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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rofecoxib
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Accession:CHEBI:8887 term browser browse the term
Definition:A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke.
Synonyms:exact_synonym: 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
 related_synonym: 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone;   Ceoxx;   Formula=C17H14O4S;   InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3;   InChIKey=RZJQGNCSTQAWON-UHFFFAOYSA-N;   SMILES=CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccccc1;   Vioxx;   rofecoxibum
 xref: Beilstein:8269007;   CAS:162011-90-7;   DrugBank:DB00533;   Drug_Central:2397;   KEGG:C07590;   KEGG:D00568;   LINCS:LSM-2482
 xref_mesh: MESH:C116926
 xref: PMID:10859630;   PMID:11014111;   PMID:12069696;   PMID:16934051;   PMID:20162413;   PMID:28166217;   Reaxys:8269007;   Wikipedia:Rofecoxib


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rofecoxib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 affects expression ISO rofecoxib affects the expression of ADAMTS8 mRNA CTD PMID:17070997 NCBI chr 8:32,017,684...32,037,529
Ensembl chr 8:32,018,560...32,037,531
JBrowse link
G Adgrf1 adhesion G protein-coupled receptor F1 affects expression ISO rofecoxib affects the expression of ADGRF1 mRNA CTD PMID:17070997 NCBI chr 9:20,343,730...20,378,686 JBrowse link
G Adgrg6 adhesion G protein-coupled receptor G6 affects expression ISO rofecoxib affects the expression of ADGRG6 mRNA CTD PMID:17070997 NCBI chr 1:8,593,342...8,751,540
Ensembl chr 1:8,593,075...8,751,198
JBrowse link
G Afdn afadin, adherens junction formation factor affects expression ISO rofecoxib affects the expression of AFDN mRNA CTD PMID:17070997 NCBI chr 1:53,713,873...53,861,918
Ensembl chr 1:53,715,693...53,802,658
JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B affects expression ISO rofecoxib affects the expression of ALOX15B mRNA CTD PMID:17070997 NCBI chr10:55,773,748...55,783,489
Ensembl chr10:55,774,006...55,783,489
JBrowse link
G Angpt1 angiopoietin 1 decreases expression ISO rofecoxib results in decreased expression of ANGPT1 mRNA CTD PMID:17070997 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link
G Angptl1 angiopoietin-like 1 decreases expression ISO rofecoxib results in decreased expression of ANGPTL1 mRNA CTD PMID:17070997 NCBI chr13:74,456,487...74,463,031
Ensembl chr13:74,410,010...74,474,681
JBrowse link
G Anxa1 annexin A1 affects expression ISO rofecoxib affects the expression of ANXA1 mRNA CTD PMID:17070997 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Anxa3 annexin A3 increases expression ISO rofecoxib results in increased expression of ANXA3 mRNA CTD PMID:17070997 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
JBrowse link
G Anxa9 annexin A9 decreases expression ISO rofecoxib results in decreased expression of ANXA9 mRNA CTD PMID:17070997 NCBI chr 2:196,470,318...196,481,568
Ensembl chr 2:196,470,858...196,479,770
JBrowse link
G Aox1 aldehyde oxidase 1 decreases expression ISO rofecoxib results in decreased expression of AOX1 mRNA CTD PMID:17070997 NCBI chr 9:64,929,682...65,007,872
Ensembl chr 9:64,929,721...65,007,870
JBrowse link
G Arhgap29 Rho GTPase activating protein 29 decreases expression ISO rofecoxib results in decreased expression of ARHGAP29 mRNA CTD PMID:17070997 NCBI chr 2:225,552,075...225,613,349
Ensembl chr 2:225,552,148...225,613,359
JBrowse link
G C2cd4a C2 calcium-dependent domain containing 4A affects expression ISO rofecoxib affects the expression of NLF1 mRNA CTD PMID:17070997 NCBI chr 8:73,671,516...73,686,344
Ensembl chr 8:73,672,295...73,673,317
JBrowse link
G C3 complement C3 increases expression ISO rofecoxib results in increased expression of C3 mRNA CTD PMID:17070997 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 decreases expression ISO rofecoxib results in decreased expression of CACNA2D3 mRNA CTD PMID:17070997 NCBI chr16:4,871,348...5,795,825
Ensembl chr16:4,871,650...5,795,825
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP rofecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of CALCA protein] CTD PMID:16690336 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Cat catalase multiple interactions EXP rofecoxib inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein] CTD PMID:20043943 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO rofecoxib results in increased expression of CCL2 mRNA CTD PMID:17070997 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions
increases expression
ISO Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 protein]
rofecoxib results in increased expression of CCL20 mRNA; rofecoxib results in increased expression of CCL20 protein
CTD PMID:17667525 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression
multiple interactions
ISO rofecoxib results in increased expression of CCL3 mRNA; rofecoxib results in increased expression of CCL3 protein
Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL3 protein]
CTD PMID:17667525 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression
ISO Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 protein]
rofecoxib results in increased expression of CCL5 mRNA; rofecoxib results in increased expression of CCL5 protein
CTD PMID:17667525 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO rofecoxib inhibits the reaction [Carbon Tetrachloride results in increased expression of CCN2 protein] CTD PMID:17565644 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cdh2 cadherin 2 affects expression ISO rofecoxib affects the expression of CDH2 mRNA CTD PMID:17070997 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdh3 cadherin 3 increases expression ISO rofecoxib results in increased expression of CDH3 mRNA CTD PMID:17070997 NCBI chr19:38,668,957...38,719,801
Ensembl chr19:38,669,230...38,719,677
JBrowse link
G Cdsn corneodesmosin affects expression ISO rofecoxib affects the expression of CDSN mRNA CTD PMID:17070997 NCBI chr20:3,704,626...3,707,266 JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 affects expression ISO rofecoxib affects the expression of CEACAM1 mRNA CTD PMID:17070997 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Clu clusterin increases expression ISO rofecoxib results in increased expression of CLU mRNA CTD PMID:17070997 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Col14a1 collagen type XIV alpha 1 chain decreases expression ISO rofecoxib results in decreased expression of COL14A1 mRNA CTD PMID:17070997 NCBI chr 7:95,054,877...95,274,073
Ensembl chr 7:95,074,236...95,273,298
JBrowse link
G Colec12 collectin sub-family member 12 decreases expression ISO rofecoxib results in decreased expression of COLEC12 mRNA CTD PMID:17070997 NCBI chr18:867,048...1,054,047
Ensembl chr18:867,048...1,052,606
JBrowse link
G Crisp3 cysteine-rich secretory protein 3 increases expression ISO rofecoxib results in increased expression of CRISP3 mRNA CTD PMID:17070997 NCBI chr 9:24,047,405...24,088,066
Ensembl chr 9:24,066,303...24,088,064
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 affects expression ISO rofecoxib affects the expression of CX3CL1 mRNA CTD PMID:17070997 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 affects expression ISO rofecoxib affects the expression of CXCL1 mRNA CTD PMID:17070997 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects expression ISO rofecoxib affects the expression of CXCL1 mRNA CTD PMID:17070997 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of tizanidine]
rofecoxib results in decreased activity of CYP1A2 protein
CTD PMID:15834531 PMID:16934051 PMID:18816299 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Defb4 defensin beta 4 increases expression ISO rofecoxib results in increased expression of DEFB4 mRNA CTD PMID:17070997 NCBI chr16:75,634,598...75,637,789
Ensembl chr16:75,634,598...75,637,789
JBrowse link
G Dsc1 desmocollin 1 affects expression ISO rofecoxib affects the expression of DSC1 mRNA CTD PMID:17070997 NCBI chr18:11,877,918...11,906,828
Ensembl chr18:11,877,561...11,906,827
JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO rofecoxib inhibits the reaction [IL1B results in increased activity of EDNRB] CTD PMID:12126971 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Epha3 Eph receptor A3 decreases expression ISO rofecoxib results in decreased expression of EPHA3 mRNA CTD PMID:17070997 NCBI chr11:421,253...783,037
Ensembl chr11:421,135...782,954
JBrowse link
G Ephb6 Eph receptor B6 decreases expression ISO rofecoxib results in decreased expression of EPHB6 mRNA CTD PMID:17070997 NCBI chr 4:70,903,253...70,918,514
Ensembl chr 4:70,903,253...70,918,514
JBrowse link
G Etv5 ETS variant transcription factor 5 decreases expression ISO rofecoxib results in decreased expression of ETV5 mRNA CTD PMID:17070997 NCBI chr11:82,194,657...82,252,145
Ensembl chr11:82,194,657...82,252,139
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO rofecoxib results in decreased expression of FABP4 mRNA CTD PMID:17070997 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Faf1 Fas associated factor 1 affects expression ISO rofecoxib affects the expression of FAF1 mRNA CTD PMID:17070997 NCBI chr 5:129,370,767...129,738,393
Ensembl chr 5:129,448,879...129,738,252
JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 decreases expression ISO rofecoxib results in decreased expression of FAIM2 mRNA CTD PMID:17070997 NCBI chr 7:141,158,769...141,185,781
Ensembl chr 7:141,157,963...141,185,710
JBrowse link
G Flnb filamin B increases expression ISO rofecoxib results in increased expression of FLNB mRNA CTD PMID:17070997 NCBI chr15:18,750,152...18,883,019
Ensembl chr15:18,750,118...18,883,005
JBrowse link
G Foxd1 forkhead box D1 decreases expression ISO rofecoxib results in decreased expression of FOXD1 mRNA CTD PMID:17070997 NCBI chr 2:28,460,068...28,462,488
Ensembl chr 2:28,460,068...28,462,488
JBrowse link
G Frzb frizzled-related protein affects expression ISO rofecoxib affects the expression of FRZB mRNA CTD PMID:17070997 NCBI chr 3:67,635,604...67,668,772
Ensembl chr 3:67,635,607...67,668,772
JBrowse link
G Gata3 GATA binding protein 3 decreases expression ISO rofecoxib results in decreased expression of GATA3 mRNA CTD PMID:17070997 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO rofecoxib results in decreased expression of HGF mRNA CTD PMID:17070997 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase decreases expression ISO rofecoxib results in decreased expression of HPGD mRNA CTD PMID:17070997 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Il1a interleukin 1 alpha affects expression
decreases expression
ISO rofecoxib affects the expression of IL1A mRNA
rofecoxib results in decreased expression of IL1A mRNA
CTD PMID:17070997 PMID:32816093 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; rofecoxib inhibits the reaction [IL1B results in increased activity of EDNRB]; rofecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; rofecoxib promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; tert-Butylhydroperoxide inhibits the reaction [rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
rofecoxib promotes the reaction [Acetic Acid results in increased expression of IL1B protein]
CTD PMID:11376495 PMID:12126971 PMID:14762100 PMID:15705740 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression ISO rofecoxib results in increased expression of IL1RN mRNA CTD PMID:17070997 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il6 interleukin 6 increases expression ISO rofecoxib results in increased expression of IL6 mRNA; rofecoxib results in increased expression of IL6 protein CTD PMID:17070997 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insm1 INSM transcriptional repressor 1 decreases expression ISO rofecoxib results in decreased expression of INSM1 mRNA CTD PMID:17070997 NCBI chr 3:140,427,961...140,430,467 JBrowse link
G Itgbl1 integrin subunit beta like 1 affects expression ISO rofecoxib affects the expression of ITGBL1 mRNA CTD PMID:17070997 NCBI chr15:110,114,148...110,378,970
Ensembl chr15:110,114,148...110,378,969
JBrowse link
G Klf12 Kruppel-like factor 12 affects expression ISO rofecoxib affects the expression of KLF12 mRNA CTD PMID:17070997 NCBI chr15:84,316,986...84,748,549
Ensembl chr15:84,324,470...84,748,525
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP rofecoxib inhibits the reaction [Dimethoate results in increased expression of LHB protein] CTD PMID:19579042 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lifr LIF receptor subunit alpha decreases expression ISO rofecoxib results in decreased expression of LIFR mRNA CTD PMID:17070997 NCBI chr 2:56,424,910...56,489,346
Ensembl chr 2:56,426,367...56,489,415
JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha increases expression ISO rofecoxib results in increased expression of LMX1A mRNA CTD PMID:17070997 NCBI chr13:85,916,753...86,061,534
Ensembl chr13:85,918,252...86,061,176
JBrowse link
G LOC299277 similar to serine (or cysteine) peptidase inhibitor, clade A, member 3B increases expression ISO rofecoxib results in increased expression of SERPINA3 mRNA CTD PMID:17070997 NCBI chr 6:127,871,895...127,888,287
Ensembl chr 6:127,872,666...127,886,540
JBrowse link
G Mal mal, T-cell differentiation protein increases expression ISO rofecoxib results in increased expression of MAL mRNA CTD PMID:17070997 NCBI chr 3:120,209,647...120,233,655
Ensembl chr 3:120,209,647...120,233,655
JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 decreases expression ISO rofecoxib results in decreased expression of MAPRE2 mRNA CTD PMID:17070997 NCBI chr18:14,814,149...15,780,290 JBrowse link
G Mbtd1 mbt domain containing 1 decreases expression ISO rofecoxib results in decreased expression of MBTD1 mRNA CTD PMID:17070997 NCBI chr10:81,588,233...81,645,532
Ensembl chr10:81,592,114...81,642,663
JBrowse link
G Mef2c myocyte enhancer factor 2C affects expression ISO rofecoxib affects the expression of MEF2C mRNA CTD PMID:17070997 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Meox2 mesenchyme homeobox 2 decreases expression ISO rofecoxib results in decreased expression of MEOX2 mRNA CTD PMID:17070997 NCBI chr 6:56,625,768...56,689,195
Ensembl chr 6:56,625,650...56,689,238
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO rofecoxib results in increased expression of MMP1 mRNA CTD PMID:16580899 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO rofecoxib results in increased expression of MMP3 mRNA CTD PMID:16580899 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO rofecoxib affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841
JBrowse link
G Mta2 metastasis associated 1 family, member 2 decreases expression ISO rofecoxib results in decreased expression of MTA2 mRNA CTD PMID:17070997 NCBI chr 1:225,140,863...225,149,584
Ensembl chr 1:225,140,863...225,149,583
JBrowse link
G Naaladl2 N-acetylated alpha-linked acidic dipeptidase-like 2 decreases expression ISO rofecoxib results in decreased expression of NAALADL2 mRNA CTD PMID:17070997 NCBI chr 2:109,092,931...110,424,885 JBrowse link
G Nfasc neurofascin decreases expression ISO rofecoxib results in decreased expression of NFASC mRNA CTD PMID:17070997 NCBI chr13:49,335,407...49,522,474
Ensembl chr13:49,335,408...49,522,415
JBrowse link
G Ngf nerve growth factor multiple interactions EXP rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NGF protein] CTD PMID:16879691 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos1 nitric oxide synthase 1 affects expression ISO rofecoxib affects the expression of NOS1 mRNA CTD PMID:17070997 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein] CTD PMID:16879691 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP rofecoxib inhibits the reaction [Lead results in increased expression of NOX1 mRNA]; rofecoxib inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA] CTD PMID:23415682 PMID:25596430 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Npas3 neuronal PAS domain protein 3 increases expression ISO rofecoxib results in increased expression of NPAS3 mRNA CTD PMID:17070997 NCBI chr 6:74,081,995...74,913,025 JBrowse link
G Npr2 natriuretic peptide receptor 2 decreases expression ISO rofecoxib results in decreased expression of NPR2 mRNA CTD PMID:17070997 NCBI chr 5:59,128,186...59,147,321
Ensembl chr 5:59,128,315...59,147,255
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects expression ISO rofecoxib affects the expression of NQO1 mRNA CTD PMID:17070997 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pi4ka phosphatidylinositol 4-kinase alpha decreases expression ISO rofecoxib results in decreased expression of PI4KA mRNA CTD PMID:17070997 NCBI chr11:87,858,323...87,975,549
Ensembl chr11:87,858,453...87,973,422
JBrowse link
G Pla2g2a phospholipase A2 group IIA affects expression ISO rofecoxib affects the expression of PLA2G2A mRNA CTD PMID:17070997 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO rofecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO rofecoxib results in increased expression of PLAT mRNA CTD PMID:16580899 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Pml PML nuclear body scaffold increases expression ISO rofecoxib results in increased expression of PML mRNA CTD PMID:17070997 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Postn periostin affects expression ISO rofecoxib affects the expression of POSTN mRNA CTD PMID:17070997 NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087
JBrowse link
G Prrx1 paired related homeobox 1 affects expression ISO rofecoxib affects the expression of PRRX1 mRNA CTD PMID:17070997 NCBI chr13:81,147,038...81,215,559
Ensembl chr13:81,147,348...81,214,546
JBrowse link
G Ptger3 prostaglandin E receptor 3 decreases expression ISO rofecoxib results in decreased expression of PTGER3 mRNA CTD PMID:17070997 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
G Ptgis prostaglandin I2 synthase decreases expression ISO rofecoxib results in decreased expression of PTGIS mRNA CTD PMID:17175104 NCBI chr 3:163,950,746...163,986,129 JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity
decreases expression
ISO rofecoxib analog results in decreased activity of PTGS1 protein; rofecoxib results in decreased activity of PTGS1 protein
rofecoxib results in decreased expression of PTGS1 mRNA
CTD PMID:16141368 PMID:17175104 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases response to substance
multiple interactions
decreases expression
decreases activity
increases expression
ISO
EXP
PTGS2 promoter SNP results in increased susceptibility to rofecoxib
[rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Furosemide results in increased abundance of Prostaglandins]; [rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Hydrochlorothiazide results in increased abundance of Prostaglandins]; [rofecoxib results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [rofecoxib results in decreased activity of PTGS2 protein] which results in decreased susceptibility to Lipopolysaccharides; Dinoprostone results in decreased susceptibility to [rofecoxib results in decreased activity of PTGS2 protein]
rofecoxib results in decreased expression of PTGS2 mRNA
PTGS2 inhibits the reaction [rofecoxib results in increased uptake of Hexoses]
rofecoxib results in increased expression of PTGS2 mRNA
[rofecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; tert-Butylhydroperoxide inhibits the reaction [rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
CTD PMID:10594344 PMID:11245490 PMID:11321505 PMID:11703585 PMID:12110471 PMID:12417326 PMID:15705740 PMID:15718289 PMID:16249722 PMID:16447059 PMID:16678543 PMID:16944022 PMID:17070997 PMID:17164136 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rasa1 RAS p21 protein activator 1 affects expression ISO rofecoxib affects the expression of RASA1 mRNA CTD PMID:17070997 NCBI chr 2:13,617,021...13,696,531
Ensembl chr 2:13,616,822...13,696,426
JBrowse link
G Rnf144b ring finger protein 144B increases expression ISO rofecoxib results in increased expression of RNF144B mRNA CTD PMID:17070997 NCBI chr17:17,817,122...17,947,777
Ensembl chr17:17,817,100...17,947,777
JBrowse link
G Rorc RAR-related orphan receptor C decreases expression ISO rofecoxib results in decreased expression of RORC mRNA CTD PMID:17070997 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO rofecoxib results in increased expression of SCD mRNA CTD PMID:17070997 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sh2d1a SH2 domain containing 1A decreases expression ISO rofecoxib results in decreased expression of SH2D1A mRNA CTD PMID:17070997 NCBI chr  X:128,897,053...128,925,408
Ensembl chr  X:128,897,181...128,925,407
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO SLC2A1 inhibits the reaction [rofecoxib results in increased uptake of Hexoses] CTD PMID:16447059 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression
multiple interactions
ISO rofecoxib results in increased expression of SLC2A4 mRNA; rofecoxib results in increased expression of SLC2A4 protein
[rofecoxib results in increased expression of SLC2A4 protein] which results in increased uptake of Hexoses
CTD PMID:16447059 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO rofecoxib results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO rofecoxib results in increased expression of SOCS3 mRNA; rofecoxib results in increased expression of SOCS3 protein CTD PMID:17070997 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO rofecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO rofecoxib results in increased expression of SOD2 mRNA CTD PMID:17070997 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO rofecoxib results in increased expression of STAT3 mRNA CTD PMID:17070997 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tac1 tachykinin, precursor 1 increases expression ISO rofecoxib results in increased expression of TAC1 protein CTD PMID:16449370 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tead4 TEA domain transcription factor 4 increases expression ISO rofecoxib results in increased expression of TEAD4 mRNA CTD PMID:17070997 NCBI chr 4:161,542,566...161,619,848
Ensembl chr 4:161,540,130...161,587,222
JBrowse link
G Tfrc transferrin receptor affects expression ISO rofecoxib affects the expression of TFRC mRNA CTD PMID:17070997 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 decreases expression ISO rofecoxib results in decreased expression of TIMP3 mRNA CTD PMID:16580899 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Tmprss4 transmembrane serine protease 4 increases expression ISO rofecoxib results in increased expression of TMPRSS4 mRNA CTD PMID:17070997 NCBI chr 8:49,469,804...49,503,304
Ensembl chr 8:49,469,503...49,502,647
JBrowse link
G Tnc tenascin C increases expression ISO rofecoxib results in increased expression of TNC mRNA CTD PMID:17070997 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
rofecoxib promotes the reaction [Acetic Acid results in increased expression of TNF protein]
rofecoxib results in decreased expression of TNF protein
CTD PMID:11376495 PMID:17878525 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trim17 tripartite motif-containing 17 affects expression ISO rofecoxib affects the expression of TRIM17 mRNA CTD PMID:17070997 NCBI chr10:45,307,007...45,314,823
Ensembl chr10:45,297,937...45,314,837
JBrowse link
G Tspan2 tetraspanin 2 decreases expression ISO rofecoxib results in decreased expression of TSPAN2 mRNA CTD PMID:17070997 NCBI chr 2:205,160,405...205,202,766
Ensembl chr 2:205,160,405...205,202,764
JBrowse link
G Vcan versican decreases expression ISO rofecoxib results in decreased expression of VCAN mRNA CTD PMID:17070997 NCBI chr 2:18,490,102...18,587,340
Ensembl chr 2:18,490,102...18,565,842
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      biological role 19723
        pharmacological role 18833
          analgesic 13094
            rofecoxib 111
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic group 18603
                              organic divalent group 18594
                                organodiyl group 18594
                                  carbonyl group 18507
                                    carbonyl compound 18507
                                      carboxylic ester 15494
                                        lactone 9711
                                          gamma-lactone 6490
                                            butenolide 5911
                                              rofecoxib 111
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