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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:rottlerin
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Accession:CHEBI:8899 term browser browse the term
Definition:A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis.
Synonyms:exact_synonym: (2E)-1-[6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-3-phenylprop-2-en-1-one
 related_synonym: 3'-((8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl)-2',4',6'-trihydroxy-5'-methyl-acetophenone;   Formula=C30H28O8;   InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+;   InChIKey=DEZFNHCVIZBHBI-ZHACJKMWSA-N;   Kamalin;   Mallotoxin;   SMILES=CC(=O)c1c(O)c(C)c(O)c(Cc2c(O)c3C=CC(C)(C)Oc3c(C(=O)\\C=C\\c3ccccc3)c2O)c1O
 xref: CAS:82-08-6;   KEGG:C10721;   KNApSAcK:C00002708;   LIPID_MAPS_instance:LMPK12120428
 xref_mesh: MESH:C085746
 xref: PMID:21415309;   PMID:22272173;   PMID:22410117;   PMID:22490701;   PMID:22758638;   PMID:22970301;   PMID:23632085;   Patent:EP2578210;   Patent:US2011112182;   Reaxys:70757;   Wikipedia:Rottlerin


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rottlerin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO rottlerin inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein] CTD PMID:17030193 NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 multiple interactions ISO rottlerin inhibits the reaction [Serotonin results in increased expression of ACAT1 protein] CTD PMID:16157345 NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:53,979,813...54,008,855 		JBrowse link
G Agt angiotensinogen multiple interactions EXP rottlerin inhibits the reaction [AGT protein affects the localization of ELAVL1 protein] CTD PMID:19246637 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of AIF1 protein] CTD PMID:30366073 NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO rottlerin results in decreased phosphorylation of AKT1 protein
rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]		 CTD PMID:15177934 PMID:19393235 PMID:22902833 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of APP protein]] CTD PMID:20488202 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Atg7 autophagy related 7 multiple interactions
increases expression		 ISO 3-methyladenine inhibits the reaction [rottlerin results in increased expression of ATG7 protein] CTD PMID:22902833 NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form]]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form] CTD PMID:25895139 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO rottlerin inhibits the reaction [Doxorubicin results in increased activity of BAK1 protein] CTD PMID:15917298 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of BAX protein]; rottlerin inhibits the reaction [Cisplatin affects the localization of BAX protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]
rottlerin results in increased expression of BAX protein		 CTD PMID:21633170 PMID:22902833 PMID:25895139 PMID:30366073 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO rottlerin results in decreased expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2 protein]; rottlerin inhibits the reaction [Cocaine results in decreased expression of BCL2 protein]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]; rottlerin promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]		 CTD PMID:22902833 PMID:25895139 PMID:30366073 PMID:30393195 PMID:35995259 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions		 ISO rottlerin results in decreased expression of BCL2L1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2L1 protein]; rottlerin inhibits the reaction [Cocaine results in decreased expression of BCL2L1 protein]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein]		 CTD PMID:22902833 PMID:25895139 PMID:30366073 PMID:30393195 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 ISO 3-methyladenine inhibits the reaction [rottlerin results in increased expression of BECN1 protein] CTD PMID:22902833 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BIRC3 mRNA] CTD PMID:14527959 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions
increases activity
increases cleavage		 EXP
ISO		 rottlerin results in decreased activity of CASP3 protein
rottlerin inhibits the reaction [2-methylcyclopentadienyl manganese tricarbonyl results in increased activity of CASP3 protein]; rottlerin inhibits the reaction [Dieldrin results in increased activity of CASP3 protein]; rottlerin inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]
rottlerin results in increased activity of CASP3 protein
rottlerin inhibits the reaction [NSC606985 results in increased activity of CASP3 protein]; rottlerin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]
rottlerin results in increased cleavage of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased cleavage of CASP3 protein]; rottlerin inhibits the reaction [Cocaine results in increased cleavage of CASP3 protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]		 CTD PMID:11880503 PMID:12831855 PMID:19662097 PMID:21362627 PMID:22410117 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 multiple interactions ISO rottlerin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein] CTD PMID:21362627 NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage		 ISO rottlerin inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of CASP9 protein]; rottlerin inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased cleavage of CASP9 protein]
rottlerin results in increased cleavage of CASP9 protein		 CTD PMID:12626342 PMID:22902833 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [sorafenib co-treated with rottlerin] results in decreased expression of CCND1 protein CTD PMID:16959960 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO [sorafenib co-treated with rottlerin] results in decreased expression of CCND3 protein CTD PMID:16959960 NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Cd38 CD38 molecule multiple interactions ISO rottlerin inhibits the reaction [Tretinoin results in increased expression of CD38 mRNA]; rottlerin inhibits the reaction [Tretinoin results in increased expression of CD38 protein] CTD PMID:21393419 NCBI chr14:71,384,532...71,424,794
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression		 ISO Paclitaxel promotes the reaction [rottlerin results in increased expression of CDH1 protein] CTD PMID:35995259 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO [sorafenib co-treated with rottlerin] results in decreased expression of CDK4 protein CTD PMID:16959960 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO [sorafenib co-treated with rottlerin] results in decreased expression of CDK6 protein CTD PMID:16959960 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDKN1A protein] CTD PMID:15976015 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO rottlerin inhibits the reaction [NSC606985 results in decreased expression of CEBPA protein]; rottlerin inhibits the reaction [NSC606985 results in increased ubiquitination of CEBPA protein] CTD PMID:19662097 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cldn1 claudin 1 affects localization ISO rottlerin affects the localization of CLDN1 protein CTD PMID:19297429 NCBI chr11:87,926,376...87,941,533
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Cldn4 claudin 4 multiple interactions ISO rottlerin results in increased expression of and affects the localization of CLDN4 protein CTD PMID:19297429 NCBI chr12:27,388,160...27,389,958
Ensembl chr12:21,751,331...21,753,436 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO rottlerin inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein]; rottlerin inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA]; rottlerin inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 protein] CTD PMID:17030193 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO rottlerin results in decreased activity of CYP19A1 protein CTD PMID:15955695 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions ISO [rottlerin co-treated with Paclitaxel] results in decreased expression of CYP2J2 protein CTD PMID:35995259 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO
EXP		 rottlerin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]
rottlerin results in increased expression of DDIT3 protein
rottlerin inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]		 CTD PMID:17171638 PMID:22410117 PMID:27658547 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked increases expression ISO Rottlerin increases expression of DDX3X mRNA in liver RGD PMID:29203243 RGD:151356605 NCBI chr  X:12,152,346...12,165,983
Ensembl chr  X:9,479,532...9,493,168 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases phosphorylation EXP rottlerin results in decreased phosphorylation of EEF2 protein CTD PMID:12720544 NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO rottlerin inhibits the reaction [irinotecan metabolite results in increased phosphorylation of EGFR protein]; rottlerin inhibits the reaction [irinotecan results in increased phosphorylation of EGFR protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:15177934 PMID:15723263 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO rottlerin promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] CTD PMID:19771169 NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO
EXP		 rottlerin inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; rottlerin promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]
rottlerin inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]		 CTD PMID:12720544 PMID:19771169 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions EXP rottlerin inhibits the reaction [AGT protein affects the localization of ELAVL1 protein] CTD PMID:19246637 NCBI chr12:7,441,699...7,482,625
Ensembl chr12:2,645,061...2,684,784 		JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO rottlerin inhibits the reaction [PRKCD protein results in increased phosphorylation of FGF1 protein] CTD PMID:15574884 NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO rottlerin inhibits the reaction [FGF2 protein results in increased activity of RUNX2 protein]; rottlerin inhibits the reaction [FGF2 protein results in increased expression of RUNX2 mRNA] CTD PMID:12403780 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of FOS protein] CTD PMID:20599481 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO
EXP		 rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [Plant Extracts results in increased expression of GCLC protein]
rottlerin inhibits the reaction [naringin results in increased expression of GCLC protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]]; rottlerin affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]; rottlerin inhibits the reaction [Exenatide results in increased expression of GCLC protein]; rottlerin promotes the reaction [Cocaine results in increased expression of GCLC mRNA]; rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]		 CTD PMID:24211276 PMID:25773745 PMID:25895139 PMID:27939242 PMID:30393195 More... NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA]]; rottlerin affects the reaction [Dextromethorphan affects the expression of GCLM mRNA]; rottlerin promotes the reaction [Cocaine results in increased expression of GCLM mRNA]; rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA] CTD PMID:25895139 PMID:30393195 PMID:34740715 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions
increases expression
affects response to substance		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [rottlerin results in increased expression of GDF15 protein]; SB 203580 inhibits the reaction [rottlerin results in increased expression of GDF15 protein]
rottlerin results in increased expression of GDF15 mRNA; rottlerin results in increased expression of GDF15 protein
GDF15 affects the susceptibility to rottlerin		 CTD PMID:22410117 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO		 rottlerin inhibits the reaction [Acrolein results in increased secretion of GPT protein]; rottlerin inhibits the reaction [allyl alcohol results in increased secretion of GPT protein]
rottlerin inhibits the reaction [Cocaine results in increased activity of GPT protein]		 CTD PMID:12755590 PMID:30393195 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions ISO rottlerin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]] CTD PMID:34740715 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grp gastrin releasing peptide multiple interactions ISO rottlerin promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates] CTD PMID:18313772 NCBI chr18:61,658,655...61,672,037
Ensembl chr18:59,388,274...59,402,061 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha decreases expression
multiple interactions		 EXP rottlerin results in decreased expression of GSK3A protein
[Cadmium co-treated with rottlerin] results in decreased expression of GSK3A protein		 CTD PMID:27658547 NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases expression		 EXP [Cadmium co-treated with rottlerin] results in decreased expression of GSK3B protein; rottlerin inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]
rottlerin results in decreased expression of GSK3B protein		 CTD PMID:27658547 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO rottlerin results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP		 rottlerin inhibits the reaction [2-butenal results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [2-butenal results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Plant Extracts results in increased expression of HMOX1 protein]
rottlerin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Exenatide results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [puerarin results in increased expression of HMOX1 protein]
rottlerin inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [naringin results in increased expression of HMOX1 protein]		 CTD PMID:17535857 PMID:18048804 PMID:18357586 PMID:20060010 PMID:21238556 More... NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions ISO rottlerin inhibits the reaction [NSC606985 results in decreased expression of HNRNPK protein] CTD PMID:19747914 NCBI chr17:6,269,302...6,280,429
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO rottlerin results in increased expression of HSPA5 protein CTD PMID:22410117 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A mRNA]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A protein] CTD PMID:30366073 NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Ifng interferon gamma multiple interactions ISO rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IFNG protein] CTD PMID:30366073 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO rottlerin promotes the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:16330529 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO rottlerin inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]] CTD PMID:16241859 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IL6 protein]
rottlerin results in increased expression of IL6 protein		 CTD PMID:30366073 PMID:37722575 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression EXP rottlerin results in decreased expression of IRS2 protein CTD PMID:18308779 NCBI chr16:85,190,310...85,214,543
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of JUN protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of JUN protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of JUN protein] CTD PMID:18628248 PMID:20599481 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions EXP rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of LDLR protein]] CTD PMID:20488202 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases phosphorylation ISO rottlerin results in decreased phosphorylation of MAP2K1 protein CTD PMID:15949478 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions		 ISO
EXP		 rottlerin results in decreased phosphorylation of MAPK1 protein
[Sorafenib co-treated with rottlerin] results in decreased phosphorylation of MAPK1 protein; rottlerin inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK1 protein]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK1 protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]		 CTD PMID:12720544 PMID:14975926 PMID:15177934 PMID:16959960 PMID:17030193 More... NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases phosphorylation ISO rottlerin results in decreased phosphorylation of MAPK14 protein CTD PMID:15949478 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO
EXP		 [Sorafenib co-treated with rottlerin] results in decreased phosphorylation of MAPK3 protein; rottlerin inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK3 protein]; rottlerin inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK3 protein]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK3 protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
rottlerin results in decreased phosphorylation of MAPK3 protein
rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]		 CTD PMID:12720544 PMID:14975926 PMID:15177934 PMID:16959960 PMID:17030193 More... NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO rottlerin inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK8 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK8 protein] CTD PMID:15917298 PMID:20599481 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein] CTD PMID:20599481 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 decreases activity ISO rottlerin results in decreased activity of MAPKAPK2 protein CTD PMID:10998351 NCBI chr13:45,066,027...45,112,326
Ensembl chr13:42,513,762...42,560,457 		JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 decreases activity ISO rottlerin results in decreased activity of MAPKAPK5 protein CTD PMID:10998351 NCBI chr12:40,654,220...40,673,740
Ensembl chr12:34,994,092...35,013,052 		JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate multiple interactions ISO rottlerin inhibits the reaction [sodium arsenate results in increased phosphorylation of MARCKS protein] CTD PMID:11796722 NCBI chr20:42,240,185...42,245,882
Ensembl chr20:40,685,315...40,691,012 		JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions
increases expression		 ISO rottlerin inhibits the reaction [MIF protein results in increased expression of MMP2 protein]
rottlerin results in increased expression of MIF protein		 CTD PMID:16872482 PMID:37722575 NCBI chr20:12,767,138...12,791,222
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504 		JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions ISO rottlerin inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA] CTD PMID:16571779 NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:4,581,785...4,599,611 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO rottlerin inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA] CTD PMID:16571779 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO rottlerin inhibits the reaction [MIF protein results in increased expression of MMP2 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA] CTD PMID:16872482 PMID:20599481 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO rottlerin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA] CTD PMID:15557194 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation		 ISO rottlerin inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]
rottlerin results in decreased phosphorylation of MTOR protein		 CTD PMID:19771169 PMID:22902833 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased phosphorylation of and affects the localization of NCF1 protein] CTD PMID:30366073 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO rottlerin inhibits the reaction [Paraquat affects the localization of NCF2 protein] CTD PMID:17662968 NCBI chr13:67,505,492...67,536,015
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO
EXP		 rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Acrolein affects the localization of NFE2L2 protein]; rottlerin inhibits the reaction [Cadmium Chloride affects the localization of NFE2L2 protein]
rottlerin inhibits the reaction [naringin affects the localization of NFE2L2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]]; [rottlerin co-treated with Dextromethorphan] results in increased activity of and affects the localization of NFE2L2 protein; rottlerin promotes the reaction [Cocaine results in increased activity of and affects the localization of NFE2L2 protein]; rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]		 CTD PMID:18048804 PMID:21787730 PMID:24211276 PMID:25773745 PMID:25895139 More... NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO rottlerin inhibits the reaction [NGF results in increased phosphorylation of TRPV1 protein] CTD PMID:16319926 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP rottlerin inhibits the reaction [Paraquat results in increased expression of NOX1 mRNA]; rottlerin inhibits the reaction [Paraquat results in increased expression of NOX1 protein] CTD PMID:23827392 NCBI chr  X:101,572,338...101,625,571
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO rottlerin inhibits the reaction [Cadmium Chloride results in increased expression of NQO1 mRNA]; rottlerin inhibits the reaction [Cadmium Chloride results in increased expression of NQO1 protein]; rottlerin inhibits the reaction [Plant Extracts results in increased expression of NQO1 protein] CTD PMID:21787730 PMID:30626086 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nts neurotensin multiple interactions
increases activity		 ISO rottlerin affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
rottlerin results in increased activity of NTS protein		 CTD PMID:15177934 PMID:18313772 NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:37,564,533...37,574,423 		JBrowse link
G Ocln occludin affects localization ISO rottlerin affects the localization of OCLN protein modified form CTD PMID:19297429 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO rottlerin inhibits the reaction [PRL protein results in increased activity of ODC1 protein] CTD PMID:16520895 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G P2ry1 purinergic receptor P2Y1 multiple interactions EXP rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]] CTD PMID:17620283 NCBI chr 2:147,391,661...147,397,870
Ensembl chr 2:145,241,849...145,248,457 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO
EXP		 rottlerin results in increased cleavage of PARP1 protein
rottlerin inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]
[rottlerin co-treated with Paclitaxel] results in increased cleavage of PARP1 protein		 CTD PMID:22902833 PMID:27658547 PMID:35995259 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pld1 phospholipase D1 multiple interactions ISO rottlerin inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]] CTD PMID:17640750 NCBI chr 2:112,777,820...112,975,857
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Plscr1 phospholipid scramblase 1 multiple interactions ISO rottlerin inhibits the reaction [IFNA2 protein results in increased expression of PLSCR1 mRNA]; rottlerin inhibits the reaction [IFNA2 protein results in increased expression of PLSCR1 protein] CTD PMID:16260419 NCBI chr 8:101,662,512...101,684,474
Ensembl chr 8:92,784,356...92,804,692 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO rottlerin inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein] CTD PMID:17030193 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO rottlerin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 mRNA]; rottlerin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein] CTD PMID:11796722 NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions
decreases activity
decreases phosphorylation
decreases response to substance		 ISO
EXP		 [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]]; rottlerin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [IFNA2 protein results in increased phosphorylation of and results in increased activity of PRKCD protein]; rottlerin inhibits the reaction [NSC606985 results in increased activity of and results in increased cleavage of PRKCD protein]
[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased activity of TH protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of DAT protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of TH protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in increased metabolism of Dopamine]; [rottlerin results in decreased activity of PRKCD protein] which results in decreased susceptibility to Methamphetamine; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; rottlerin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; rottlerin inhibits the reaction [Dextromethorphan results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [p-Chloroamphetamine results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [PRKCD protein results in increased phosphorylation of FGF1 protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of and results in increased cleavage of PRKCD protein]
[rottlerin results in decreased activity of PRKCD protein] which results in decreased susceptibility to 2-methylcyclopentadienyl manganese tricarbonyl; rottlerin inhibits the reaction [2-methylcyclopentadienyl manganese tricarbonyl results in increased cleavage of and results in increased activity of PRKCD protein]; rottlerin inhibits the reaction [Cadmium results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [manganese chloride results in increased activity of PRKCD protein]; rottlerin inhibits the reaction [naringin results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of APP protein]]; rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of LDLR protein]]; rottlerin inhibits the reaction [sodium arsenite results in increased phosphorylation of PRKCD protein]
rottlerin results in decreased phosphorylation of PRKCD protein
PRKCD protein results in decreased susceptibility to rottlerin		 CTD PMID:11880503 PMID:12720544 PMID:15574884 PMID:15681813 PMID:15949478 More... NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkcq protein kinase C, theta decreases activity ISO rottlerin results in decreased activity of PRKCQ protein CTD PMID:15691325 NCBI chr17:72,156,215...72,288,508
Ensembl chr17:67,246,394...67,378,704 		JBrowse link
G Prl prolactin multiple interactions ISO rottlerin inhibits the reaction [PRL protein results in increased activity of ODC1 protein] CTD PMID:16520895 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO rottlerin inhibits the reaction [Acrolein results in increased expression of PTGS2 mRNA]; rottlerin inhibits the reaction [Acrolein results in increased expression of PTGS2 protein]; rottlerin inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein]; rottlerin inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]
rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of PTGS2 protein]		 CTD PMID:17363696 PMID:17640750 PMID:19084589 PMID:30366073 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation ISO rottlerin results in decreased phosphorylation of RAF1 protein CTD PMID:15949478 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO rottlerin results in decreased phosphorylation of RB1 protein CTD PMID:15949478 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases activity		 EXP rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]
rottlerin results in decreased activity of RPS6KB1 protein		 CTD PMID:12720544 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 multiple interactions
decreases activity		 EXP rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]
rottlerin results in decreased activity of RPS6KB2 protein		 CTD PMID:12720544 NCBI chr 1:210,880,824...210,887,556
Ensembl chr 1:201,451,265...201,458,078 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO rottlerin inhibits the reaction [FGF2 protein results in increased activity of RUNX2 protein]; rottlerin inhibits the reaction [FGF2 protein results in increased expression of RUNX2 mRNA] CTD PMID:12403780 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions ISO [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein] CTD PMID:22512859 NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of DAT protein] CTD PMID:22512859 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression
multiple interactions		 ISO rottlerin results in decreased expression of SNAI1 protein
rottlerin promotes the reaction [Paclitaxel results in decreased expression of SNAI1 protein]		 CTD PMID:35995259 NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 mRNA]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 protein] CTD PMID:21705328 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sts steroid sulfatase multiple interactions ISO rottlerin inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:46,102,524...46,110,868
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
G Tfap2a transcription factor AP-2 alpha multiple interactions ISO rottlerin inhibits the reaction [TFAP2A protein binds to ULBP1 promoter] CTD PMID:21499124 NCBI chr17:24,230,064...24,253,219
Ensembl chr17:24,024,432...24,047,507 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]] CTD PMID:22643241 NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO rottlerin inhibits the reaction [irinotecan metabolite results in increased secretion of TGFA protein]; rottlerin inhibits the reaction [irinotecan results in increased secretion of TGFA protein] CTD PMID:15723263 NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP
ISO		 rottlerin inhibits the reaction [manganese chloride results in decreased activity of TH protein]
[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased activity of TH protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of TH protein]		 CTD PMID:21310168 PMID:22512859 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tjp1 tight junction protein 1 affects localization ISO rottlerin affects the localization of TJP1 protein CTD PMID:19297429 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO rottlerin inhibits the reaction [NGF results in increased phosphorylation of TRPV1 protein] CTD PMID:16319926 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Tyr tyrosinase decreases expression ISO rottlerin results in decreased expression of TYR mRNA; rottlerin results in decreased expression of TYR protein CTD PMID:21071833 NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Ulbp1 UL16 binding protein 1 multiple interactions
increases expression		 ISO rottlerin inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]
rottlerin results in increased expression of ULBP1 mRNA		 CTD PMID:21499124 PMID:21951556 NCBI chr 1:3,506,106...3,527,982 JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO rottlerin inhibits the reaction [VEGFA protein results in increased abundance of phosphatidylbutanol] CTD PMID:14704231 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin decreases expression
multiple interactions		 ISO rottlerin results in decreased expression of VIM protein
rottlerin promotes the reaction [Paclitaxel results in decreased expression of VIM protein]		 CTD PMID:35995259 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO rottlerin results in decreased expression of XIAP protein CTD PMID:22902833 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      biological role 19878
        biochemical role 19586
          metabolite 19573
            rottlerin 115
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            organic molecule 19735
                              organic cyclic compound 19528
                                organic heterocyclic compound 18895
                                  oxacycle 17921
                                    benzopyran 11992
                                      1-benzopyran 11746
                                        chromenes 4440
                                          chromenol 115
                                            rottlerin 115
paths to the root