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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5-hydroxyindole
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Accession:CHEBI:89649 term browser browse the term
Definition:A member of the class of hydroxyindoles that is 1H-indole in which the hydrogen at position 5 has been replaced by a hydroxy group.
Synonyms:exact_synonym: 1H-indol-5-ol
 related_synonym: 5-hydroxy-1H-indole;   Formula=C8H7NO;   InChI=1S/C8H7NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-5,9-10H;   InChIKey=LMIQERWZRIFWNZ-UHFFFAOYSA-N;   SMILES=C=1C=C2C(C=CN2)=CC1O;   indol-5-ol
 xref: CAS:1953-54-4;   HMDB:HMDB0059805
 xref_mesh: MESH:C026785
 xref: MetaCyc:CPD-16174;   PMID:21784895;   PMID:24029555;   PMID:5294372;   PMID:5294373;   Reaxys:112349



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5-hydroxyindole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions EXP 5-hydroxyindole binds to and results in increased activity of CHRNA7 protein; [3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein; methyllycaconitine inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein]; Tetrodotoxin inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein] CTD PMID:18321476 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
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G Sult1a1 sulfotransferase family 1A member 1 increases sulfation EXP
ISO
SULT1A1 protein results in increased sulfation of 5-hydroxyindole CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19808
      molecular entity 19807
        polyatomic entity 19728
          heteroatomic molecular entity 19669
            hydroxides 19171
              organic hydroxy compound 18666
                hydroxyindoles 164
                  5-hydroxyindole 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic molecule 19556
                              organic cyclic compound 19347
                                organic heterocyclic compound 18580
                                  organic heteropolycyclic compound 18057
                                    organic heterobicyclic compound 16867
                                      benzopyrrole 9560
                                        indoles 9232
                                          hydroxyindoles 164
                                            5-hydroxyindole 2
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