Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cyclo(L-His-L-Pro)
go back to main search page
Accession:CHEBI:90039 term browser browse the term
Definition:A homodetic cyclic peptide resulting from the formal condensation of both the amino and acid groups of L-histidine with the acid and amino groups of L-proline. It is a metabolite of thyrotropin-releasing hormone (TRH).
Synonyms:exact_synonym: (3S,8aS)-3-[(1H-imidazol-5-yl)methyl]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
 related_synonym: Cyclo(his-pro);   Cyclo(histidyl-prolyl);   Formula=C11H14N4O2;   His-pro-DKP;   Histidyl-proline-diketopiperazine;   InChI=1S/C11H14N4O2/c16-10-9-2-1-3-15(9)11(17)8(14-10)4-7-5-12-6-13-7/h5-6,8-9H,1-4H2,(H,12,13)(H,14,16)/t8-,9-/m0/s1;   InChIKey=NAKUGCPAQTUSBE-IUCAKERBSA-N;   L,L-cyclo(histidylprolyl);   L-His-L-Pro-DKP;   L-histidyl-L-proline diketopiperazine;   SMILES=O=C1N2CCC[C@]2(C(=O)N[C@H]1CC=3NC=NC3)[H];   histidylproline diketopiperazine
 alt_id: CHEBI:41471
 xref: CAS:53109-32-3;   FooDB:FDB022818;   HMDB:HMDB0002053;   PDBeChem:CHQ;   PMID:15509170;   PMID:21364307;   PMID:22185821;   PMID:2501708;   PMID:2512185;   PMID:27529240;   PMID:29708066;   PMID:3003820;   PMID:30439413;   PMID:3102558;   PMID:3129742;   PMID:3251576;   PMID:3840081;   PMID:6248056;   PMID:6278283;   PMID:6398951;   PMID:6401750;   PMID:6672793;   PMID:7679984


show annotations for term's descendants           Sort by:
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      application 21760
        anti-inflammatory agent 17357
          cyclo(L-His-L-Pro) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            heteroorganic entity 21500
                              organochalcogen compound 20983
                                organooxygen compound 20824
                                  carbon oxoacid 19606
                                    carboxylic acid 19602
                                      carboacyl group 18299
                                        univalent carboacyl group 18299
                                          carbamoyl group 18110
                                            carboxamide 18110
                                              peptide 11233
                                                cyclic peptide 8986
                                                  homodetic cyclic peptide 8481
                                                    cyclo(L-His-L-Pro) 0
paths to the root