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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:robinetin
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Accession:CHEBI:8876 term browser browse the term
Definition:A pentahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 7, 3, 4' and 5'.
Synonyms:exact_synonym: 3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one
 related_synonym: 5-Deoxymyricetin;   5-Hydroxyfisetin;   Formula=C15H10O7;   InChI=1S/C15H10O7/c16-7-1-2-8-11(5-7)22-15(14(21)12(8)19)6-3-9(17)13(20)10(18)4-6/h1-5,16-18,20-21H;   InChIKey=SOEDEYVDCDYMMH-UHFFFAOYSA-N;   SMILES=Oc1ccc2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O
 xref: AGR:IND500888184;   CAS:490-31-3;   KEGG:C10177;   KNApSAcK:C00001092
 xref_mesh: MESH:C040014
 xref: PMID:16132219;   PMID:19914085;   PMID:25313717;   PMID:25482106;   Reaxys:308905



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robinetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity
multiple interactions
ISO robinetin results in decreased activity of ABCC1 protein
robinetin inhibits the reaction [ABCC1 protein affects the export of fluorexon]
CTD PMID:15670588 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
decreases activity
ISO robinetin inhibits the reaction [ABCC2 protein affects the export of fluorexon]
robinetin results in decreased activity of ABCC2 protein
CTD PMID:15670588 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR gene mutant form inhibits the reaction [robinetin results in increased expression of CYP1A1 mRNA]; AHR gene mutant form inhibits the reaction [robinetin results in increased expression of UGT1A1 mRNA] CTD PMID:29584932 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO AHR gene mutant form inhibits the reaction [robinetin results in increased expression of CYP1A1 mRNA]
robinetin results in increased expression of CYP1A1 mRNA; robinetin results in increased expression of CYP1A1 protein
CTD PMID:29584932 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases expression
ISO AHR gene mutant form inhibits the reaction [robinetin results in increased expression of UGT1A1 mRNA] CTD PMID:29584932 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        biochemical role 19671
          metabolite 19631
            eukaryotic metabolite 19358
              plant metabolite 17795
                robinetin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  oxacycle 17688
                                    benzopyran 11213
                                      1-benzopyran 10951
                                        flavonoid 6575
                                          flavones 4220
                                            hydroxyflavone 4203
                                              flavonols 4109
                                                7-hydroxyflavonol 4084
                                                  robinetin 5
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