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ONTOLOGY REPORT - ANNOTATIONS


Term:rivastigmine
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Accession:CHEBI:8874 term browser browse the term
Definition:A carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor.
Synonyms:exact_synonym: 3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate
 related_synonym: (S)-3-(1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate;   Formula=C14H22N2O2;   InChI=1S/C14H22N2O2/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4/h7-11H,6H2,1-5H3/t11-/m0/s1;   InChIKey=XSVMFMHYUFZWBK-NSHDSACASA-N;   SMILES=CCN(C)C(=O)Oc1cccc(c1)[C@H](C)N(C)C;   m-((S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
 xref: CAS:123441-03-2 "ChemIDplus";   CAS:123441-03-2 "KEGG COMPOUND";   DrugBank:DB00989;   Drug_Central:2392 "DrugCentral";   KEGG:C11766;   KEGG:D03822;   LINCS:LSM-5280
 xref_mesh: MESH:C072506
 xref: PMID:19032006 "Europe PMC";   PMID:19370562 "Europe PMC";   PMID:19392927 "Europe PMC";   PMID:19619073 "Europe PMC";   PMID:19893314 "Europe PMC";   PMID:20070789 "Europe PMC";   PMID:20370805 "Europe PMC";   PMID:20865460 "Europe PMC";   PMID:21131668 "Europe PMC";   PMID:21246897 "Europe PMC";   PMID:21977379 "Europe PMC";   PMID:21996001 "Europe PMC";   PMID:22009228 "Europe PMC";   PMID:22010358 "Europe PMC";   PMID:22044027 "Europe PMC";   PMID:22054233 "Europe PMC";   PMID:22068922 "Europe PMC";   PMID:22087207 "Europe PMC";   PMID:22163241 "Europe PMC";   PMID:22163242 "Europe PMC";   PMID:22163243 "Europe PMC";   PMID:22173266 "Europe PMC";   PMID:22195801 "Europe PMC";   PMID:22224039 "Europe PMC";   PMID:22230648 "Europe PMC";   PMID:22230878 "Europe PMC";   PMID:22290743 "Europe PMC";   PMID:22362231 "Europe PMC";   PMID:22409834 "Europe PMC";   PMID:22451057 "Europe PMC";   Patent:DE3805744;   Patent:EP1980552;   Patent:EP2233465;   Patent:US2008255383;   Patent:US2009298817;   Patent:US5602176;   Reaxys:7875788 "Reaxys";   Wikipedia:Rivastigmine
 cyclic_relationship: is_conjugate_base_of CHEBI:64363


show annotations for term's descendants       view all columns           Sort by:
 
rivastigmine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:6480464
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:6480464
G Bche butyrylcholinesterase JBrowse link 2 171,104,476 171,196,186 RGD:6480464
G Ces1d carboxylesterase 1D JBrowse link 19 15,195,514 15,239,827 RGD:6480464
G Ces2h carboxylesterase 2H JBrowse link 19 37,052,555 37,067,176 RGD:6480464
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit JBrowse link 3 176,533,182 176,547,965 RGD:6480464
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 2 189,088,570 189,096,785 RGD:6480464
G Hsf1 heat shock transcription factor 1 JBrowse link 7 117,538,523 117,565,478 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      biological role 19596
        pharmacological role 18671
          neurotransmitter agent 16221
            cholinergic drug 4245
              rivastigmine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic group 18331
                              organic divalent group 18321
                                organodiyl group 18321
                                  carbonyl group 18209
                                    carbonyl compound 18209
                                      carboxylic ester 13946
                                        carbamate ester 7330
                                          rivastigmine 10
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