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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:BMS-754807
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Accession:CHEBI:88339 term browser browse the term
Definition:A pyrrolotriazine that is pyrrolo[2,1-f][1,2,4]triazine which is substituted at position 2 by the pyrrolidine nitrogen of (2S)-N-(6-fluoropyridin-3-yl)-2-methylprolinamide, and at position 4 by a (5-cyclopropyl-1H-pyrazol-3-yl)amino group. It is a potent, reversible inhibitor of the insulin-like growth factor 1 receptor/insulin receptor family kinases.
Synonyms:exact_synonym: 1-{4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-N-(6-fluoropyridin-3-yl)-2-methyl-L-prolinamide
 related_synonym: Formula=C23H24FN9O;   InChI=1S/C23H24FN9O/c1-23(21(34)26-15-7-8-18(24)25-13-15)9-3-10-32(23)22-28-20(17-4-2-11-33(17)31-22)27-19-12-16(29-30-19)14-5-6-14/h2,4,7-8,11-14H,3,5-6,9-10H2,1H3,(H,26,34)(H2,27,28,29,30,31)/t23-/m0/s1;   InChIKey=LQVXSNNAFNGRAH-QHCPKHFHSA-N;   SMILES=N1([C@@](CCC1)(C(=O)NC2=CN=C(C=C2)F)C)C3=NN4C(C(=N3)NC5=NNC(=C5)C6CC6)=CC=C4
 xref: LINCS:LSM-6218
 xref_mesh: MESH:C545990
 xref: PDBeChem:EBI;   PMID:19996272;   PMID:20807811;   PMID:23047891;   PMID:25527633;   PMID:25748921



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BMS-754807 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO BMS 754807 results in decreased phosphorylation of AKT1 protein
BMS 754807 inhibits the reaction [palbociclib results in increased phosphorylation of AKT1 protein]
CTD PMID:24986516 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases response to substance
ISO [BMS 754807 co-treated with palbociclib] results in increased expression of CCND1 protein; [CCND1 mutant form results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein CTD PMID:24986516 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO [[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; [CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807 CTD PMID:24986516 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO [[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; [CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807 CTD PMID:24986516 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases response to substance ISO CDKN2A gene mutant form results in decreased susceptibility to BMS 754807 CTD PMID:24986516 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
decreases phosphorylation
ISO [BMS 754807 co-treated with palbociclib] results in decreased phosphorylation of IGF1R protein
BMS 754807 results in decreased phosphorylation of IGF1R protein
CTD PMID:24986516 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases phosphorylation
decreases response to substance
ISO BMS 754807 promotes the reaction [palbociclib results in decreased phosphorylation of RB1 protein]
BMS 754807 results in decreased phosphorylation of RB1 protein
RB1 mutant form results in decreased susceptibility to BMS 754807
CTD PMID:24986516 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions
ISO BMS 754807 results in decreased phosphorylation of RPS6KB1 protein
[[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; [CCND1 mutant form results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; palbociclib promotes the reaction [BMS 754807 results in decreased phosphorylation of RPS6KB1 protein]
CTD PMID:24986516 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link

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  CHEBI ontology 19918
    role 19894
      application 19729
        pharmaceutical 19565
          drug 19565
            antineoplastic agent 17770
              BMS-754807 8
Path 2
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  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic molecule 19758
                              organic cyclic compound 19565
                                organic heterocyclic compound 18906
                                  heteroarene 17172
                                    monocyclic heteroarene 14893
                                      azole 14396
                                        diazole 10488
                                          pyrazoles 2320
                                            BMS-754807 8
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