Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rofecoxib
go back to main search page
Accession:CHEBI:8887 term browser browse the term
Definition:A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke.
Synonyms:exact_synonym: 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
 related_synonym: 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone;   Ceoxx;   Formula=C17H14O4S;   InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3;   InChIKey=RZJQGNCSTQAWON-UHFFFAOYSA-N;   SMILES=CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccccc1;   Vioxx;   rofecoxibum
 xref: Beilstein:8269007;   CAS:162011-90-7;   DrugBank:DB00533;   Drug_Central:2397;   KEGG:C07590;   KEGG:D00568;   LINCS:LSM-2482
 xref_mesh: MESH:C116926
 xref: PMID:10859630;   PMID:11014111;   PMID:12069696;   PMID:16934051;   PMID:20162413;   PMID:28166217;   Reaxys:8269007;   Wikipedia:Rofecoxib



show annotations for term's descendants           Sort by:
 
rofecoxib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 affects expression ISO rofecoxib affects the expression of ADAMTS8 mRNA CTD PMID:17070997 NCBI chr 8:29,349,078...29,368,413
Ensembl chr 8:29,349,114...29,368,404
JBrowse link
G Adgrf1 adhesion G protein-coupled receptor F1 affects expression ISO rofecoxib affects the expression of ADGRF1 mRNA CTD PMID:17070997 NCBI chr 9:17,661,258...17,696,359
Ensembl chr 9:17,660,930...17,711,704
JBrowse link
G Adgrg6 adhesion G protein-coupled receptor G6 affects expression ISO rofecoxib affects the expression of ADGRG6 mRNA CTD PMID:17070997 NCBI chr 1:8,812,889...8,954,239
Ensembl chr 1:8,812,904...8,954,123
JBrowse link
G Afdn afadin, adherens junction formation factor affects expression ISO rofecoxib affects the expression of AFDN mRNA CTD PMID:17070997 NCBI chr 1:53,884,711...54,034,216
Ensembl chr 1:53,905,373...54,034,216
JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B affects expression ISO rofecoxib affects the expression of ALOX15B mRNA CTD PMID:17070997 NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812
JBrowse link
G Angpt1 angiopoietin 1 decreases expression ISO rofecoxib results in decreased expression of ANGPT1 mRNA CTD PMID:17070997 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
JBrowse link
G Angptl1 angiopoietin-like 1 decreases expression ISO rofecoxib results in decreased expression of ANGPTL1 mRNA CTD PMID:17070997 NCBI chr13:68,963,198...68,969,742
Ensembl chr13:68,962,991...68,992,570
JBrowse link
G Anxa1 annexin A1 affects expression ISO rofecoxib affects the expression of ANXA1 mRNA CTD PMID:17070997 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Anxa3 annexin A3 increases expression ISO rofecoxib results in increased expression of ANXA3 mRNA CTD PMID:17070997 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
JBrowse link
G Anxa9 annexin A9 decreases expression ISO rofecoxib results in decreased expression of ANXA9 mRNA CTD PMID:17070997 NCBI chr 2:182,873,185...182,884,501
Ensembl chr 2:182,872,929...182,883,374
JBrowse link
G Aox1 aldehyde oxidase 1 decreases expression ISO rofecoxib results in decreased expression of AOX1 mRNA CTD PMID:17070997 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
JBrowse link
G Arhgap29 Rho GTPase activating protein 29 decreases expression ISO rofecoxib results in decreased expression of ARHGAP29 mRNA CTD PMID:17070997 NCBI chr 2:210,060,036...210,132,572
Ensembl chr 2:210,071,199...210,132,028
JBrowse link
G C3 complement C3 increases expression ISO rofecoxib results in increased expression of C3 mRNA CTD PMID:17070997 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 decreases expression ISO rofecoxib results in decreased expression of CACNA2D3 mRNA CTD PMID:17070997 NCBI chr16:4,098,439...4,912,498
Ensembl chr16:4,098,445...4,912,351
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP rofecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of CALCA protein] CTD PMID:16690336 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Cat catalase multiple interactions EXP rofecoxib inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein] CTD PMID:20043943 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO rofecoxib results in increased expression of CCL2 mRNA CTD PMID:17070997 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions
increases expression
ISO Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 protein]
rofecoxib results in increased expression of CCL20 mRNA; rofecoxib results in increased expression of CCL20 protein
CTD PMID:17667525 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression
multiple interactions
ISO rofecoxib results in increased expression of CCL3 mRNA; rofecoxib results in increased expression of CCL3 protein
Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL3 protein]
CTD PMID:17667525 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression
ISO Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 protein]
rofecoxib results in increased expression of CCL5 mRNA; rofecoxib results in increased expression of CCL5 protein
CTD PMID:17667525 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO rofecoxib inhibits the reaction [Carbon Tetrachloride results in increased expression of CCN2 protein] CTD PMID:17565644 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Cdh2 cadherin 2 affects expression ISO rofecoxib affects the expression of CDH2 mRNA CTD PMID:17070997 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdh3 cadherin 3 increases expression ISO rofecoxib results in increased expression of CDH3 mRNA CTD PMID:17070997 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
JBrowse link
G Cdsn corneodesmosin affects expression ISO rofecoxib affects the expression of CDSN mRNA CTD PMID:17070997 NCBI chr20:3,179,432...3,185,854
Ensembl chr20:3,179,438...3,184,250
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 affects expression ISO rofecoxib affects the expression of CEACAM1 mRNA CTD PMID:17070997 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Clu clusterin increases expression ISO rofecoxib results in increased expression of CLU mRNA CTD PMID:17070997 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Col14a1 collagen type XIV alpha 1 chain decreases expression ISO rofecoxib results in decreased expression of COL14A1 mRNA CTD PMID:17070997 NCBI chr 7:86,722,093...86,937,215
Ensembl chr 7:86,722,094...86,937,214
JBrowse link
G Colec12 collectin sub-family member 12 decreases expression ISO rofecoxib results in decreased expression of COLEC12 mRNA CTD PMID:17070997 NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618
JBrowse link
G Crisp3 cysteine-rich secretory protein 3 increases expression ISO rofecoxib results in increased expression of CRISP3 mRNA CTD PMID:17070997 NCBI chr 9:20,432,051...20,472,663
Ensembl chr 9:20,450,908...20,472,658
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 affects expression ISO rofecoxib affects the expression of CX3CL1 mRNA CTD PMID:17070997 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 affects expression ISO rofecoxib affects the expression of CXCL1 mRNA CTD PMID:17070997 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects expression ISO rofecoxib affects the expression of CXCL1 mRNA CTD PMID:17070997 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of tizanidine]
rofecoxib results in decreased activity of CYP1A2 protein
CTD PMID:15834531 PMID:16934051 PMID:18816299 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Defb5 defensin beta 5 increases expression ISO rofecoxib results in increased expression of DEFB4 mRNA CTD PMID:17070997 NCBI chr16:70,613,200...70,615,360
Ensembl chr16:70,613,146...70,615,467
JBrowse link
G Dsc1 desmocollin 1 affects expression ISO rofecoxib affects the expression of DSC1 mRNA CTD PMID:17070997 NCBI chr18:11,499,936...11,556,801
Ensembl chr18:11,502,003...11,528,494
JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO rofecoxib inhibits the reaction [IL1B results in increased activity of EDNRB] CTD PMID:12126971 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Epha3 Eph receptor A3 decreases expression ISO rofecoxib results in decreased expression of EPHA3 mRNA CTD PMID:17070997 NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900
JBrowse link
G Ephb6 Eph receptor B6 decreases expression ISO rofecoxib results in decreased expression of EPHB6 mRNA CTD PMID:17070997 NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230
JBrowse link
G Etv5 ETS variant transcription factor 5 decreases expression ISO rofecoxib results in decreased expression of ETV5 mRNA CTD PMID:17070997 NCBI chr11:78,608,618...78,666,221
Ensembl chr11:78,608,710...78,666,215
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO rofecoxib results in decreased expression of FABP4 mRNA CTD PMID:17070997 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Faf1 Fas associated factor 1 affects expression ISO rofecoxib affects the expression of FAF1 mRNA CTD PMID:17070997 NCBI chr 5:124,426,032...124,790,014
Ensembl chr 5:124,426,062...124,789,977
JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 decreases expression ISO rofecoxib results in decreased expression of FAIM2 mRNA CTD PMID:17070997 NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168
JBrowse link
G Flnb filamin B increases expression ISO rofecoxib results in increased expression of FLNB mRNA CTD PMID:17070997 NCBI chr15:16,961,999...17,095,059
Ensembl chr15:16,962,003...17,095,006
JBrowse link
G Foxd1 forkhead box D1 decreases expression ISO rofecoxib results in decreased expression of FOXD1 mRNA CTD PMID:17070997 NCBI chr 2:29,702,558...29,704,978
Ensembl chr 2:29,702,558...29,704,978
JBrowse link
G Frzb frizzled-related protein affects expression ISO rofecoxib affects the expression of FRZB mRNA CTD PMID:17070997 NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208
JBrowse link
G Gata3 GATA binding protein 3 decreases expression ISO rofecoxib results in decreased expression of GATA3 mRNA CTD PMID:17070997 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO rofecoxib results in decreased expression of HGF mRNA CTD PMID:17070997 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase decreases expression ISO rofecoxib results in decreased expression of HPGD mRNA CTD PMID:17070997 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
JBrowse link
G Il1a interleukin 1 alpha affects expression
decreases expression
ISO rofecoxib affects the expression of IL1A mRNA
rofecoxib results in decreased expression of IL1A mRNA
CTD PMID:17070997 PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; rofecoxib inhibits the reaction [IL1B results in increased activity of EDNRB]; rofecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; rofecoxib promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; tert-Butylhydroperoxide inhibits the reaction [rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
rofecoxib promotes the reaction [Acetic Acid results in increased expression of IL1B protein]
CTD PMID:11376495 PMID:12126971 PMID:14762100 PMID:15705740 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression ISO rofecoxib results in increased expression of IL1RN mRNA CTD PMID:17070997 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il6 interleukin 6 increases expression ISO rofecoxib results in increased expression of IL6 mRNA; rofecoxib results in increased expression of IL6 protein CTD PMID:17070997 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Insm1 INSM transcriptional repressor 1 decreases expression ISO rofecoxib results in decreased expression of INSM1 mRNA CTD PMID:17070997 NCBI chr 3:133,639,790...133,642,963
Ensembl chr 3:133,639,580...133,643,003
JBrowse link
G Itgbl1 integrin subunit beta like 1 affects expression ISO rofecoxib affects the expression of ITGBL1 mRNA CTD PMID:17070997 NCBI chr15:100,780,184...101,041,734
Ensembl chr15:100,780,184...101,041,733
JBrowse link
G Klf12 Kruppel-like factor 12 affects expression ISO rofecoxib affects the expression of KLF12 mRNA CTD PMID:17070997 NCBI chr15:76,628,778...77,062,000
Ensembl chr15:76,637,654...77,062,056
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP rofecoxib inhibits the reaction [Dimethoate results in increased expression of LHB protein] CTD PMID:19579042 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lifr LIF receptor subunit alpha decreases expression ISO rofecoxib results in decreased expression of LIFR mRNA CTD PMID:17070997 NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699
JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha increases expression ISO rofecoxib results in increased expression of LMX1A mRNA CTD PMID:17070997 NCBI chr13:79,834,614...79,978,253
Ensembl chr13:79,835,019...79,978,253
JBrowse link
G Mal mal, T-cell differentiation protein increases expression ISO rofecoxib results in increased expression of MAL mRNA CTD PMID:17070997 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 decreases expression ISO rofecoxib results in decreased expression of MAPRE2 mRNA CTD PMID:17070997 NCBI chr18:15,028,675...15,169,553
Ensembl chr18:15,029,041...15,168,044
JBrowse link
G Mbtd1 mbt domain containing 1 decreases expression ISO rofecoxib results in decreased expression of MBTD1 mRNA CTD PMID:17070997 NCBI chr10:78,839,140...78,895,413
Ensembl chr10:78,839,036...78,893,720
JBrowse link
G Mef2c myocyte enhancer factor 2C affects expression ISO rofecoxib affects the expression of MEF2C mRNA CTD PMID:17070997 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
JBrowse link
G Meox2 mesenchyme homeobox 2 decreases expression ISO rofecoxib results in decreased expression of MEOX2 mRNA CTD PMID:17070997 NCBI chr 6:53,856,760...53,917,467
Ensembl chr 6:53,856,758...53,917,467
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO rofecoxib results in increased expression of MMP1 mRNA CTD PMID:16580899 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO rofecoxib results in increased expression of MMP3 mRNA CTD PMID:16580899 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO rofecoxib affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
JBrowse link
G Mta2 metastasis associated 1 family, member 2 decreases expression ISO rofecoxib results in decreased expression of MTA2 mRNA CTD PMID:17070997 NCBI chr 1:205,838,181...205,846,903
Ensembl chr 1:205,837,964...205,846,946
JBrowse link
G Naaladl2 N-acetylated alpha-linked acidic dipeptidase-like 2 decreases expression ISO rofecoxib results in decreased expression of NAALADL2 mRNA CTD PMID:17070997 NCBI chr 2:106,639,146...107,992,218
Ensembl chr 2:106,645,608...107,991,689
JBrowse link
G Nfasc neurofascin decreases expression ISO rofecoxib results in decreased expression of NFASC mRNA CTD PMID:17070997 NCBI chr13:43,997,223...44,183,863
Ensembl chr13:43,997,224...44,183,880
JBrowse link
G Ngf nerve growth factor multiple interactions EXP rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NGF protein] CTD PMID:16879691 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nos1 nitric oxide synthase 1 affects expression ISO rofecoxib affects the expression of NOS1 mRNA CTD PMID:17070997 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein] CTD PMID:16879691 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP rofecoxib inhibits the reaction [Lead results in increased expression of NOX1 mRNA]; rofecoxib inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA] CTD PMID:23415682 PMID:25596430 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Npas3 neuronal PAS domain protein 3 increases expression ISO rofecoxib results in increased expression of NPAS3 mRNA CTD PMID:17070997 NCBI chr 6:70,702,773...71,527,928
Ensembl chr 6:70,703,170...71,524,884
JBrowse link
G Npr2 natriuretic peptide receptor 2 decreases expression ISO rofecoxib results in decreased expression of NPR2 mRNA CTD PMID:17070997 NCBI chr 5:57,883,171...57,901,590
Ensembl chr 5:57,883,171...57,901,580
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects expression ISO rofecoxib affects the expression of NQO1 mRNA CTD PMID:17070997 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pi4ka phosphatidylinositol 4-kinase alpha decreases expression ISO rofecoxib results in decreased expression of PI4KA mRNA CTD PMID:17070997 NCBI chr11:83,609,136...83,726,876
Ensembl chr11:83,609,069...83,724,080
JBrowse link
G Pla2g2a phospholipase A2 group IIA affects expression ISO rofecoxib affects the expression of PLA2G2A mRNA CTD PMID:17070997 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO rofecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO rofecoxib results in increased expression of PLAT mRNA CTD PMID:16580899 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Pml PML nuclear body scaffold increases expression ISO rofecoxib results in increased expression of PML mRNA CTD PMID:17070997 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Postn periostin affects expression ISO rofecoxib affects the expression of POSTN mRNA CTD PMID:17070997 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
JBrowse link
G Prrx1 paired related homeobox 1 affects expression ISO rofecoxib affects the expression of PRRX1 mRNA CTD PMID:17070997 NCBI chr13:75,600,777...75,671,896
Ensembl chr13:75,601,706...75,670,866
JBrowse link
G Ptger3 prostaglandin E receptor 3 decreases expression ISO rofecoxib results in decreased expression of PTGER3 mRNA CTD PMID:17070997 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
JBrowse link
G Ptgis prostaglandin I2 synthase decreases expression ISO rofecoxib results in decreased expression of PTGIS mRNA CTD PMID:17175104 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity
decreases expression
ISO rofecoxib analog results in decreased activity of PTGS1 protein; rofecoxib results in decreased activity of PTGS1 protein
rofecoxib results in decreased expression of PTGS1 mRNA
CTD PMID:16141368 PMID:17175104 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases response to substance
multiple interactions
decreases activity
increases expression
decreases expression
ISO
EXP
PTGS2 promoter SNP results in increased susceptibility to rofecoxib
[rofecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; tert-Butylhydroperoxide inhibits the reaction [rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
rofecoxib results in increased expression of PTGS2 mRNA
PTGS2 inhibits the reaction [rofecoxib results in increased uptake of Hexoses]
rofecoxib results in decreased expression of PTGS2 mRNA
[rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Furosemide results in increased abundance of Prostaglandins]; [rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Hydrochlorothiazide results in increased abundance of Prostaglandins]; [rofecoxib results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [rofecoxib results in decreased activity of PTGS2 protein] which results in decreased susceptibility to Lipopolysaccharides; Dinoprostone results in decreased susceptibility to [rofecoxib results in decreased activity of PTGS2 protein]
CTD PMID:10594344 PMID:11245490 PMID:11321505 PMID:11703585 PMID:12110471 More... NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rasa1 RAS p21 protein activator 1 affects expression ISO rofecoxib affects the expression of RASA1 mRNA CTD PMID:17070997 NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854
JBrowse link
G Rnf144b ring finger protein 144B increases expression ISO rofecoxib results in increased expression of RNF144B mRNA CTD PMID:17070997 NCBI chr17:17,431,271...17,580,687
Ensembl chr17:17,432,786...17,562,760
JBrowse link
G Rorc RAR-related orphan receptor C decreases expression ISO rofecoxib results in decreased expression of RORC mRNA CTD PMID:17070997 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO rofecoxib results in increased expression of SCD mRNA CTD PMID:17070997 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N increases expression ISO rofecoxib results in increased expression of SERPINA3 mRNA CTD PMID:17070997 NCBI chr 6:123,323,632...123,331,166
Ensembl chr 6:123,323,629...123,332,433
JBrowse link
G Sh2d1a SH2 domain containing 1A decreases expression ISO rofecoxib results in decreased expression of SH2D1A mRNA CTD PMID:17070997 NCBI chr  X:121,373,693...121,401,923 JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO SLC2A1 inhibits the reaction [rofecoxib results in increased uptake of Hexoses] CTD PMID:16447059 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression
multiple interactions
ISO rofecoxib results in increased expression of SLC2A4 mRNA; rofecoxib results in increased expression of SLC2A4 protein
[rofecoxib results in increased expression of SLC2A4 protein] which results in increased uptake of Hexoses
CTD PMID:16447059 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO rofecoxib results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO rofecoxib results in increased expression of SOCS3 mRNA; rofecoxib results in increased expression of SOCS3 protein CTD PMID:17070997 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO rofecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO rofecoxib results in increased expression of SOD2 mRNA CTD PMID:17070997 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO rofecoxib results in increased expression of STAT3 mRNA CTD PMID:17070997 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tac1 tachykinin, precursor 1 increases expression ISO rofecoxib results in increased expression of TAC1 protein CTD PMID:16449370 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tead4 TEA domain transcription factor 4 increases expression ISO rofecoxib results in increased expression of TEAD4 mRNA CTD PMID:17070997 NCBI chr 4:161,474,122...161,572,837
Ensembl chr 4:161,497,851...161,572,323
JBrowse link
G Tfrc transferrin receptor affects expression ISO rofecoxib affects the expression of TFRC mRNA CTD PMID:17070997 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 decreases expression ISO rofecoxib results in decreased expression of TIMP3 mRNA CTD PMID:16580899 NCBI chr 7:17,520,827...17,571,871
Ensembl chr 7:17,521,919...17,571,839
JBrowse link
G Tmprss4 transmembrane serine protease 4 increases expression ISO rofecoxib results in increased expression of TMPRSS4 mRNA CTD PMID:17070997 NCBI chr 8:45,475,819...45,508,409
Ensembl chr 8:45,476,053...45,508,409
JBrowse link
G Tnc tenascin C increases expression ISO rofecoxib results in increased expression of TNC mRNA CTD PMID:17070997 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
rofecoxib promotes the reaction [Acetic Acid results in increased expression of TNF protein]
rofecoxib results in decreased expression of TNF protein
CTD PMID:11376495 PMID:17878525 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trim17 tripartite motif-containing 17 affects expression ISO rofecoxib affects the expression of TRIM17 mRNA CTD PMID:17070997 NCBI chr10:43,743,111...43,750,929
Ensembl chr10:43,740,604...43,750,919
JBrowse link
G Tspan2 tetraspanin 2 decreases expression ISO rofecoxib results in decreased expression of TSPAN2 mRNA CTD PMID:17070997 NCBI chr 2:190,177,717...190,234,994
Ensembl chr 2:190,177,741...190,219,660
JBrowse link
G Vcan versican decreases expression ISO rofecoxib results in decreased expression of VCAN mRNA CTD PMID:17070997 NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20024
      biological role 20023
        pharmacological role 19105
          analgesic 14647
            rofecoxib 110
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19894
                        carbon atom 19887
                          organic molecular entity 19887
                            organic group 18965
                              organic divalent group 18951
                                organodiyl group 18951
                                  carbonyl group 18903
                                    carbonyl compound 18903
                                      carboxylic ester 15957
                                        lactone 11299
                                          gamma-lactone 6815
                                            butenolide 6353
                                              rofecoxib 110
paths to the root