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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:glycoursodeoxycholic acid
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Accession:CHEBI:89929 term browser browse the term
Definition:A bile acid glycine conjugate derived from ursoodeoxycholic acid.
Synonyms:related_synonym: 3alpha,7beta-dihydroxy-5beta-cholanoylglycine;   Formula=C26H43NO5;   GUDCA;   Glycine ursodeoxycholic acid;   Glycylursodeoxycholic acid;   InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/t15-,16+,17-,18-,19+,20+,21+,24+,25+,26-/m1/s1;   InChIKey=GHCZAUBVMUEKKP-XROMFQGDSA-N;   N-(3alpha,7beta-dihydroxy-5beta-cholan-24-oyl)glycine;   N-[(3alpha,5beta,7beta)-3,7-dihydroxy-24-oxocholan-24-yl]glycine;   SMILES=C1[C@@]2([C@]3(CC[C@]4([C@]([C@@]3([C@H](C[C@@]2(C[C@@H](C1)O)[H])O)[H])(CC[C@]4([H])[C@@H](CCC(NCC(O)=O)=O)C)[H])C)[H])C;   Ursodeoxycholylglycine
 xref: CAS:64480-66-6;   HMDB:HMDB0000708
 xref_mesh: MESH:C024033
 xref: PMID:24848512;   PMID:26009005;   PMID:26382575;   PMID:26639449;   PMID:27322559;   Reaxys:3226178
 cyclic_relationship: is_conjugate_acid_of CHEBI:132030


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glycoursodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP glycoursodeoxycholic acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA] CTD PMID:17881359 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Edn1 endothelin 1 decreases expression ISO glycoursodeoxycholic acid results in decreased expression of EDN1 protein CTD PMID:15556138 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Slc4a2 solute carrier family 4 member 2 multiple interactions ISO [glycoursodeoxycholic acid co-treated with Dexamethasone] results in increased expression of SLC4A2 mRNA alternative form CTD PMID:18188457 NCBI chr 4:7,264,677...7,282,355
Ensembl chr 4:7,264,683...7,281,223
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP glycoursodeoxycholic acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA] CTD PMID:17881359 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

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  CHEBI ontology 19817
    role 19767
      application 19445
        pharmaceutical 19319
          drug 19319
            protective agent 16384
              neuroprotective agent 15494
                glycoursodeoxycholic acid 4
Path 2
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  CHEBI ontology 19817
    subatomic particle 19815
      composite particle 19815
        hadron 19815
          baryon 19815
            nucleon 19815
              atomic nucleus 19815
                atom 19815
                  main group element atom 19705
                    p-block element atom 19705
                      carbon group element atom 19614
                        carbon atom 19603
                          organic molecular entity 19603
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18435
                                    carbonyl compound 18435
                                      carboxylic acid 18113
                                        amino acid 14113
                                          alpha-amino acid 11599
                                            L-alpha-amino acid 11435
                                              serine family amino acid 2058
                                                glycine 1212
                                                  glycine derivative 1201
                                                    N-acylglycine 21
                                                      glycoursodeoxycholic acid 4
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