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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ryanodine
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Accession:CHEBI:8925 term browser browse the term
Definition:An insecticide alkaloid isolated from South American plant Ryania speciosa.
Synonyms:exact_synonym: (3S,4R,4aR,6S,6aR,7S,8R,8aS,8bR,9S,9aS)-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(propan-2-yl)dodecahydro-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl 1H-pyrrole-2-carboxylate
 related_synonym: (3S,4R,4aR,6S,6aR,7S,8R,8aS,8bR,9S,9aS)-4,6,7,8a,8b,9a-hexahydroxy-7-isopropyl-3,6a,9-trimethyldodecahydro-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl 1H-pyrrole-2-carboxylate;   Formula=C25H35NO9;   InChI=1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19+,20-,21-,22+,23+,24+,25+/m0/s1;   InChIKey=JJSYXNQGLHBRRK-SFEDZAPPSA-N;   Ryania;   Ryanodin;   SMILES=CC(C)[C@@]1(O)[C@@H](OC(=O)c2ccc[nH]2)[C@@]2(O)[C@@]3(C)C[C@]4(O)O[C@@]5([C@H](O)[C@@H](C)CC[C@]35O)[C@@]2(O)[C@@]14C;   ryanodol, 3-(1H-pyrrole-2-carboxylate)
 xref: BPDB:2067;   Beilstein:6079034;   CAS:15662-33-6;   KEGG:C08705;   KNApSAcK:C00001661
 xref_mesh: MESH:D012433


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ryanodine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RYR1 ryanodine receptor 1 affects binding
multiple interactions		 EXP Ryanodine binds to RYR1 protein; Ryanodine binds to RYR1 protein mutant form
5'-adenylyl (beta,gamma-methylene)diphosphonate affects the reaction [Ryanodine binds to RYR1 protein]; Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]; Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]; Dantrolene inhibits the reaction [Ryanodine binds to RYR1 protein mutant form]; Dantrolene inhibits the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Strontium promotes the reaction [Ryanodine binds to RYR1 protein]]; Strontium promotes the reaction [Ryanodine binds to RYR1 protein mutant form]; Strontium promotes the reaction [Ryanodine binds to RYR1 protein]		 CTD PMID:11278295 NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458 		JBrowse link
G RYR2 ryanodine receptor 2 affects binding EXP Ryanodine binds to RYR2 protein CTD PMID:11278295 NCBI chr14:53,652,140...54,406,691
Ensembl chr14:53,652,485...54,192,063 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5052
    role 5044
      biological role 5016
        biochemical role 4938
          metabolite 4926
            alkaloid 74
              ryanodine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 5052
    subatomic particle 5043
      composite particle 5043
        hadron 5071
          baryon 5043
            nucleon 5043
              atomic nucleus 5043
                atom 5043
                  main group element atom 5013
                    p-block element atom 5010
                      chalcogen 4915
                        oxygen atom 4910
                          oxygen molecular entity 4883
                            hydroxides 4835
                              organic hydroxy compound 4767
                                alcohol 4402
                                  hemiacetal 4
                                    lactol 4
                                      cyclic hemiketal 4
                                        ryanodine 2
paths to the root