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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:salsalate
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Accession:CHEBI:9014 term browser browse the term
Definition:A dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthritis and also shows activity against type II diabetes.
Synonyms:exact_synonym: 2-[(2-hydroxybenzoyl)oxy]benzoic acid
 related_synonym: 2-Carboxyphenyl salicylate;   Disalcid;   Disalicylic acid;   Disalicylsaeure;   Formula=C14H10O5;   InChI=1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17);   InChIKey=WVYADZUPLLSGPU-UHFFFAOYSA-N;   O-Salicylcylsalicylsaeure;   SMILES=OC(=O)c1ccccc1OC(=O)c1ccccc1O;   Salicylic acid bimolecular ester;   Salicyloxysalicylic acid;   Salicyloylsalicylic acid;   Sasapyrin;   Sasapyrine;   Sasapyrinum;   o-Salicylsalicylic acid;   salicylsalicylic acid;   salsalato;   salsalatum
 xref: CAS:552-94-3;   DrugBank:DB01399;   Drug_Central:2420;   KEGG:D00428
 xref_mesh: MESH:C014182
 xref: PMID:19747808;   PMID:20613460;   PMID:20876710;   PMID:21289240;   PMID:21519323;   PMID:21617098;   PMID:21764223;   PMID:21903749;   PMID:21938543;   PMID:22357964;   PMID:22388922;   PMID:22517326;   PMID:22782506;   PMID:22784842;   PMID:23370525;   PMID:23680037;   PMID:23801715;   PMID:23817699;   PMID:23817718;   PMID:23825542;   PMID:23871515;   PMID:23948064;   PMID:24130358;   PMID:28166217;   Reaxys:2590908;   Wikipedia:Salsalate



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salsalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 affects expression EXP salicylsalicylic acid affects the expression of IL6 protein CTD PMID:20876710 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP salicylsalicylic acid affects the expression of and affects the phosphorylation of NOS3 protein CTD PMID:20876710 NCBI chr 4:11,686,088...11,706,604 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects expression EXP salicylsalicylic acid affects the expression of RELA protein CTD PMID:20876710 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Sod2 superoxide dismutase 2 affects expression EXP salicylsalicylic acid affects the expression of SOD2 protein CTD PMID:20876710 NCBI chr 1:50,043,323...50,050,168 JBrowse link
G Vegfa vascular endothelial growth factor A affects expression EXP salicylsalicylic acid affects the expression of VEGFA protein CTD PMID:20876710 NCBI chr 9:22,452,854...22,468,194 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      application 19715
        pro-agent 11569
          prodrug 11313
            salsalate 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organochalcogen compound 19296
                                organooxygen compound 19213
                                  carbon oxoacid 18682
                                    carboxylic acid 18679
                                      aromatic carboxylic acid 12748
                                        benzoic acids 12726
                                          benzoic acid 5521
                                            hydroxybenzoic acid 4996
                                              monohydroxybenzoic acid 2821
                                                salicylic acid 1571
                                                  salsalate 5
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