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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(R)-salsolinol
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Accession:CHEBI:88801 term browser browse the term
Definition:A 1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol that has R-configuration.
Synonyms:exact_synonym: (1R)-1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol
 related_synonym: (+)-Salsolinol;   (R)-1,2,3,4-tetrahydro-1-methyl-6,7-isoquinolinediol;   (R)-1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline;   (R)-SAL;   Formula=C10H13NO2;   InChI=1S/C10H13NO2/c1-6-8-5-10(13)9(12)4-7(8)2-3-11-6/h4-6,11-13H,2-3H2,1H3/t6-/m1/s1;   InChIKey=IBRKLUSXDYATLG-ZCFIWIBFSA-N;   SMILES=C[C@H]1NCCC2=C1C=C(O)C(O)=C2
 xref: CAS:53622-83-6;   HMDB:HMDB0005199
 xref_mesh: MESH:C036617
 xref: PMID:10656535;   PMID:11722700;   PMID:12200189;   PMID:14697894;   PMID:14978525;   PMID:1629715;   PMID:18238832;   PMID:19034892;   PMID:26032572;   PMID:26735443;   PMID:28420969;   PMID:29662355;   PMID:30920734;   PMID:35547657;   PMID:7760044;   PMID:8050034;   PMID:8651468;   PMID:9202326;   PMID:9275315
 cyclic_relationship: is_conjugate_base_of CHEBI:194082;   is_enantiomer_of CHEBI:113


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(R)-salsolinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation EXP salsolinol results in decreased phosphorylation of AKT1 protein CTD PMID:23261589 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP salsolinol results in increased expression of BAX protein CTD PMID:11502874 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP salsolinol results in decreased expression of BCL2 protein CTD PMID:23261589 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP salsolinol results in decreased expression of BCL2L1 protein CTD PMID:11502874 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression EXP salsolinol results in decreased expression of BDNF protein CTD PMID:23261589 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage		 ISO
EXP		 salsolinol results in increased activity of CASP3 protein
Memantine inhibits the reaction [salsolinol results in increased activity of CASP3 protein]
salsolinol results in increased cleavage of CASP3 protein		 CTD PMID:17996985 PMID:23261589 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation EXP salsolinol results in decreased phosphorylation of CREB1 protein CTD PMID:23261589 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO salsolinol results in increased activity of ESR1 protein CTD PMID:24020587 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gdnf glial cell derived neurotrophic factor decreases expression EXP salsolinol results in decreased expression of GDNF protein CTD PMID:23261589 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation EXP salsolinol results in decreased phosphorylation of GSK3B protein CTD PMID:23261589 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO salsolinol results in decreased activity of MAOA protein CTD PMID:2296014 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity EXP salsolinol results in increased activity of MAPK8 protein CTD PMID:11502874 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    chemical entity 19930
      molecular entity 19930
        polyatomic entity 19887
          heteroatomic molecular entity 19841
            hydroxides 19394
              organic hydroxy compound 18991
                isoquinolinol 48
                  1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol 12
                    (R)-salsolinol 12
                      (R)-N-Methylsalsolinol 0
                      salsolinol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            organic molecule 19764
                              organic cyclic compound 19553
                                organic heterocyclic compound 18905
                                  organonitrogen heterocyclic compound 18179
                                    isoquinolines 535
                                      isoquinolinol 48
                                        1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol 12
                                          (R)-salsolinol 12
                                            (R)-N-Methylsalsolinol 0
                                            salsolinol 0
paths to the root