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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:robinetin
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Accession:CHEBI:8876 term browser browse the term
Definition:A pentahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 7, 3, 4' and 5'.
Synonyms:exact_synonym: 3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one
 related_synonym: 5-Deoxymyricetin;   5-Hydroxyfisetin;   Formula=C15H10O7;   InChI=1S/C15H10O7/c16-7-1-2-8-11(5-7)22-15(14(21)12(8)19)6-3-9(17)13(20)10(18)4-6/h1-5,16-18,20-21H;   InChIKey=SOEDEYVDCDYMMH-UHFFFAOYSA-N;   SMILES=Oc1ccc2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O
 xref: AGR:IND500888184;   CAS:490-31-3;   KEGG:C10177;   KNApSAcK:C00001092
 xref_mesh: MESH:C040014
 xref: PMID:16132219;   PMID:19914085;   PMID:25313717;   PMID:25482106;   Reaxys:308905



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robinetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity
multiple interactions
ISO robinetin results in decreased activity of ABCC1 protein
robinetin inhibits the reaction [ABCC1 protein affects the export of fluorexon]
CTD PMID:15670588 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
decreases activity
ISO robinetin inhibits the reaction [ABCC2 protein affects the export of fluorexon]
robinetin results in decreased activity of ABCC2 protein
CTD PMID:15670588 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR gene mutant form inhibits the reaction [robinetin results in increased expression of CYP1A1 mRNA]; AHR gene mutant form inhibits the reaction [robinetin results in increased expression of UGT1A1 mRNA] CTD PMID:29584932 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO AHR gene mutant form inhibits the reaction [robinetin results in increased expression of CYP1A1 mRNA]
robinetin results in increased expression of CYP1A1 mRNA; robinetin results in increased expression of CYP1A1 protein
CTD PMID:29584932 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases expression
ISO AHR gene mutant form inhibits the reaction [robinetin results in increased expression of UGT1A1 mRNA] CTD PMID:29584932 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        biochemical role 19588
          metabolite 19574
            eukaryotic metabolite 19387
              plant metabolite 17985
                robinetin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic molecule 19758
                              organic cyclic compound 19565
                                organic heterocyclic compound 18906
                                  oxacycle 17850
                                    benzopyran 11796
                                      1-benzopyran 11539
                                        flavonoid 6906
                                          anthoxanthin 4541
                                            flavones 4541
                                              hydroxyflavone 4519
                                                flavonols 4410
                                                  7-hydroxyflavonol 4387
                                                    robinetin 5
paths to the root