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ONTOLOGY REPORT - ANNOTATIONS


Term:bryostatin 1
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Accession:CHEBI:88353 term browser browse the term
Definition:A member of the class of bryostatins that is (17E)-2-oxooxacyclohexacos-17-ene which is substituted by hydroxy groups at positions 4, 10, and 20; an acetoxy group at position 8; methyl groups at positions 9, 9, 18, and 19; 2-methoxy-2-oxoethylidene groups at positions 14 and 24; an (E,E)-octa-2,4-dienoyloxy group at position 21; and with oxygen bridges linking positions 6 to 10, 12 to 16, and 20 to 24. It is one of the most abundant member of the class of bryostatins.
Synonyms:exact_synonym: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1(3,7).1(11,15)]nonacos-8-en-12-yl (2E,4E)-octa-2,4-dienoate
 related_synonym: Formula=C47H68O17;   InChI=1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1;   InChIKey=MJQUEDHRCUIRLF-TVIXENOKSA-N;   SMILES=C/1(\\C[C@H]2O[C@@H](C1)C[C@]3(C([C@H](C[C@@H](C[C@H](CC(O[C@@H]([C@@H](C)O)C[C@@]4(C\\C(\\[C@@H]([C@](C(C=C2)(C)C)(O4)O)OC(/C=C/C=C/CCC)=O)=C/C(OC)=O)[H])=O)O)O3)OC(C)=O)(C)C)O)=C\\C(OC)=O
 xref: CAS:83314-01-6 "ChemIDplus";   CAS:83314-01-6 "KEGG COMPOUND";   DrugBank:DB11752;   KEGG:C05149;   KNApSAcK:C00038654
 xref_mesh: MESH:C046785
 xref: PMID:10502742 "Europe PMC";   PMID:14735696 "Europe PMC";   PMID:16834754 "Europe PMC";   PMID:20354984 "Europe PMC";   PMID:21175177 "Europe PMC";   PMID:22539107 "Europe PMC";   PMID:22579485 "Europe PMC";   PMID:22986161 "Europe PMC";   PMID:23146662 "Europe PMC";   PMID:23369356 "Europe PMC";   PMID:24291721 "Europe PMC";   PMID:24659806 "Europe PMC";   PMID:24674872 "Europe PMC";   PMID:24677503 "Europe PMC";   PMID:25299527 "Europe PMC";   PMID:25301233 "Europe PMC";   PMID:25472878 "Europe PMC";   PMID:25523423 "Europe PMC";   PMID:25808573 "Europe PMC";   PMID:26225566 "Europe PMC";   PMID:26563568 "Europe PMC";   PMID:26891037 "Europe PMC";   PMID:27068183 "Europe PMC";   PMID:27128726 "Europe PMC";   PMID:27472877 "Europe PMC";   PMID:27941949 "Europe PMC";   PMID:27994072 "Europe PMC";   PMID:28467486 "Europe PMC";   PMID:28472666 "Europe PMC";   PMID:28482641 "Europe PMC";   PMID:28539614 "Europe PMC";   PMID:28590053 "Europe PMC";   PMID:28934369 "Europe PMC";   PMID:29026042 "Europe PMC";   PMID:29066536 "Europe PMC";   PMID:29115558 "Europe PMC";   PMID:8477194 "Europe PMC";   PMID:9195893 "Europe PMC";   PMID:9225066 "Europe PMC";   Reaxys:4349157 "Reaxys";   Wikipedia:Bryostatin


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bryostatin 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:6480464
G Cd22 CD22 molecule JBrowse link 1 89,313,475 89,329,902 RGD:6480464
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6480464
G Itgax integrin subunit alpha X JBrowse link 1 199,555,560 199,576,948 RGD:6480464
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6480464
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6480464
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        fuel 10302
          methanol 2945
            methyl ester 2937
              bryostatin 1 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic ester 13934
                                        lactone 5859
                                          macrocyclic lactone 1515
                                            macrolide 1454
                                              bryostatins 10
                                                bryostatin 1 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.