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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-hydroxyindole
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Accession:CHEBI:89649 term browser browse the term
Definition:A member of the class of hydroxyindoles that is 1H-indole in which the hydrogen at position 5 has been replaced by a hydroxy group.
Synonyms:exact_synonym: 1H-indol-5-ol
 related_synonym: 5-hydroxy-1H-indole;   Formula=C8H7NO;   InChI=1S/C8H7NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-5,9-10H;   InChIKey=LMIQERWZRIFWNZ-UHFFFAOYSA-N;   SMILES=C=1C=C2C(C=CN2)=CC1O;   indol-5-ol
 xref: CAS:1953-54-4;   HMDB:HMDB0059805
 xref_mesh: MESH:C026785
 xref: MetaCyc:CPD-16174;   PMID:21784895;   PMID:24029555;   PMID:5294372;   PMID:5294373;   Reaxys:112349


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5-hydroxyindole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions EXP 5-hydroxyindole binds to and results in increased activity of CHRNA7 protein; [3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein; methyllycaconitine inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein]; Tetrodotoxin inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein] CTD PMID:18321476 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation EXP
ISO		 SULT1A1 protein results in increased sulfation of 5-hydroxyindole CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      molecular entity 19872
        polyatomic entity 19824
          heteroatomic molecular entity 19781
            hydroxides 19341
              organic hydroxy compound 18951
                hydroxyindoles 180
                  5-hydroxyindole 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteropolycyclic compound 18294
                                    organic heterobicyclic compound 17237
                                      benzopyrrole 9739
                                        indoles 9427
                                          hydroxyindoles 180
                                            5-hydroxyindole 2
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