CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: salsalate
Accession: CHEBI:9014
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Definition: A dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthritis and also shows activity against type II diabetes.
Synonyms: exact_synonym: 2-[(2-hydroxybenzoyl)oxy]benzoic acid
related_synonym: 2-Carboxyphenyl salicylate; Disalcid; Disalicylic acid; Disalicylsaeure; Formula=C14H10O5; InChI=1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17); InChIKey=WVYADZUPLLSGPU-UHFFFAOYSA-N; O-Salicylcylsalicylsaeure; SMILES=OC(=O)c1ccccc1OC(=O)c1ccccc1O; Salicylic acid bimolecular ester; Salicyloxysalicylic acid; Salicyloylsalicylic acid; Sasapyrin; Sasapyrine; Sasapyrinum; o-Salicylsalicylic acid; salicylsalicylic acid; salsalato; salsalatum
xref: CAS:552-94-3; DrugBank:DB01399; Drug_Central:2420; KEGG:D00428
xref_mesh: MESH:C014182
xref: PMID:19747808; PMID:20613460; PMID:20876710; PMID:21289240; PMID:21519323; PMID:21617098; PMID:21764223; PMID:21903749; PMID:21938543; PMID:22357964; PMID:22388922; PMID:22517326; PMID:22782506; PMID:22784842; PMID:23370525; PMID:23680037; PMID:23801715; PMID:23817699; PMID:23817718; PMID:23825542; PMID:23871515; PMID:23948064; PMID:24130358; PMID:28166217; Reaxys:2590908; Wikipedia:Salsalate
G
Il6
interleukin 6
affects expression
EXP
salicylsalicylic acid affects the expression of IL6 protein
CTD
PMID:20876710
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Nos3
nitric oxide synthase 3
multiple interactions
EXP
salicylsalicylic acid affects the expression of and affects the phosphorylation of NOS3 protein
CTD
PMID:20876710
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
G
Rela
RELA proto-oncogene, NF-kB subunit
affects expression
EXP
salicylsalicylic acid affects the expression of RELA protein
CTD
PMID:20876710
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Sod2
superoxide dismutase 2
affects expression
EXP
salicylsalicylic acid affects the expression of SOD2 protein
CTD
PMID:20876710
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
G
Vegfa
vascular endothelial growth factor A
affects expression
EXP
salicylsalicylic acid affects the expression of VEGFA protein
CTD
PMID:20876710
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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