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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:9-hydroxyellipticine
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Accession:CHEBI:88297 term browser browse the term
Definition:A organic heterotetracyclic compound that is ellipticine in which the hydrogen at position 9 has been replaced by a hydroxy group.
Synonyms:related_synonym: 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol;   9-OH-E;   9-hydroxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole;   9HE;   Formula=C17H14N2O;   InChI=1S/C17H14N2O/c1-9-14-8-18-6-5-12(14)10(2)17-16(9)13-7-11(20)3-4-15(13)19-17/h3-8,19-20H,1-2H3;   InChIKey=QZTWUDDGLIDXSE-UHFFFAOYSA-N;   SMILES=C1=2C(=C3C(C=NC=C3)=C(C)C2C4=C(N1)C=CC(=C4)O)C
 xref: CAS:51131-85-2;   LINCS:LSM-6642
 xref_mesh: MESH:C008009
 xref: PMID:10737712;   PMID:11724337;   PMID:12083739;   PMID:12570841;   PMID:7049365;   PMID:7265115;   PMID:7448826;   PMID:975074;   PMID:9883907;   Patent:WO9746559;   Reaxys:754367


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9-hydroxyellipticine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 9-hydroxyellipticine; [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 9-hydroxyellipticine; Protons inhibits the reaction [[[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 9-hydroxyellipticine] CTD PMID:22390216 PMID:30914192 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 9-hydroxyellipticine CTD PMID:22390216 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Top2a DNA topoisomerase II alpha affects response to substance ISO TOP2A protein affects the susceptibility to 9-hydroxyellipticine CTD PMID:23293027 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
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  CHEBI ontology 19812
    role 19761
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            antineoplastic agent 17316
              9-hydroxyellipticine 3
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organic heteropolycyclic compound 18059
                                    organic heterotetracyclic compound 9067
                                      9-hydroxyellipticine 3
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