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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrrolotriazine
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Accession:CHEBI:88341 term browser browse the term
Definition:Any organic heterobicyclic compound containing ortho-fused pyrrolidine and triazine rings.
Synonyms:related_synonym: pyrrolotriazines


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BMS-754807 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO BMS 754807 results in decreased phosphorylation of AKT1 protein
BMS 754807 inhibits the reaction [palbociclib results in increased phosphorylation of AKT1 protein]
CTD PMID:24986516 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases response to substance
ISO [BMS 754807 co-treated with palbociclib] results in increased expression of CCND1 protein; [CCND1 mutant form results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein CTD PMID:24986516 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO [[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; [CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807 CTD PMID:24986516 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO [[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; [CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807 CTD PMID:24986516 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases response to substance ISO CDKN2A gene mutant form results in decreased susceptibility to BMS 754807 CTD PMID:24986516 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
decreases phosphorylation
ISO [BMS 754807 co-treated with palbociclib] results in decreased phosphorylation of IGF1R protein
BMS 754807 results in decreased phosphorylation of IGF1R protein
CTD PMID:24986516 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases response to substance
decreases phosphorylation
ISO BMS 754807 promotes the reaction [palbociclib results in decreased phosphorylation of RB1 protein]
RB1 mutant form results in decreased susceptibility to BMS 754807
BMS 754807 results in decreased phosphorylation of RB1 protein
CTD PMID:24986516 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions
ISO BMS 754807 results in decreased phosphorylation of RPS6KB1 protein
[[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; [CCND1 mutant form results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; palbociclib promotes the reaction [BMS 754807 results in decreased phosphorylation of RPS6KB1 protein]
CTD PMID:24986516 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
remdesivir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Remdesivir decreases expression of CCL2 mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells RGD PMID:32360580 RGD:30309211 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression ISO Remdesivir decreases expression of CXCL10 mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells RGD PMID:32360580 RGD:30309211 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Remdesivir decreases expression of IL1B mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells RGD PMID:32360580 RGD:30309211 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression ISO Remdesivir decreases expression of IL-6 mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells RGD PMID:32360580 RGD:30309211 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Remdesivir decreases expression of TNF mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells RGD PMID:32360580 RGD:30309211 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19791
    chemical entity 19791
      atom 19788
        nonmetal atom 19663
          nitrogen atom 18540
            nitrogen molecular entity 18540
              organonitrogen compound 18310
                organonitrogen heterocyclic compound 17461
                  pyrrolotriazine 13
                    4-\{[5-(methoxycarbamoyl)-2-methylphenyl]amino\}-5-methyl-N-[(1S)-1-phenylethyl]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide 0
                    BMS-754807 8
                    GS-441524 + 5
                    GS-441524 monophosphate 0
                    GS-443902 0
                    N-(3-AMINOPROPYL)-N-[(R)-(3-BENZYL-5-CHLORO-4-OXO-3,4-DIHYDROPYRROLO[2,1-F][1,2,4]TRIAZIN-2-YL)(CYCLOPROPYL)METHYL]-4-METHYLBENZAMIDE 0
                    N-ethyl-4-\{[5-(methoxycarbamoyl)-2-methylphenyl]amino\}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide 0
                    remdesivir 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19791
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19676
                    p-block element atom 19676
                      p-block molecular entity 19676
                        carbon group molecular entity 19579
                          organic molecular entity 19568
                            organic molecule 19493
                              organic cyclic compound 19288
                                organic heterocyclic compound 18407
                                  organic heteropolycyclic compound 17819
                                    organic heterobicyclic compound 16741
                                      pyrrolotriazine 13
                                        4-\{[5-(methoxycarbamoyl)-2-methylphenyl]amino\}-5-methyl-N-[(1S)-1-phenylethyl]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide 0
                                        BMS-754807 8
                                        GS-441524 + 5
                                        GS-441524 monophosphate 0
                                        GS-443902 0
                                        N-(3-AMINOPROPYL)-N-[(R)-(3-BENZYL-5-CHLORO-4-OXO-3,4-DIHYDROPYRROLO[2,1-F][1,2,4]TRIAZIN-2-YL)(CYCLOPROPYL)METHYL]-4-METHYLBENZAMIDE 0
                                        N-ethyl-4-\{[5-(methoxycarbamoyl)-2-methylphenyl]amino\}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide 0
                                        remdesivir 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.