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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Riluzole
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Accession:CHEBI:8863 term browser browse the term
Definition:A benzothiazole that has formula C8H5F3N2OS.
Synonyms:related_synonym: 6-Trifluoromethoxybenzothiazol-2-ylamine;   Formula=C8H5F3N2OS;   InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13);   InChIKey=FTALBRSUTCGOEG-UHFFFAOYSA-N;   RP-54274;   RP54274;   SMILES=Nc1nc2ccc(OC(F)(F)F)cc2s1;   rilutek;   rilutor;   riluzole HCl;   riluzole hydrochloride
 xref: CAS:1744-22-5;   Drug_Central:2382;   HMDB:HMDB0014878;   KEGG:C07937;   KEGG:D00775;   LINCS:LSM-2471
 xref_mesh: MESH:D019782


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Riluzole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein alternative form]; Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein]; Riluzole promotes the reaction [AR protein binds to SQSTM1 protein]; Riluzole results in increased degradation of and results in decreased expression of AR protein; Riluzole results in increased degradation of and results in decreased expression of AR protein alternative form; Riluzole results in increased degradation of and results in decreased expression of AR protein mutant form; STF 083010 inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein] CTD PMID:30280407 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Riluzole results in increased expression of ATF6 protein CTD PMID:30280407 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Riluzole results in increased expression of BCL2 protein CTD PMID:20885006 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Riluzole results in increased activity of CASP3 protein] CTD PMID:19528481 PMID:22700542 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 increases activity ISO Riluzole results in increased activity of CASP4 protein CTD PMID:19528481 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Riluzole results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases activity ISO Riluzole results in increased activity of CASP8 protein CTD PMID:19528481 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO Riluzole results in increased activity of CASP9 protein CTD PMID:19528481 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Glul glutamate-ammonia ligase multiple interactions EXP Riluzole inhibits the reaction [manganese chloride results in decreased expression of and results in decreased activity of GLUL protein]; Riluzole inhibits the reaction [manganese chloride results in decreased expression of GLUL mRNA] CTD PMID:19615351 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Riluzole results in increased expression of HSPA5 protein CTD PMID:30280407 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Riluzole CTD PMID:19362101 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Riluzole CTD PMID:19362101 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation EXP Riluzole results in decreased phosphorylation of JUN protein CTD PMID:10067977 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Nefh neurofilament heavy decreases phosphorylation EXP Riluzole results in decreased phosphorylation of NEFH protein CTD PMID:19429076 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nefm neurofilament medium affects localization
decreases phosphorylation
EXP Riluzole affects the localization of NEFM protein
Riluzole results in decreased phosphorylation of NEFM protein
CTD PMID:19429076 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Riluzole results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO Riluzole inhibits the reaction [VEGFA protein results in increased phosphorylation of PRKCB protein] CTD PMID:16303979 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Slc17a7 solute carrier family 17 member 7 decreases expression EXP Riluzole results in decreased expression of SLC17A7 protein CTD PMID:17507170 NCBI chr 1:101,161,265...101,172,292
Ensembl chr 1:101,161,252...101,173,174
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions
increases expression
EXP Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 mRNA]; Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of and results in decreased activity of SLC1A2 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A2 mRNA]
Riluzole results in increased expression of SLC1A2 mRNA; Riluzole results in increased expression of SLC1A2 protein
CTD PMID:19615351 PMID:22966415 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc1a3 solute carrier family 1 member 3 multiple interactions
increases expression
EXP Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 mRNA]; Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of and results in decreased activity of SLC1A3 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A3 mRNA]
Riluzole results in increased expression of SLC1A3 mRNA; Riluzole results in increased expression of SLC1A3 protein
CTD PMID:19615351 PMID:22966415 NCBI chr 2:57,860,881...57,935,363
Ensembl chr 2:57,860,834...57,935,363
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Riluzole promotes the reaction [AR protein binds to SQSTM1 protein] CTD PMID:30280407 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tmprss2 transmembrane serine protease 2 decreases expression ISO Riluzole results in decreased expression of TMPRSS2 mRNA CTD PMID:30280407 NCBI chr11:38,063,914...38,103,406
Ensembl chr11:38,063,915...38,103,290
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Riluzole CTD PMID:19362101 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Utrn utrophin increases expression ISO Riluzole results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,451,809...6,970,040
Ensembl chr 1:6,451,810...6,970,040
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Riluzole inhibits the reaction [VEGFA protein results in increased phosphorylation of PRKCB protein] CTD PMID:16303979 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Riluzole results in increased expression of XBP1 protein CTD PMID:30280407 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link

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  CHEBI ontology 19840
    chemical entity 19840
      atom 19838
        nonmetal atom 19718
          nitrogen atom 18612
            nitrogen molecular entity 18612
              organonitrogen compound 18385
                organonitrogen heterocyclic compound 17555
                  benzothiazoles 140
                    Riluzole 26
Path 2
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  CHEBI ontology 19840
    subatomic particle 19838
      composite particle 19838
        hadron 19838
          baryon 19838
            nucleon 19838
              atomic nucleus 19838
                atom 19838
                  main group element atom 19730
                    p-block element atom 19730
                      carbon group element atom 19635
                        carbon atom 19624
                          organic molecular entity 19624
                            organic molecule 19555
                              organic cyclic compound 19364
                                organic heterocyclic compound 18482
                                  organic heteropolycyclic compound 17872
                                    organic heterobicyclic compound 16804
                                      benzothiazoles 140
                                        Riluzole 26
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