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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:9-hydroxyellipticine
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Accession:CHEBI:88297 term browser browse the term
Definition:A organic heterotetracyclic compound that is ellipticine in which the hydrogen at position 9 has been replaced by a hydroxy group.
Synonyms:related_synonym: 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol;   9-OH-E;   9-hydroxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole;   9HE;   Formula=C17H14N2O;   InChI=1S/C17H14N2O/c1-9-14-8-18-6-5-12(14)10(2)17-16(9)13-7-11(20)3-4-15(13)19-17/h3-8,19-20H,1-2H3;   InChIKey=QZTWUDDGLIDXSE-UHFFFAOYSA-N;   SMILES=C1=2C(=C3C(C=NC=C3)=C(C)C2C4=C(N1)C=CC(=C4)O)C
 xref: CAS:51131-85-2;   LINCS:LSM-6642
 xref_mesh: MESH:C008009
 xref: PMID:10737712;   PMID:11724337;   PMID:12083739;   PMID:12570841;   PMID:7049365;   PMID:7265115;   PMID:7448826;   PMID:975074;   PMID:9883907;   Patent:WO9746559;   Reaxys:754367



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9-hydroxyellipticine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 9-hydroxyellipticine; [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 9-hydroxyellipticine; Protons inhibits the reaction [[[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 9-hydroxyellipticine] CTD PMID:22390216 PMID:30914192 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 9-hydroxyellipticine CTD PMID:22390216 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Top2a DNA topoisomerase II alpha affects response to substance ISO TOP2A protein affects the susceptibility to 9-hydroxyellipticine CTD PMID:23293027 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link

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  CHEBI ontology 20089
    role 20042
      application 19781
        pharmaceutical 19624
          drug 19655
            antineoplastic agent 17669
              9-hydroxyellipticine 3
Path 2
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  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  organic heteropolycyclic compound 18298
                                    organic heterotetracyclic compound 9097
                                      9-hydroxyellipticine 3
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