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ONTOLOGY REPORT - ANNOTATIONS


Term:rofecoxib
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Accession:CHEBI:8887 term browser browse the term
Definition:A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke.
Synonyms:exact_synonym: 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
 related_synonym: 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone;   Ceoxx;   Formula=C17H14O4S;   InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3;   InChIKey=RZJQGNCSTQAWON-UHFFFAOYSA-N;   SMILES=CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccccc1;   Vioxx;   rofecoxibum
 xref: Beilstein:8269007;   CAS:162011-90-7;   DrugBank:DB00533;   Drug_Central:2397;   KEGG:C07590;   KEGG:D00568;   LINCS:LSM-2482
 xref_mesh: MESH:C116926
 xref: PMID:10859630;   PMID:11014111;   PMID:12069696;   PMID:16934051;   PMID:20162413;   PMID:28166217;   Reaxys:8269007;   Wikipedia:Rofecoxib


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rofecoxib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adamts8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 JBrowse link 8 32,017,684 32,037,529 RGD:6480464
G Adgrf1 adhesion G protein-coupled receptor F1 JBrowse link 9 20,343,730 20,378,686 RGD:6480464
G Adgrg6 adhesion G protein-coupled receptor G6 JBrowse link 1 8,593,342 8,751,540 RGD:6480464
G Afdn afadin, adherens junction formation factor JBrowse link 1 53,713,873 53,861,918 RGD:6480464
G Alox15b arachidonate 15-lipoxygenase, type B JBrowse link 10 55,773,748 55,783,489 RGD:6480464
G Angpt1 angiopoietin 1 JBrowse link 7 81,338,327 81,592,459 RGD:6480464
G Angptl1 angiopoietin-like 1 JBrowse link 13 74,456,487 74,463,031 RGD:6480464
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:6480464
G Anxa3 annexin A3 JBrowse link 14 14,371,921 14,426,503 RGD:6480464
G Anxa9 annexin A9 JBrowse link 2 196,470,318 196,481,568 RGD:6480464
G Aox1 aldehyde oxidase 1 JBrowse link 9 64,929,682 65,007,872 RGD:6480464
G Arhgap29 Rho GTPase activating protein 29 JBrowse link 2 225,552,075 225,613,349 RGD:6480464
G C2cd4a C2 calcium-dependent domain containing 4A JBrowse link 8 73,671,516 73,686,344 RGD:6480464
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:6480464
G Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 JBrowse link 16 4,871,348 5,795,825 RGD:6480464
G Calca calcitonin-related polypeptide alpha JBrowse link 1 184,184,018 184,188,922 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl20 C-C motif chemokine ligand 20 JBrowse link 9 88,918,359 88,921,017 RGD:6480464
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6480464
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6480464
G Ccn2 cellular communication network factor 2 JBrowse link 1 21,851,657 21,854,773 RGD:6480464
G Cdh2 cadherin 2 JBrowse link 18 8,146,971 8,366,037 RGD:6480464
G Cdh3 cadherin 3 JBrowse link 19 38,668,957 38,719,801 RGD:6480464
G Cdsn corneodesmosin JBrowse link 20 3,704,626 3,707,266 RGD:6480464
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:6480464
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:6480464
G Col14a1 collagen type XIV alpha 1 chain JBrowse link 7 95,054,877 95,274,073 RGD:6480464
G Colec12 collectin sub-family member 12 JBrowse link 18 867,048 1,054,047 RGD:6480464
G Crisp3 cysteine-rich secretory protein 3 JBrowse link 9 24,047,405 24,088,066 RGD:6480464
G Cx3cl1 C-X3-C motif chemokine ligand 1 JBrowse link 19 10,644,267 10,654,861 RGD:6480464
G Cxcl1 C-X-C motif chemokine ligand 1 JBrowse link 14 18,743,678 18,745,457 RGD:6480464
G Cxcl3 C-X-C motif chemokine ligand 3 JBrowse link 14 18,820,168 18,839,659 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Defb4 defensin beta 4 JBrowse link 16 75,634,598 75,637,789 RGD:6480464
G Dsc1 desmocollin 1 JBrowse link 18 11,877,918 11,906,828 RGD:6480464
G Ednrb endothelin receptor type B JBrowse link 15 88,004,775 88,036,354 RGD:6480464
G Epha3 Eph receptor A3 JBrowse link 11 421,253 783,037 RGD:6480464
G Ephb6 Eph receptor B6 JBrowse link 4 70,903,253 70,918,514 RGD:6480464
G Etv5 ETS variant transcription factor 5 JBrowse link 11 82,194,657 82,252,145 RGD:6480464
G Fabp4 fatty acid binding protein 4 JBrowse link 2 93,792,666 93,797,267 RGD:6480464
G Faf1 Fas associated factor 1 JBrowse link 5 129,370,767 129,738,393 RGD:6480464
G Faim2 Fas apoptotic inhibitory molecule 2 JBrowse link 7 141,158,769 141,185,781 RGD:6480464
G Flnb filamin B JBrowse link 15 18,750,152 18,883,019 RGD:6480464
G Foxd1 forkhead box D1 JBrowse link 2 28,460,068 28,462,488 RGD:6480464
G Frzb frizzled-related protein JBrowse link 3 67,635,604 67,668,772 RGD:6480464
G Gata3 GATA binding protein 3 JBrowse link 17 72,419,752 72,452,043 RGD:6480464
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:6480464
G Hpgd 15-hydroxyprostaglandin dehydrogenase JBrowse link 16 37,457,134 37,495,758 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Insm1 INSM transcriptional repressor 1 JBrowse link 3 140,427,961 140,430,467 RGD:6480464
G Itgbl1 integrin subunit beta like 1 JBrowse link 15 110,114,148 110,378,970 RGD:6480464
G Klf12 Kruppel-like factor 12 JBrowse link 15 84,316,986 84,748,549 RGD:6480464
G Lhb luteinizing hormone subunit beta JBrowse link 1 101,409,992 101,413,725 RGD:6480464
G Lifr LIF receptor subunit alpha JBrowse link 2 56,424,910 56,489,346 RGD:6480464
G Lmx1a LIM homeobox transcription factor 1 alpha JBrowse link 13 85,916,753 86,061,534 RGD:6480464
G Mal mal, T-cell differentiation protein JBrowse link 3 120,209,647 120,233,655 RGD:6480464
G Mapre2 microtubule-associated protein, RP/EB family, member 2 JBrowse link 18 14,814,149 15,780,290 RGD:6480464
G Mbtd1 mbt domain containing 1 JBrowse link 10 81,588,233 81,645,532 RGD:6480464
G Mef2c myocyte enhancer factor 2C JBrowse link 2 11,658,534 11,822,788 RGD:6480464
G Meox2 mesenchyme homeobox 2 JBrowse link 6 56,625,768 56,689,195 RGD:6480464
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:6480464
G Mmp3 matrix metallopeptidase 3 JBrowse link 8 5,676,608 5,698,579 RGD:6480464
G Mr1 major histocompatibility complex, class I-related JBrowse link 13 72,771,992 72,789,861 RGD:6480464
G Mta2 metastasis associated 1 family, member 2 JBrowse link 1 225,140,863 225,149,584 RGD:6480464
G Naaladl2 N-acetylated alpha-linked acidic dipeptidase-like 2 JBrowse link 2 109,092,931 110,424,885 RGD:6480464
G Nfasc neurofascin JBrowse link 13 49,335,407 49,522,474 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464
G Nos1 nitric oxide synthase 1 JBrowse link 12 44,214,949 44,405,530 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nox1 NADPH oxidase 1 JBrowse link X 104,909,328 104,932,508 RGD:6480464
G Npas3 neuronal PAS domain protein 3 JBrowse link 6 74,081,995 74,913,025 RGD:6480464
G Npr2 natriuretic peptide receptor 2 JBrowse link 5 59,128,186 59,147,321 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Pi4ka phosphatidylinositol 4-kinase alpha JBrowse link 11 87,858,323 87,975,549 RGD:6480464
G Pla2g2a phospholipase A2 group IIA JBrowse link 5 157,282,650 157,285,295 RGD:6480464
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:6480464
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:6480464
G Pml PML nuclear body scaffold JBrowse link 8 63,002,515 63,034,310 RGD:6480464
G Postn periostin JBrowse link 2 143,656,820 143,688,087 RGD:6480464
G Prrx1 paired related homeobox 1 JBrowse link 13 81,147,038 81,215,559 RGD:6480464
G Ptger3 prostaglandin E receptor 3 JBrowse link 2 263,895,093 263,979,682 RGD:6480464
G Ptgis prostaglandin I2 synthase JBrowse link 3 163,950,746 163,986,129 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rasa1 RAS p21 protein activator 1 JBrowse link 2 13,617,021 13,696,531 RGD:6480464
G Rnf144b ring finger protein 144B JBrowse link 17 17,817,122 17,947,777 RGD:6480464
G Rorc RAR-related orphan receptor C JBrowse link 2 195,612,471 195,636,797 RGD:6480464
G Scd stearoyl-CoA desaturase JBrowse link 1 264,159,966 264,173,061 RGD:6480464
G Serpina3m serine (or cysteine) proteinase inhibitor, clade A, member 3M JBrowse link 6 127,808,785 127,816,067 RGD:6480464
G Sh2d1a SH2 domain containing 1A JBrowse link X 128,897,053 128,925,408 RGD:6480464
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:6480464
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:6480464
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Tac1 tachykinin, precursor 1 JBrowse link 4 33,638,853 33,646,819 RGD:6480464
G Tead4 TEA domain transcription factor 4 JBrowse link 4 161,542,566 161,619,848 RGD:6480464
G Tfrc transferrin receptor JBrowse link 11 71,397,423 71,419,263 RGD:6480464
G Timp3 TIMP metallopeptidase inhibitor 3 JBrowse link 7 23,543,125 23,594,170 RGD:6480464
G Tmprss4 transmembrane serine protease 4 JBrowse link 8 49,469,804 49,503,304 RGD:6480464
G Tnc tenascin C JBrowse link 5 79,789,686 79,874,555 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Trim17 tripartite motif-containing 17 JBrowse link 10 45,307,007 45,314,823 RGD:6480464
G Tspan2 tetraspanin 2 JBrowse link 2 205,160,405 205,202,766 RGD:6480464
G Vcan versican JBrowse link 2 18,490,102 18,587,340 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19758
    role 19705
      biological role 19704
        pharmacological role 18809
          analgesic 13070
            rofecoxib 110
Path 2
Term Annotations click to browse term
  CHEBI ontology 19758
    subatomic particle 19756
      composite particle 19756
        hadron 19756
          baryon 19756
            nucleon 19756
              atomic nucleus 19756
                atom 19756
                  main group element atom 19641
                    p-block element atom 19641
                      carbon group element atom 19532
                        carbon atom 19521
                          organic molecular entity 19521
                            organic group 18428
                              organic divalent group 18419
                                organodiyl group 18419
                                  carbonyl group 18309
                                    carbonyl compound 18309
                                      carboxylic ester 14005
                                        lactone 5894
                                          gamma-lactone 1199
                                            butenolide 339
                                              rofecoxib 110
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.