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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Salvianolic acid A
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Accession:CHEBI:9017 term browser browse the term
Definition:A stilbenoid that has formula C26H22O10.
Synonyms:related_synonym: Formula=C26H22O10;   InChI=1S/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+/t23-/m1/s1;   InChIKey=YMGFTDKNIWPMGF-UCPJVGPRSA-N;   SMILES=OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\\C=C\\c1ccc(O)c(O)c1\\C=C\\c1ccc(O)c(O)c1
 xref: CAS:96574-01-5;   KEGG:C10492;   KNApSAcK:C00002772
 xref_mesh: MESH:C066201

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Salvianolic acid A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP salvianolic acid A inhibits the reaction [PDGFB protein results in increased expression of ACTA2 protein]; salvianolic acid A inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] CTD PMID:19822164 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP salvianolic acid A inhibits the reaction [arsenic trioxide results in increased expression of BAD protein] CTD PMID:28391263 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP salvianolic acid A inhibits the reaction [arsenic trioxide results in increased expression of BAX protein] CTD PMID:28391263 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP salvianolic acid A inhibits the reaction [arsenic trioxide results in decreased expression of BCL2 protein] CTD PMID:28391263 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO
EXP		 salvianolic acid A inhibits the reaction [Plant Extracts results in decreased expression of BCL2L1 protein]
salvianolic acid A inhibits the reaction [arsenic trioxide results in decreased expression of BCL2L1 protein]		 CTD PMID:23993977 PMID:28391263 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 salvianolic acid A inhibits the reaction [Plant Extracts results in increased expression of CASP3 protein]
salvianolic acid A inhibits the reaction [arsenic trioxide results in increased expression of CASP3 protein]; salvianolic acid A inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]		 CTD PMID:17244260 PMID:23993977 PMID:28391263 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase increases activity
multiple interactions		 ISO
EXP		 salvianolic acid A results in increased activity of CAT protein
salvianolic acid A inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein]		 CTD PMID:20882408 PMID:28391263 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP salvianolic acid A inhibits the reaction [Thioacetamide results in increased expression of CYBB protein] CTD PMID:19822164 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP salvianolic acid A inhibits the reaction [arsenic trioxide affects the localization of CYCS protein] CTD PMID:28391263 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO salvianolic acid A results in decreased activity of CYP2C8 protein CTD PMID:29689254 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO salvianolic acid A results in decreased activity of CYP2J2 protein CTD PMID:29689254 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein] CTD PMID:31654708 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO
EXP		 salvianolic acid A inhibits the reaction [Arsenic Trioxide results in decreased expression of DNM1L protein] CTD PMID:29867492 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein] CTD PMID:31654708 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF2S1 protein] CTD PMID:31654708 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
G Ifng interferon gamma multiple interactions ISO salvianolic acid A inhibits the reaction [Plant Extracts results in increased expression of IFNG protein] CTD PMID:23993977 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP salvianolic acid A inhibits the reaction [Thioacetamide results in increased expression of IL1B protein] CTD PMID:19822164 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 salvianolic acid A inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]		 CTD PMID:19822164 PMID:31654708 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO salvianolic acid A results in decreased phosphorylation of MAPK1 protein CTD PMID:29385302 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO salvianolic acid A results in decreased phosphorylation of MAPK3 protein CTD PMID:29385302 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] CTD PMID:31654708 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mfn1 mitofusin 1 multiple interactions ISO
EXP		 salvianolic acid A inhibits the reaction [Arsenic Trioxide results in increased expression of MFN1 protein] CTD PMID:29867492 NCBI chr 2:118,929,738...118,971,689
Ensembl chr 2:118,929,738...118,973,698 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO
EXP		 salvianolic acid A inhibits the reaction [Arsenic Trioxide results in increased expression of MFN2 protein] CTD PMID:29867492 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO salvianolic acid A results in decreased expression of and results in decreased activity of MMP2 protein; U 0126 promotes the reaction [salvianolic acid A results in decreased activity of MMP2 protein]
salvianolic acid A results in decreased expression of MMP2 mRNA		 CTD PMID:29385302 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] CTD PMID:31654708 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO		 salvianolic acid A inhibits the reaction [Thioacetamide results in increased expression of NOS2 protein]
salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]		 CTD PMID:19822164 PMID:31654708 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP
ISO		 salvianolic acid A inhibits the reaction [Arsenic Trioxide results in increased expression of OPA1 protein] CTD PMID:29867492 NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP salvianolic acid A inhibits the reaction [arsenic trioxide results in increased expression of PARP1 protein] CTD PMID:28391263 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP salvianolic acid A inhibits the reaction [PDGFB protein results in increased abundance of Hydrogen Peroxide]; salvianolic acid A inhibits the reaction [PDGFB protein results in increased expression of ACTA2 protein] CTD PMID:19822164 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP		 salvianolic acid A inhibits the reaction [Arsenic Trioxide results in decreased expression of PPARGC1A protein] CTD PMID:29867492 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:31654708 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO salvianolic acid A results in decreased phosphorylation of PTK2 protein CTD PMID:29385302 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation ISO salvianolic acid A results in decreased phosphorylation of RAF1 protein CTD PMID:29385302 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699 		JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions ISO salvianolic acid A inhibits the reaction [Plant Extracts results in increased expression of SHC1 mRNA]; salvianolic acid A inhibits the reaction [Plant Extracts results in increased expression of SHC1 protein] CTD PMID:23993977 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Plant Extracts promotes the reaction [salvianolic acid A results in increased expression of SIRT1 mRNA]; Plant Extracts promotes the reaction [salvianolic acid A results in increased expression of SIRT1 protein]; salvianolic acid A promotes the reaction [Plant Extracts results in increased expression of SIRT1 mRNA]; salvianolic acid A promotes the reaction [Plant Extracts results in increased expression of SIRT1 protein] CTD PMID:23993977 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Sod1 superoxide dismutase 1 increases activity ISO salvianolic acid A results in increased activity of SOD1 protein CTD PMID:20882408 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation ISO salvianolic acid A results in decreased phosphorylation of SRC protein CTD PMID:29385302 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:31654708 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 salvianolic acid A inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; salvianolic acid A inhibits the reaction [Thioacetamide results in increased expression of TNF protein]
salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; salvianolic acid A inhibits the reaction [Plant Extracts results in increased expression of TNF protein]		 CTD PMID:17244260 PMID:19822164 PMID:23993977 PMID:31654708 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    chemical entity 19875
      atom 19873
        nonmetal atom 19751
          carbon atom 19657
            organic molecular entity 19657
              olefinic compound 14850
                stilbenoid 5644
                  Salvianolic acid A 39
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic molecule 19586
                              organic cyclic compound 19395
                                organic aromatic compound 19220
                                  stilbenoid 5644
                                    Salvianolic acid A 39
paths to the root