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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(S)-ropivacaine
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Accession:CHEBI:8890 term browser browse the term
Definition:A piperidinecarboxamide-based amide-type local anaesthetic (amide caine) in which (S)-N-propylpipecolic acid and 2,6-dimethylaniline are combined to form the amide bond.
Synonyms:exact_synonym: (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide
 related_synonym: (-)-1-propyl-2',6'-dimethyl-2-piperidylcarboxyanilide;   (-)-1-propyl-2',6'-pipecoloxylidide;   (S)-(-)-1-propyl-2',6'-pipecoloxylidide;   Formula=C17H26N2O;   InChI=1S/C17H26N2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20)/t15-/m0/s1;   InChIKey=ZKMNUMMKYBVTFN-HNNXBMFYSA-N;   L-N-n-propylpipecolic acid-2,6-xylidide;   SMILES=CCCN1CCCC[C@H]1C(=O)Nc1c(C)cccc1C;   ropivacaina;   ropivacaine;   ropivacainum
 alt_id: CHEBI:718203
 xref: CAS:84057-95-4;   DrugBank:DB00296;   Drug_Central:2403;   KEGG:C07532;   KEGG:D08490;   LINCS:LSM-5619
 xref_mesh: MESH:C037663
 xref: PMID:19586686;   Patent:WO8500599;   Reaxys:5421606;   Wikipedia:Ropivacaine


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(S)-ropivacaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Ropivacaine results in increased expression of AIFM1 protein CTD PMID:28079261 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO Ropivacaine results in decreased phosphorylation of AKT1 protein CTD PMID:36193553 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP
ISO		 Ropivacaine results in increased expression of BAX mRNA; Ropivacaine results in increased expression of BAX protein
pifithrin inhibits the reaction [Ropivacaine results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of BAX protein]		 CTD PMID:34091999 PMID:36193553 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases response to substance
multiple interactions
decreases expression		 ISO
EXP		 BCL2 protein results in decreased susceptibility to Ropivacaine
BCL2 protein inhibits the reaction [Ropivacaine results in increased cleavage of CASP3 protein]; BCL2 protein inhibits the reaction [Ropivacaine results in increased cleavage of PARP1 protein]
pifithrin inhibits the reaction [Ropivacaine results in decreased expression of BCL2 mRNA]; pifithrin inhibits the reaction [Ropivacaine results in decreased expression of BCL2 protein]
Ropivacaine results in decreased expression of BCL2 mRNA; Ropivacaine results in decreased expression of BCL2 protein		 CTD PMID:15538973 PMID:34091999 PMID:36193553 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions		 ISO Ropivacaine results in increased expression of BECN1 protein
Ropivacaine inhibits the reaction [3-methyladenine results in decreased expression of BECN1 protein]		 CTD PMID:36193553 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp1 caspase 1 multiple interactions
increases cleavage		 ISO Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of CASP1 protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of CASP1 protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of CASP1 protein]] CTD PMID:36858639 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 increases cleavage
decreases expression
multiple interactions
increases expression		 ISO
EXP		 Ropivacaine results in increased cleavage of CASP3 protein
Ropivacaine results in decreased expression of CASP3 protein
BCL2 protein inhibits the reaction [Ropivacaine results in increased cleavage of CASP3 protein]; CLU protein inhibits the reaction [Ropivacaine results in increased expression of CASP3 protein]
Ropivacaine results in increased expression of CASP3 mRNA
pifithrin inhibits the reaction [Ropivacaine results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of CASP3 mRNA]		 CTD PMID:15538973 PMID:20194319 PMID:34091999 PMID:36193553 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 decreases expression ISO Ropivacaine results in decreased expression of CASP9 protein CTD PMID:20194319 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Clu clusterin multiple interactions
decreases response to substance
decreases expression		 ISO CLU protein inhibits the reaction [Ropivacaine results in increased cleavage of PARP1 protein]; CLU protein inhibits the reaction [Ropivacaine results in increased expression of CASP3 protein]
CLU protein results in decreased susceptibility to Ropivacaine
Ropivacaine results in decreased expression of CLU protein		 CTD PMID:15538973 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Gsdmd gasdermin D increases cleavage
multiple interactions		 ISO Ropivacaine results in increased cleavage of GSDMD protein
Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein]]		 CTD PMID:36858639 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO Ropivacaine results in increased expression of HMOX1 protein
Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]]		 CTD PMID:36858639 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hrh1 histamine receptor H 1 affects binding ISO HRH1 protein binds to Ropivacaine CTD PMID:32061592 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Il18 interleukin 18 increases expression
multiple interactions		 ISO Ropivacaine results in increased expression of IL18 protein
Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL18 protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL18 protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL18 protein]]		 CTD PMID:36858639 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL1B protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL1B protein]] CTD PMID:36858639 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Ropivacaine inhibits the reaction [TNF protein results in increased expression of [ITGAM protein binds to ITGB2 protein]] CTD PMID:9336308 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO Ropivacaine inhibits the reaction [TNF protein results in increased expression of [ITGAM protein binds to ITGB2 protein]] CTD PMID:9336308 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 multiple interactions ISO Ropivacaine results in decreased activity of [KCNQ1 protein binds to KCNE1 protein] CTD PMID:16931984 NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 decreases activity
multiple interactions		 ISO Ropivacaine results in decreased activity of KCNQ1 protein
Ropivacaine results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]		 CTD PMID:16931984 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669 		JBrowse link
G Ldha lactate dehydrogenase A increases expression
multiple interactions		 ISO Ropivacaine results in increased expression of LDHA protein
Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of LDHA protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of LDHA protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of LDHA protein]]		 CTD PMID:36858639 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Ropivacaine results in decreased expression of MKI67 protein CTD PMID:36193553 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Ropivacaine results in decreased phosphorylation of MTOR protein CTD PMID:36193553 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of and results in increased localization of NFE2L2 protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of CASP1 protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL18 protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL1B protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of LDHA protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of NLRP3 protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]]; Ropivacaine results in increased expression of and results in increased localization of NFE2L2 protein CTD PMID:36858639 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression
multiple interactions		 ISO Ropivacaine results in increased expression of NLRP3 protein
Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of NLRP3 protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of NLRP3 protein]]		 CTD PMID:36858639 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
increases expression		 ISO Ropivacaine results in increased cleavage of PARP1 protein
BCL2 protein inhibits the reaction [Ropivacaine results in increased cleavage of PARP1 protein]; CLU protein inhibits the reaction [Ropivacaine results in increased cleavage of PARP1 protein]
Ropivacaine results in increased expression of PARP1 protein		 CTD PMID:15538973 PMID:28079261 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Sell selectin L multiple interactions ISO Ropivacaine inhibits the reaction [TNF protein results in increased cleavage of SELL protein] CTD PMID:9336308 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Slc25a29 solute carrier family 25 member 29 decreases activity
multiple interactions		 EXP Ropivacaine results in decreased activity of SLC25A29 protein
Emulsions inhibits the reaction [Ropivacaine results in decreased activity of SLC25A29 protein]		 CTD PMID:35135371 NCBI chr 6:127,742,027...127,752,915
Ensembl chr 6:127,742,033...127,752,940 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression		 ISO Ropivacaine inhibits the reaction [3-methyladenine results in increased expression of SQSTM1 protein]
Ropivacaine results in decreased expression of SQSTM1 protein		 CTD PMID:36193553 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO SULT1A1 protein results in increased sulfation of Ropivacaine metabolite CTD PMID:10460806 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 increases sulfation ISO SULT1E1 protein results in increased sulfation of Ropivacaine metabolite CTD PMID:10460806 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ropivacaine inhibits the reaction [TNF protein results in increased cleavage of SELL protein]; Ropivacaine inhibits the reaction [TNF protein results in increased expression of [ITGAM protein binds to ITGB2 protein]] CTD PMID:9336308 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 EXP pifithrin inhibits the reaction [Ropivacaine results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of TP53 protein]
Ropivacaine results in increased expression of TP53 mRNA; Ropivacaine results in increased expression of TP53 protein		 CTD PMID:34091999 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Ropivacaine results in decreased expression of VEGFA protein CTD PMID:36193553 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      application 19630
        pharmaceutical 19503
          drug 19471
            anaesthetic 11769
              local anaesthetic 7640
                (S)-ropivacaine 32
                  (S)-ropivacaine hydrochloride (anhydrous) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      carboacyl group 17675
                                        univalent carboacyl group 17675
                                          carbamoyl group 17524
                                            carboxamide 17547
                                              monocarboxylic acid amide 15660
                                                piperidinecarboxamide 67
                                                  ropivacaine 33
                                                    (S)-ropivacaine 32
                                                      (S)-ropivacaine hydrochloride (anhydrous) + 0
paths to the root