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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(9E,11E)-octadecadienoic acid
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Accession:CHEBI:88464 term browser browse the term
Definition:An octadeca-9,11-dienoic acid having 9-trans,11-trans-stereochemistry.
Synonyms:exact_synonym: (9E,11E)-octadeca-9,11-dienoic acid
 related_synonym: (9E,11E)-9,11-octadecadienoic acid;   (E,E)-9,11-octadecadienoic acid;   (E,E)-isolinoleic acid;   9-trans, 11-trans-CLA;   9-trans,11-trans-conjugated linoleic acid;   9E,11E-CLA;   9t,11t-CLA;   Formula=C18H32O2;   InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-10H,2-6,11-17H2,1H3,(H,19,20)/b8-7+,10-9+;   InChIKey=JBYXPOFIGCOSSB-XBLVEGMJSA-N;   Mangold's acid;   SMILES=OC(=O)CCCCCCC\\C=C\\C=C\\CCCCCC;   conjugated (9E,11E)-linoleic acid;   isolinoleic acid;   trans,trans-9,11-octadecadienoic acid
 xref: AGR:IND44166303;   CAS:544-71-8;   FooDB:FDB023609;   HMDB:HMDB0005047;   LIPID_MAPS_instance:LMFA01030119
 xref_mesh: MESH:C046938
 xref: PMID:11229917;   PMID:12619692;   PMID:16459922;   PMID:16477173;   PMID:17053429;   PMID:17217167;   PMID:17554969;   PMID:19443195;   PMID:19656856;   PMID:20016738;   PMID:2975566
 cyclic_relationship: is_conjugate_acid_of CHEBI:194440

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(9E,11E)-octadecadienoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd36 CD36 molecule increases expression ISO 9,11-linoleic acid results in increased expression of CD36 mRNA CTD PMID:18155510 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Foxo1 forkhead box O1 affects localization ISO 9,11-linoleic acid affects the localization of FOXO1 protein CTD PMID:15992797 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects binding ISO 9,11-linoleic acid binds to PPARA protein CTD PMID:23843199 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects binding ISO 9,11-linoleic acid binds to PPARB protein CTD PMID:23843199 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding
increases activity
ISO 9,11-linoleic acid binds to PPARG protein
9,11-linoleic acid results in increased activity of PPARG protein
CTD PMID:18155510 PMID:23843199 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO 9,11-linoleic acid results in increased phosphorylation of and affects the localization of TP53 protein CTD PMID:15992797 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      application 19622
        anti-inflammatory agent 16505
          (9E,11E)-octadecadienoic acid 6
            (9Z,11E)-9-hydroperoxyoctadeca-9,11-dienoic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      carboxylic acid 18569
                                        monocarboxylic acid 17903
                                          fatty acid 16560
                                            unsaturated fatty acid 978
                                              polyunsaturated fatty acid 717
                                                octadecadienoic acid 168
                                                  conjugated linoleic acid 53
                                                    octadeca-9,11-dienoic acid 30
                                                      (9E,11E)-octadecadienoic acid 6
                                                        (9Z,11E)-9-hydroperoxyoctadeca-9,11-dienoic acid 0
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