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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:9014 term browser browse the term
Definition:A dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthritis and also shows activity against type II diabetes.
Synonyms:exact_synonym: 2-[(2-hydroxybenzoyl)oxy]benzoic acid
 related_synonym: 2-Carboxyphenyl salicylate;   Disalcid;   Disalicylic acid;   Disalicylsaeure;   Formula=C14H10O5;   InChI=1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17);   InChIKey=WVYADZUPLLSGPU-UHFFFAOYSA-N;   O-Salicylcylsalicylsaeure;   SMILES=OC(=O)c1ccccc1OC(=O)c1ccccc1O;   Salicylic acid bimolecular ester;   Salicyloxysalicylic acid;   Salicyloylsalicylic acid;   Sasapyrin;   Sasapyrine;   Sasapyrinum;   o-Salicylsalicylic acid;   salicylsalicylic acid;   salsalato;   salsalatum
 xref: CAS:552-94-3;   DrugBank:DB01399;   Drug_Central:2420;   KEGG:D00428
 xref_mesh: MESH:C014182
 xref: PMID:19747808;   PMID:20613460;   PMID:20876710;   PMID:21289240;   PMID:21519323;   PMID:21617098;   PMID:21764223;   PMID:21903749;   PMID:21938543;   PMID:22357964;   PMID:22388922;   PMID:22517326;   PMID:22782506;   PMID:22784842;   PMID:23370525;   PMID:23680037;   PMID:23801715;   PMID:23817699;   PMID:23817718;   PMID:23825542;   PMID:23871515;   PMID:23948064;   PMID:24130358;   PMID:28166217;   Reaxys:2590908;   Wikipedia:Salsalate

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salsalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 affects expression EXP salicylsalicylic acid affects the expression of IL6 protein CTD PMID:20876710 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP salicylsalicylic acid affects the expression of and affects the phosphorylation of NOS3 protein CTD PMID:20876710 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects expression EXP salicylsalicylic acid affects the expression of RELA protein CTD PMID:20876710 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sod2 superoxide dismutase 2 affects expression EXP salicylsalicylic acid affects the expression of SOD2 protein CTD PMID:20876710 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Vegfa vascular endothelial growth factor A affects expression EXP salicylsalicylic acid affects the expression of VEGFA protein CTD PMID:20876710 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      application 19745
        pro-agent 10144
          prodrug 9948
            salsalate 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        aromatic carboxylic acid 11788
                                          benzoic acids 11763
                                            benzoic acid 4328
                                              hydroxybenzoic acid 3734
                                                monohydroxybenzoic acid 1459
                                                  salicylic acid 942
                                                    salsalate 5
paths to the root