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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rivastigmine
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Accession:CHEBI:8874 term browser browse the term
Definition:A carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor.
Synonyms:exact_synonym: 3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate
 related_synonym: (S)-3-(1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate;   Formula=C14H22N2O2;   InChI=1S/C14H22N2O2/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4/h7-11H,6H2,1-5H3/t11-/m0/s1;   InChIKey=XSVMFMHYUFZWBK-NSHDSACASA-N;   SMILES=CCN(C)C(=O)Oc1cccc(c1)[C@H](C)N(C)C;   m-((S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
 xref: CAS:123441-03-2;   DrugBank:DB00989;   Drug_Central:2392;   KEGG:C11766;   KEGG:D03822;   LINCS:LSM-5280
 xref_mesh: MESH:C072506
 xref: PMID:19032006;   PMID:19370562;   PMID:19392927;   PMID:19619073;   PMID:19893314;   PMID:20070789;   PMID:20370805;   PMID:20865460;   PMID:21131668;   PMID:21246897;   PMID:21977379;   PMID:21996001;   PMID:22009228;   PMID:22010358;   PMID:22044027;   PMID:22054233;   PMID:22068922;   PMID:22087207;   PMID:22163241;   PMID:22163242;   PMID:22163243;   PMID:22173266;   PMID:22195801;   PMID:22224039;   PMID:22230648;   PMID:22230878;   PMID:22290743;   PMID:22362231;   PMID:22409834;   PMID:22451057;   Patent:DE3805744;   Patent:EP1980552;   Patent:EP2233465;   Patent:US2008255383;   Patent:US2009298817;   Patent:US5602176;   Reaxys:7875788;   Wikipedia:Rivastigmine
 cyclic_relationship: is_conjugate_base_of CHEBI:64363


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rivastigmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions EXP Rivastigmine inhibits the reaction [Colchicine results in decreased expression of ACE protein] CTD PMID:17652827 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ache acetylcholinesterase affects activity
decreases activity
multiple interactions
EXP
ISO
Rivastigmine affects the activity of ACHE protein
Rivastigmine results in decreased activity of ACHE protein
AFDX 384 affects the reaction [Rivastigmine affects the activity of ACHE protein]
CTD PMID:12111444 PMID:15135892 PMID:18571635 PMID:19345205 PMID:32092302 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP
ISO
Rivastigmine results in decreased activity of BCHE protein CTD PMID:14535624 PMID:19345205 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Ces1d carboxylesterase 1D decreases activity ISO Rivastigmine results in decreased activity of CES1 protein CTD PMID:23123248 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Rivastigmine results in decreased activity of CES2 protein CTD PMID:23123248 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
affects binding
ISO Rivastigmine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Rivastigmine binds to [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:15733544 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
ISO Rivastigmine binds to [CHRNA4 protein binds to CHRNB2 protein]
Rivastigmine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Rivastigmine results in increased activity of HSF1 protein CTD PMID:19218096 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [Rivastigmine co-treated with donepezil] results in decreased expression of PTGS1 mRNA; [Rivastigmine co-treated with donepezil] results in decreased expression of PTGS1 protein; [Sodium Fluoride co-treated with Rivastigmine co-treated with donepezil] results in increased expression of PTGS1 mRNA; [Sodium Fluoride co-treated with Rivastigmine co-treated with donepezil] results in increased expression of PTGS1 protein; [Sodium Fluoride co-treated with Rivastigmine] results in increased expression of PTGS1 mRNA; [Sodium Fluoride co-treated with Rivastigmine] results in increased expression of PTGS1 protein CTD PMID:29777723 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO [donepezil co-treated with Rivastigmine] results in decreased expression of PTGS2 protein; [Rivastigmine co-treated with donepezil] results in decreased expression of PTGS2 mRNA
Rivastigmine results in decreased expression of PTGS2 mRNA; Rivastigmine results in decreased expression of PTGS2 protein
CTD PMID:29777723 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        pharmacological role 18847
          neurotransmitter agent 16446
            cholinergic drug 4618
              rivastigmine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic ester 14370
                                        carbamate ester 7388
                                          rivastigmine 10
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