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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:9-hydroxyellipticine
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Accession:CHEBI:88297 term browser browse the term
Definition:A organic heterotetracyclic compound that is ellipticine in which the hydrogen at position 9 has been replaced by a hydroxy group.
Synonyms:related_synonym: 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol;   9-OH-E;   9-hydroxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole;   9HE;   Formula=C17H14N2O;   InChI=1S/C17H14N2O/c1-9-14-8-18-6-5-12(14)10(2)17-16(9)13-7-11(20)3-4-15(13)19-17/h3-8,19-20H,1-2H3;   InChIKey=QZTWUDDGLIDXSE-UHFFFAOYSA-N;   SMILES=C1=2C(=C3C(C=NC=C3)=C(C)C2C4=C(N1)C=CC(=C4)O)C
 xref: CAS:51131-85-2;   LINCS:LSM-6642
 xref_mesh: MESH:C008009
 xref: PMID:10737712;   PMID:11724337;   PMID:12083739;   PMID:12570841;   PMID:7049365;   PMID:7265115;   PMID:7448826;   PMID:975074;   PMID:9883907;   Patent:WO9746559;   Reaxys:754367


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9-hydroxyellipticine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 9-hydroxyellipticine CTD PMID:22390216 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
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G Top2a DNA topoisomerase II alpha affects response to substance ISO TOP2A protein affects the susceptibility to 9-hydroxyellipticine CTD PMID:23293027 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            antineoplastic agent 16982
              9-hydroxyellipticine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteropolycyclic compound 17820
                                    organic heterotetracyclic compound 4332
                                      9-hydroxyellipticine 2
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