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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:salsalate
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Accession:CHEBI:9014 term browser browse the term
Definition:A dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthritis and also shows activity against type II diabetes.
Synonyms:exact_synonym: 2-[(2-hydroxybenzoyl)oxy]benzoic acid
 related_synonym: 2-Carboxyphenyl salicylate;   Disalcid;   Disalicylic acid;   Disalicylsaeure;   Formula=C14H10O5;   InChI=1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17);   InChIKey=WVYADZUPLLSGPU-UHFFFAOYSA-N;   O-Salicylcylsalicylsaeure;   SMILES=OC(=O)c1ccccc1OC(=O)c1ccccc1O;   Salicylic acid bimolecular ester;   Salicyloxysalicylic acid;   Salicyloylsalicylic acid;   Sasapyrin;   Sasapyrine;   Sasapyrinum;   o-Salicylsalicylic acid;   salicylsalicylic acid;   salsalato;   salsalatum
 xref: CAS:552-94-3;   DrugBank:DB01399;   Drug_Central:2420;   KEGG:D00428
 xref_mesh: MESH:C014182
 xref: PMID:19747808;   PMID:20613460;   PMID:20876710;   PMID:21289240;   PMID:21519323;   PMID:21617098;   PMID:21764223;   PMID:21903749;   PMID:21938543;   PMID:22357964;   PMID:22388922;   PMID:22517326;   PMID:22782506;   PMID:22784842;   PMID:23370525;   PMID:23680037;   PMID:23801715;   PMID:23817699;   PMID:23817718;   PMID:23825542;   PMID:23871515;   PMID:23948064;   PMID:24130358;   PMID:28166217;   Reaxys:2590908;   Wikipedia:Salsalate


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salsalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 affects expression EXP salicylsalicylic acid affects the expression of IL6 protein CTD PMID:20876710 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP salicylsalicylic acid affects the expression of and affects the phosphorylation of NOS3 protein CTD PMID:20876710 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects expression EXP salicylsalicylic acid affects the expression of RELA protein CTD PMID:20876710 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sod2 superoxide dismutase 2 affects expression EXP salicylsalicylic acid affects the expression of SOD2 protein CTD PMID:20876710 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Vegfa vascular endothelial growth factor A affects expression EXP salicylsalicylic acid affects the expression of VEGFA protein CTD PMID:20876710 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        pro-agent 10095
          prodrug 9899
            salsalate 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        aromatic carboxylic acid 11708
                                          benzoic acids 11681
                                            benzoic acid 4157
                                              hydroxybenzoic acid 3562
                                                monohydroxybenzoic acid 1290
                                                  salicylic acid 771
                                                    salsalate 5
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