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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:SB 206553
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Accession:CHEBI:8977 term browser browse the term
Definition:A pyrroloindole that has formula C17H16N4O.
Synonyms:related_synonym: Formula=C17H16N4O;   InChI=1S/C17H16N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22);   InChIKey=QJQORSLQNXDVGE-UHFFFAOYSA-N;   SMILES=Cn1ccc2cc3N(CCc3cc12)C(=O)Nc1cccnc1
 xref: KEGG:C11740;   LINCS:LSM-2800
 xref_mesh: MESH:C094868


show annotations for term's descendants           Sort by:
SB 206553 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP SB 206553 inhibits the reaction [Fluoxetine results in increased expression of FOS protein] CTD PMID:16521035 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions EXP [volinanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [SB 206553 results in increased susceptibility to Methamphetamine] CTD PMID:11751031 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B multiple interactions EXP SB 206553 binds to and results in decreased activity of HTR2B protein CTD PMID:16521035 NCBI chr 9:86,735,793...86,756,638
Ensembl chr 9:86,742,102...86,755,108 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C increases expression
multiple interactions		 ISO
EXP		 SB 206553 results in increased expression of HTR2C protein
SB 206553 binds to and results in decreased activity of HTR2C protein		 CTD PMID:16521035 PMID:18083778 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO SB 206553 inhibits the reaction [Isoproterenol results in increased expression of IL1B] CTD PMID:15302781 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO SB 206553 inhibits the reaction [Isoproterenol results in increased expression of IL6] CTD PMID:15302781 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO SB 206553 inhibits the reaction [Isoproterenol results in increased expression of TNF] CTD PMID:15302781 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      atom 19809
        nonmetal atom 19747
          nitrogen atom 18962
            nitrogen molecular entity 18934
              organonitrogen compound 18783
                organonitrogen heterocyclic compound 18154
                  pyrroloindole 8
                    SB 206553 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            organic molecule 19658
                              organic cyclic compound 19471
                                organic heterocyclic compound 18862
                                  organic heteropolycyclic compound 18301
                                    organic heterotricyclic compound 15641
                                      pyrroloindole 8
                                        SB 206553 7
paths to the root