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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bryostatin 1
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Accession:CHEBI:88353 term browser browse the term
Definition:A member of the class of bryostatins that is (17E)-2-oxooxacyclohexacos-17-ene which is substituted by hydroxy groups at positions 4, 10, and 20; an acetoxy group at position 8; methyl groups at positions 9, 9, 18, and 19; 2-methoxy-2-oxoethylidene groups at positions 14 and 24; an (E,E)-octa-2,4-dienoyloxy group at position 21; and with oxygen bridges linking positions 6 to 10, 12 to 16, and 20 to 24. It is one of the most abundant member of the class of bryostatins.
Synonyms:exact_synonym: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1(3,7).1(11,15)]nonacos-8-en-12-yl (2E,4E)-octa-2,4-dienoate
 related_synonym: Formula=C47H68O17;   InChI=1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1;   InChIKey=MJQUEDHRCUIRLF-TVIXENOKSA-N;   SMILES=C/1(\\C[C@H]2O[C@@H](C1)C[C@]3(C([C@H](C[C@@H](C[C@H](CC(O[C@@H]([C@@H](C)O)C[C@@]4(C\\C(\\[C@@H]([C@](C(C=C2)(C)C)(O4)O)OC(/C=C/C=C/CCC)=O)=C/C(OC)=O)[H])=O)O)O3)OC(C)=O)(C)C)O)=C\\C(OC)=O
 xref: CAS:83314-01-6;   DrugBank:DB11752;   KEGG:C05149;   KNApSAcK:C00038654
 xref_mesh: MESH:C046785
 xref: PMID:10502742;   PMID:14735696;   PMID:16834754;   PMID:20354984;   PMID:21175177;   PMID:22539107;   PMID:22579485;   PMID:22986161;   PMID:23146662;   PMID:23369356;   PMID:24291721;   PMID:24659806;   PMID:24674872;   PMID:24677503;   PMID:25299527;   PMID:25301233;   PMID:25472878;   PMID:25523423;   PMID:25808573;   PMID:26225566;   PMID:26563568;   PMID:26891037;   PMID:27068183;   PMID:27128726;   PMID:27472877;   PMID:27941949;   PMID:27994072;   PMID:28467486;   PMID:28472666;   PMID:28482641;   PMID:28539614;   PMID:28590053;   PMID:28934369;   PMID:29026042;   PMID:29066536;   PMID:29115558;   PMID:8477194;   PMID:9195893;   PMID:9225066;   Reaxys:4349157;   Wikipedia:Bryostatin


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bryostatin 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO bryostatin 1 results in increased expression of BIRC3 mRNA CTD PMID:14527959 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Cd22 CD22 molecule increases expression ISO bryostatin 1 results in increased expression of CD22 protein CTD PMID:10741703 NCBI chr 1:86,116,376...86,132,782
Ensembl chr 1:86,117,459...86,132,322
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO bryostatin 1 inhibits the reaction [Paclitaxel results in increased activity of CDK1 protein] CTD PMID:10516758 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO bryostatin 1 results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Il10 interleukin 10 decreases expression ISO bryostatin 1 analog results in decreased expression of IL10 mRNA; bryostatin 1 results in decreased expression of IL10 mRNA CTD PMID:15614042 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B decreases expression
increases expression
ISO bryostatin 1 analog results in decreased expression of IL12B mRNA
bryostatin 1 results in increased expression of IL12B mRNA
CTD PMID:15614042 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Itgax integrin subunit alpha X increases expression ISO bryostatin 1 results in increased expression of ITGAX protein CTD PMID:10741703 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
decreases expression
ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCA protein
bryostatin 1 results in decreased expression of PRKCA protein
CTD PMID:8892972 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcb protein kinase C, beta multiple interactions
decreases expression
ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein; [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein alternative form
bryostatin 1 results in decreased expression of PRKCB protein; bryostatin 1 results in decreased expression of PRKCB protein alternative form
CTD PMID:8892972 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions
decreases expression
ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCG protein
bryostatin 1 results in decreased expression of PRKCG protein
CTD PMID:8892972 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link

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  CHEBI ontology 19812
    role 19761
      application 19471
        fuel 11017
          methanol 3858
            methyl ester 3830
              bryostatin 1 10
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic ester 15889
                                        lactone 11245
                                          macrocyclic lactone 5532
                                            macrolide 5480
                                              bryostatins 10
                                                bryostatin 1 10
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