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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:azaperone
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Accession:CHEBI:88301 term browser browse the term
Definition:An N-arylpiperazine that is 2-(piperazin-1-yl)pyridine in which the amino hydrogen is replaced by a 3-(4-fluobenzoyl)propyl group. Used mainly as a tranquiliser for pigs and elephants.
Synonyms:exact_synonym: 1-(4-fluorophenyl)-4-[4-(pyridin-2-yl)piperazin-1-yl]butan-1-one
 related_synonym: 1-(3-(4-Fluorobenzoyl)propyl)-4-(2-pyridyl)piperazine;   1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone;   4'-Fluoro-4-(4-(2-pyridyl)-1-piperazinyl)butyrophenone;   Azaperon;   Formula=C19H22FN3O;   InChI=1S/C19H22FN3O/c20-17-8-6-16(7-9-17)18(24)4-3-11-22-12-14-23(15-13-22)19-5-1-2-10-21-19/h1-2,5-10H,3-4,11-15H2;   InChIKey=XTKDAFGWCDAMPY-UHFFFAOYSA-N;   NSC 170976;   SMILES=C1=C(C=CC(=C1)C(CCCN2CCN(CC2)C3=CC=CC=N3)=O)F;   Stresnil;   azaperona;   azaperonum
 xref: CAS:1649-18-9;   KEGG:D02620;   LINCS:LSM-3012
 xref_mesh: MESH:D001376
 xref: PMID:10982132;   PMID:12398308;   PMID:17186408;   PMID:17386737;   PMID:17929705;   PMID:17939346;   PMID:18689666;   PMID:18817017;   PMID:19111512;   PMID:19395755;   PMID:19395756;   PMID:19579764;   PMID:20006891;   PMID:21210371;   PMID:22287670;   PMID:23140663;   PMID:24490337;   PMID:24712163;   PMID:24807358;   PMID:25105814;   PMID:25655411;   PMID:26056882;   Reaxys:565491;   VSDB:1871;   Wikipedia:Azaperone


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azaperone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Azaperone results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          neurotransmitter agent 16425
            dopaminergic agent 5069
              dopaminergic antagonist 1184
                azaperone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        aromatic amine 13618
                                          aminopyridine 359
                                            azaperone 1
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