activity of NQO1 protein] which results in decreased activity of diaziquone
[NQO1 protein results in increased metabolism of diaziquone] which results in increased abundance of Hydrogen Peroxide; [NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; NQO1 protein results in increased reduction of and results in increased activity of diaziquone		 CTD PMID:2113030 PMID:9343371 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      application 19622
        pharmaceutical 19499
          drug 19499
            antineoplastic agent 17689
              diaziquone 3
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Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      ketone 17140
                                        cyclic ketone 15688
                                          quinone 8548
                                            benzoquinones 769
                                              1,4-benzoquinones 765
                                                diaziquone 3
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