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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:BMS-754807
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Accession:CHEBI:88339 term browser browse the term
Definition:A pyrrolotriazine that is pyrrolo[2,1-f][1,2,4]triazine which is substituted at position 2 by the pyrrolidine nitrogen of (2S)-N-(6-fluoropyridin-3-yl)-2-methylprolinamide, and at position 4 by a (5-cyclopropyl-1H-pyrazol-3-yl)amino group. It is a potent, reversible inhibitor of the insulin-like growth factor 1 receptor/insulin receptor family kinases.
Synonyms:exact_synonym: 1-{4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-N-(6-fluoropyridin-3-yl)-2-methyl-L-prolinamide
 related_synonym: Formula=C23H24FN9O;   InChI=1S/C23H24FN9O/c1-23(21(34)26-15-7-8-18(24)25-13-15)9-3-10-32(23)22-28-20(17-4-2-11-33(17)31-22)27-19-12-16(29-30-19)14-5-6-14/h2,4,7-8,11-14H,3,5-6,9-10H2,1H3,(H,26,34)(H2,27,28,29,30,31)/t23-/m0/s1;   InChIKey=LQVXSNNAFNGRAH-QHCPKHFHSA-N;   SMILES=N1([C@@](CCC1)(C(=O)NC2=CN=C(C=C2)F)C)C3=NN4C(C(=N3)NC5=NNC(=C5)C6CC6)=CC=C4
 xref: LINCS:LSM-6218
 xref_mesh: MESH:C545990
 xref: PDBeChem:EBI;   PMID:19996272;   PMID:20807811;   PMID:23047891;   PMID:25527633;   PMID:25748921



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BMS-754807 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO BMS 754807 results in decreased phosphorylation of AKT1 protein
BMS 754807 inhibits the reaction [palbociclib results in increased phosphorylation of AKT1 protein]
CTD PMID:24986516 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases response to substance
ISO [BMS 754807 co-treated with palbociclib] results in increased expression of CCND1 protein; [CCND1 mutant form results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein CTD PMID:24986516 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO [[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; [CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807 CTD PMID:24986516 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO [[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; [CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807 CTD PMID:24986516 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases response to substance ISO CDKN2A gene mutant form results in decreased susceptibility to BMS 754807 CTD PMID:24986516 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
decreases phosphorylation
ISO [BMS 754807 co-treated with palbociclib] results in decreased phosphorylation of IGF1R protein
BMS 754807 results in decreased phosphorylation of IGF1R protein
CTD PMID:24986516 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases response to substance
decreases phosphorylation
ISO BMS 754807 promotes the reaction [palbociclib results in decreased phosphorylation of RB1 protein]
RB1 mutant form results in decreased susceptibility to BMS 754807
BMS 754807 results in decreased phosphorylation of RB1 protein
CTD PMID:24986516 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions
ISO BMS 754807 results in decreased phosphorylation of RPS6KB1 protein
[[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; [CCND1 mutant form results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein; palbociclib promotes the reaction [BMS 754807 results in decreased phosphorylation of RPS6KB1 protein]
CTD PMID:24986516 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link

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  CHEBI ontology 20089
    role 20042
      application 19781
        pharmaceutical 19624
          drug 19655
            antineoplastic agent 17669
              BMS-754807 8
Path 2
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  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  heteroarene 16628
                                    monocyclic heteroarene 13606
                                      azole 12836
                                        diazole 8631
                                          pyrazoles 2308
                                            BMS-754807 8
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