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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:BMS-754807
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Accession:CHEBI:88339 term browser browse the term
Definition:A pyrrolotriazine that is pyrrolo[2,1-f][1,2,4]triazine which is substituted at position 2 by the pyrrolidine nitrogen of (2S)-N-(6-fluoropyridin-3-yl)-2-methylprolinamide, and at position 4 by a (5-cyclopropyl-1H-pyrazol-3-yl)amino group. It is a potent, reversible inhibitor of the insulin-like growth factor 1 receptor/insulin receptor family kinases.
Synonyms:exact_synonym: 1-{4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-N-(6-fluoropyridin-3-yl)-2-methyl-L-prolinamide
 related_synonym: Formula=C23H24FN9O;   InChI=1S/C23H24FN9O/c1-23(21(34)26-15-7-8-18(24)25-13-15)9-3-10-32(23)22-28-20(17-4-2-11-33(17)31-22)27-19-12-16(29-30-19)14-5-6-14/h2,4,7-8,11-14H,3,5-6,9-10H2,1H3,(H,26,34)(H2,27,28,29,30,31)/t23-/m0/s1;   InChIKey=LQVXSNNAFNGRAH-QHCPKHFHSA-N;   SMILES=N1([C@@](CCC1)(C(=O)NC2=CN=C(C=C2)F)C)C3=NN4C(C(=N3)NC5=NNC(=C5)C6CC6)=CC=C4
 xref: LINCS:LSM-6218
 xref_mesh: MESH:C545990
 xref: PDBeChem:EBI;   PMID:19996272;   PMID:20807811;   PMID:23047891;   PMID:25527633;   PMID:25748921


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BMS-754807 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO BMS 754807 results in decreased phosphorylation of AKT1 protein
BMS 754807 inhibits the reaction [palbociclib results in increased phosphorylation of AKT1 protein]		 CTD PMID:24986516 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases response to substance		 ISO [BMS 754807 co-treated with palbociclib] results in increased expression of CCND1 protein; [CCND1 mutant form results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein CTD PMID:24986516 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO [[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; [CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807 CTD PMID:24986516 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO [[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; [CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807 CTD PMID:24986516 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases response to substance ISO CDKN2A gene mutant form results in decreased susceptibility to BMS 754807 CTD PMID:24986516 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
decreases phosphorylation		 ISO [BMS 754807 co-treated with palbociclib] results in decreased phosphorylation of IGF1R protein
BMS 754807 results in decreased phosphorylation of IGF1R protein		 CTD PMID:24986516 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases phosphorylation
decreases response to substance		 ISO BMS 754807 promotes the reaction [palbociclib results in decreased phosphorylation of RB1 protein]
BMS 754807 results in decreased phosphorylation of RB1 protein
RB1 mutant form results in decreased susceptibility to BMS 754807		 CTD PMID:24986516 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions		 ISO BMS 754807 results in decreased phosphorylation of RPS6KB1 protein
[[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; [CCND1 mutant form results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; palbociclib promotes the reaction [BMS 754807 results in decreased phosphorylation of RPS6KB1 protein]		 CTD PMID:24986516 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      application 19741
        pharmaceutical 19579
          drug 19579
            antineoplastic agent 17820
              BMS-754807 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            organic molecule 19764
                              organic cyclic compound 19553
                                organic heterocyclic compound 18905
                                  heteroarene 17172
                                    monocyclic heteroarene 14997
                                      azole 14521
                                        diazole 10779
                                          pyrazoles 2329
                                            BMS-754807 8
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