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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:azaribine
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Accession:CHEBI:88272 term browser browse the term
Definition:A N-glycosyl-1,2,4-triazine that is 6-azauridine acetylated at positions 2', 3' and 5' on the sugar ring. It is a prodrug for 6-azauridine and is used for treatment of psoriasis.
Synonyms:exact_synonym: 2-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1,2,4-triazine-3,5(2H,4H)-dione
 related_synonym: 2',3',5'-Tri-O-acetyl-6-azauridine;   2',3',5'-Triacetyl-6-azauridine;   2-(2',3',5'-Triacetyl-beta-D-ribofuranosyl)-as-triazine-3,5-(2H,4H)-dione;   2-beta-D-Ribofuranosyl-as-triazine-3,5(2H,4H)-dione 2',3',5'-triacetate;   6-Azauridine 2',3',5'-triacetate;   Formula=C14H17N3O9;   InChI=1S/C14H17N3O9/c1-6(18)23-5-9-11(24-7(2)19)12(25-8(3)20)13(26-9)17-14(22)16-10(21)4-15-17/h4,9,11-13H,5H2,1-3H3,(H,16,21,22)/t9-,11-,12-,13-/m1/s1;   InChIKey=QQOBRRFOVWGIMD-OJAKKHQRSA-N;   SMILES=N=1N(C(NC(C1)=O)=O)[C@@H]2O[C@@H]([C@H]([C@H]2OC(=O)C)OC(C)=O)COC(C)=O;   Triacetyl-6-azauridine;   Triazure;   azaribina;   azaribinum
 xref: Beilstein:631776;   CAS:2169-64-4;   Drug_Central:27;   KEGG:D03029;   LINCS:LSM-20874
 xref_mesh: MESH:C100231
 xref: PMID:1036874;   PMID:1096923;   PMID:11600283;   PMID:1173747;   PMID:1243822;   PMID:14023746;   PMID:203231;   PMID:324277;   PMID:5137963;   PMID:5171778;   PMID:5911950;   PMID:6198500;   PMID:766762;   PMID:8570536;   Reaxys:631776



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azaribine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Umps uridine monophosphate synthetase increases activity ISO azaribine results in increased activity of UMPS protein CTD PMID:1036874 NCBI chr11:66,806,107...66,816,520
Ensembl chr11:66,806,045...66,821,903
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Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        pro-agent 10115
          prodrug 9918
            azaribine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            heteroorganic entity 19278
                              organochalcogen compound 19052
                                organooxygen compound 18998
                                  carbohydrates and carbohydrate derivatives 12342
                                    carbohydrate 12342
                                      carbohydrate derivative 11946
                                        glycosyl compound 10983
                                          N-glycosyl compound 5520
                                            N-glycosyl-1,2,4-triazine 1
                                              6-azauridine 1
                                                azaribine 1
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