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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyclo(L-His-L-Pro)
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Accession:CHEBI:90039 term browser browse the term
Definition:A homodetic cyclic peptide resulting from the formal condensation of both the amino and acid groups of L-histidine with the acid and amino groups of L-proline. It is a metabolite of thyrotropin-releasing hormone (TRH).
Synonyms:exact_synonym: (3S,8aS)-3-[(1H-imidazol-5-yl)methyl]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
 related_synonym: Cyclo(his-pro);   Cyclo(histidyl-prolyl);   Formula=C11H14N4O2;   His-pro-DKP;   Histidyl-proline-diketopiperazine;   InChI=1S/C11H14N4O2/c16-10-9-2-1-3-15(9)11(17)8(14-10)4-7-5-12-6-13-7/h5-6,8-9H,1-4H2,(H,12,13)(H,14,16)/t8-,9-/m0/s1;   InChIKey=NAKUGCPAQTUSBE-IUCAKERBSA-N;   L,L-cyclo(histidylprolyl);   L-His-L-Pro-DKP;   SMILES=O=C1N2CCC[C@]2(C(=O)N[C@H]1CC=3NC=NC3)[H];   histidylproline diketopiperazine
 alt_id: CHEBI:41471
 xref: CAS:53109-32-3;   FooDB:FDB022818;   HMDB:HMDB0002053;   PDBeChem:CHQ;   PMID:15509170;   PMID:21364307;   PMID:22185821;   PMID:2501708;   PMID:2512185;   PMID:27529240;   PMID:29708066;   PMID:3003820;   PMID:30439413;   PMID:3102558;   PMID:3129742;   PMID:3251576;   PMID:3840081;   PMID:6248056;   PMID:6278283;   PMID:6398951;   PMID:6401750;   PMID:6672793;   PMID:7679984


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  CHEBI ontology 19770
    role 19718
      application 19363
        anti-inflammatory agent 14939
          cyclo(L-His-L-Pro) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            organic group 18488
                              organic divalent group 18481
                                organodiyl group 18481
                                  carbonyl group 18384
                                    carbonyl compound 18384
                                      carboxylic acid 18054
                                        carboacyl group 17334
                                          univalent carboacyl group 17334
                                            carbamoyl group 17118
                                              carboxamide 17118
                                                peptide 9368
                                                  cyclic peptide 8720
                                                    homodetic cyclic peptide 8309
                                                      cyclo(L-His-L-Pro) 0
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