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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:18-hydroxycortisol
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Accession:CHEBI:89455 term browser browse the term
Definition:A 18-hydroxy steroid that is cortisol carrying a hydroxy group at position 18. Its urinary excretion is increased in patients with aldosterone-producing adenoma.
Synonyms:exact_synonym: 11beta,17,18,21-tetrahydroxypregn-4-ene-3,20-dione
 related_synonym: (11beta)-11,17,18,21-tetrahydroxypregn-4-ene-3,20-dione;   (11beta,17alpha)-11,17,18,21-tetrahydroxypregn-4-ene-3,20-dione;   4-pregnene-11beta,17,18,21-tetrol-3,20-dione;   Formula=C21H30O6;   InChI=1S/C21H30O6/c1-19-6-4-13(24)8-12(19)2-3-14-15-5-7-21(27,17(26)10-22)20(15,11-23)9-16(25)18(14)19/h8,14-16,18,22-23,25,27H,2-7,9-11H2,1H3/t14-,15-,16-,18+,19-,20+,21+/m0/s1;   InChIKey=HESFZGWRDUVOMS-UKSDXMLSSA-N;   SMILES=[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(CO)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
 xref: CAS:86002-90-6;   FooDB:FDB022033;   HMDB:HMDB0000418;   LIPID_MAPS_instance:LMST02030295
 xref_mesh: MESH:C033689
 xref: PMID:10778083;   PMID:11566957;   PMID:12429142;   PMID:15062555;   PMID:15356073;   PMID:1560187;   PMID:1567095;   PMID:15941931;   PMID:16149517;   PMID:1879399;   PMID:20963880;   PMID:22238407;   PMID:23847032;   PMID:2811370;   PMID:28904009;   PMID:3002670;   PMID:34871919;   PMID:35778951;   PMID:3995762;   PMID:8001289;   PMID:8038908;   PMID:8049145;   PMID:8516344;   PMID:8753282;   PMID:9090795;   PMID:9279964;   PMID:9814482;   PMID:9831489;   Wikipedia:18-Hydroxycortisol


show annotations for term's descendants           Sort by:
18-hydroxycortisol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 affects chemical synthesis ISO CYP11B1 protein affects the chemical synthesis of 18-hydroxycortisol CTD PMID:15356073 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects chemical synthesis ISO CYP11B2 protein affects the chemical synthesis of 18-hydroxycortisol CTD PMID:15356073 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Pomc proopiomelanocortin increases abundance ISO POMC protein results in increased abundance of 18-hydroxycortisol CTD PMID:3015796 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      application 19741
        anti-inflammatory agent 16638
          anti-inflammatory drug 14985
            cortisol 276
              18-hydroxycortisol 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            heteroorganic entity 19559
                              organochalcogen compound 19317
                                organooxygen compound 19231
                                  carbonyl compound 18945
                                    ketone 17194
                                      oxyketone 8915
                                        alpha-oxyketone 8915
                                          alpha-hydroxy ketone 8915
                                            primary alpha-hydroxy ketone 7797
                                              cortisol 276
                                                18-hydroxycortisol 3
paths to the root